Dinoprost, Trometamolsalz

Dinoprost tromethamine Struktur
38562-01-5
CAS-Nr.
38562-01-5
Bezeichnung:
Dinoprost, Trometamolsalz
Englisch Name:
Dinoprost tromethamine
Synonyma:
583e;u14585;lutalyse;Ensaprost;u-14,583e;PGF2ALPHA;PGF2αTris;Zinoprost;haminesalt;PGF2a-THAM
CBNumber:
CB9394313
Summenformel:
C24H45NO8
Molgewicht:
475.62
MOL-Datei:
38562-01-5.mol

Dinoprost, Trometamolsalz Eigenschaften

Schmelzpunkt:
100-101°
storage temp. 
-20°C
Löslichkeit
H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
Aggregatzustand
powder
Farbe
white
Merck 
13,7970
BRN 
4087514
Stabilität:
Hygroscopic
InChIKey
IYGXEHDCSOYNKY-RZHHZEQLSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 60-22
S-Sätze: 53-45
WGK Germany  3
RTECS-Nr. UK8025000
8-10
HS Code  2937500000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Dinoprost, Trometamolsalz Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.

Chemische Eigenschaften

White Solid

Verwenden

One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.

Indications

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

Definition

dinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.

Sicherheitsprofil

Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also other prostaglandin entries.

Dinoprost, Trometamolsalz Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dinoprost, Trometamolsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 254)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2996 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 990 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 616 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9354 55
Shanghai finete Pharmaceutical Co., Ltd.
+86-18221039705
CHINA 139 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5909 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58

38562-01-5(Dinoprost, Trometamolsalz)Verwandte Suche:


  • 583e
  • 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacid,tromet
  • Tromethamine salt
  • PGF2α (Prostaglandin F2α)
  • Dinoprost TroMethaMine USP
  • Dinorprost tromethamine
  • (E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component of prostin F2 alpha, injectable
  • Dinoprost compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Ensaprost
  • Dinoprost Tromethamine (50 mg)
  • (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid 2-AMino-2-(hydroxyMethyl)-1,3-propanediol
  • 7-[3,5-Dihydroxy-2-(3-hydroxy-1- octenyl)cyclopentyl]-5-heptenoic Acid TroMethaMine
  • 9α,11α,15(S)-Trihydroxy-5-cis-13-trans-prostadienoic Acid TroMethaMine
  • 9α,11α-PGF2 TroMethaMine
  • 9α,11α-PGF2α TroMethaMine
  • thampgf2-alpha
  • tromethamineprostaglandinf2-alpha
  • u-14,583e
  • u14585
  • PROSTAGLANDINS F2ALPHA TRIS SALT
  • PROSTAGLANDIN F2-ALPHA, TRIMETHAMINE SALT
  • PROSTAGLANDIN F2ALPHA TRIS SALT
  • PROSTAGLANDIN F2ALPHA TROMETHAMINE
  • PROSTAGLANDIN F2ALPHA TROMETHAMINE SALT
  • prostaglandin f2a tris salt
  • PGF2ALPHA
  • PGF2ALPHA THAM
  • PGF2ALPHA-TRIS
  • PGF2ALPHA TRIS SALT
  • 9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic acid tris(hydroxymethyl)aminomethane salt
  • 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicacitham
  • compd.withtrimethylolaminomethane
  • haminesalt
  • 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-OIC ACID, TRIS(HYDROXYMETHYL) AMINOMETHANE SALT
  • (5z,9a,11a,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt
  • Tromethamine prostaglandin F2α
  • PGF2a-THAM
  • PGF2α-Tris, Prostaglandin F2α tris salt, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
  • PGF2α-Tris, (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dienoic acid tris salt
  • PGF2αTris
  • lutalyse
  • pgf2-alphatromethamine
  • pgf2-alphatromethaminesalt
  • prostaglandinf2-alphatham
  • prostaglandinf2-alphathamsalt
  • prostaglandinf2atromethamine
  • protaglandinf2-alpha-thamsalt
  • DINOPROST TROMETHAMINE
  • DINOPROST (TROMETHAMINE SALT)
  • dinoprost, trometamol salt
  • prostaglandin F2A tris
  • prostaglandin F2-alpha, trometamol salt
  • PROSTAGLANDIN F2A TRIS GAMMA-IRRADIATED CELL CULTUR
  • PROSTAGLANDIN F2A TRIS CELL*CULTURE TEST ED
  • [5Z,9ALPHA,11ALPHA,13E,15S]-9,11,15-TRIHYDROXYPROSTA-5,13-DIENOIC ACID TRIS SALT
  • Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • (5z,9α,11α,13e,15s)-9,11,15-trihydroxyprosta-5,13-dienoic acid tris salt
  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oate (salt) (9CI)
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