ChemicalBook >> CAS DataBase List >>Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
- CAS No.
- 769195-26-8
- Chemical Name:
- Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
- Synonyms
- RETAG-003;Sitagliptin-10;Sitagliptin Impurity 55;Sitagliptin EP Impurity 17;3-oxo-4-(2,4,5-trifluorophenyl;Methyl 3-oxo-4-(2,4,5-trifluorophenyl);Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester;2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
- CBNumber:
- CB01010402
- Molecular Formula:
- C11H9F3O3
- Molecular Weight:
- 246.19
- MDL Number:
- MFCD09833197
- MOL File:
- 769195-26-8.mol
- MSDS File:
- SDS
Last updated:2024-03-22 17:12:53
Melting point | 40-41 °C |
---|---|
Boiling point | 273.3±35.0 °C(Predicted) |
Density | 1.330±0.06 g/cm3(Predicted) |
refractive index | 1.469 |
Flash point | 115.5±20.8 °C |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9.95±0.46(Predicted) |
color | Pale Yellow to Light Yellow |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311-H315-H319 |
Precautionary statements | P501-P270-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P405 |
HS Code | 2918300090 |
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | M320785 | Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate | 769195-26-8 | 1g | $60 | 2021-12-16 | Buy |
TRC | M320785 | Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate | 769195-26-8 | 5g | $110 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | HCH0037407 | METHYL 3-OXO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOATE 95.00% | 769195-26-8 | 5G | $909.56 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 60177 | Methyl3-Oxo-4-(2,4,5-trifluorophenyl)butanoate | 769195-26-8 | 100g | $950 | 2021-12-16 | Buy |
AK Scientific | Z1749 | Methyl3-oxo-4-(2,4,5-trifluorophenyl)butanoate | 769195-26-8 | 1g | $104 | 2021-12-16 | Buy |
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Uses
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.
Preparation
The preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.
Synthesis of Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate from Potassium 3-methoxy-3-oxopropanoate and 2,4,5-Trifluorophenylacetic acid
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Preparation Products And Raw materials
Global( 155)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xinxiang Hongqi District Houyuan Trading Co.,Ltd | +86-0373-3695376 +86-13937349994 | HYJM@houyuanjm.com | China | 300 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
View Lastest Price from Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-23 | Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-05-31 | 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
769195-26-8
|
US $0.00 / Kg | 1Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd | ||
2023-05-31 | Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
|
US $0.00 / Kg | 1Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd |
- Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
- 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
769195-26-8
- US $0.00 / Kg
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
- Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8
- US $0.00 / Kg
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
769195-26-8(Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate)Related Search:
(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
Sitagliptin phosphate
Sitagliptin Impurity 31
Sitagliptin impurity H HCl
Sitagliptin Impurity 34
1of4
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
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Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester
3-oxo-4-(2,4,5-trifluorophenyl
Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester
Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate
Methyl 3-oxo-4-(2,4,5-trifluorophenyl)
RETAG-003
Sitagliptin Impurity 55
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
Sitagliptin-10
3-oxo-4-(2,4,5-trifluorophenyl)butanoic acid methyl ester
Benzenebutanoic acid, 2,4,5-trifluoro-β-oxo-, methyl ester
Sitagliptin EP Impurity 17
2,4,5-Trifluoro-β-oxo-benzenebutanoic Acid Methyl Ester
ethyl (S)-3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
769195-26-8