4,4'-Cyclohexylidenebisphenol
- CAS No.
- 843-55-0
- Chemical Name:
- 4,4'-Cyclohexylidenebisphenol
- Synonyms
- BISPHENOL Z;1,1-BIS(4-HYDROXYPHENYL)CYCLOHEXANE;4,4'-(Cyclohexane-1,1-diyl)diphenol;1,1-Bis(4-hydroxyphenyl)cyclohexane (Bisphenol Z);Ai3-16834;Ccris 4918;Einecs 212-677-1;ZERENEX ZX005270;Bisphenol Z Solution;Bisphenol Z (100μg/mL)
- CBNumber:
- CB0103479
- Molecular Formula:
- C18H20O2
- Molecular Weight:
- 268.35
- MDL Number:
- MFCD00019341
- MOL File:
- 843-55-0.mol
- MSDS File:
- SDS
| Melting point | 190-192 °C(lit.) |
|---|---|
| Boiling point | 371.51°C (rough estimate) |
| Density | 1.0496 (rough estimate) |
| refractive index | 1.5490 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| Water Solubility | Practically insoluble in water |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 9.91±0.30(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C18H20O2/c19-16-8-4-14(5-9-16)18(12-2-1-3-13-18)15-6-10-17(20)11-7-15/h4-11,19-20H,1-3,12-13H2 |
| InChIKey | SDDLEVPIDBLVHC-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(O)C=C2)(C2=CC=C(O)C=C2)CCCCC1 |
| CAS DataBase Reference | 843-55-0(CAS DataBase Reference) |
| FDA UNII | 64ZF6464QY |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29072990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4,4'-Cyclohexylidenebisphenol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 450421 | 4,4′-Cyclohexylidenebisphenol 98% | 843-55-0 | 25g | $69.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 77923 | BisphenolZ analytical standard | 843-55-0 | 100mg | $55.2 | 2021-12-16 | Buy |
| TCI Chemical | B1568 | 1,1-Bis(4-hydroxyphenyl)cyclohexane >98.0%(GC) | 843-55-0 | 25g | $49 | 2026-04-30 | Buy |
| TCI Chemical | B1568 | 1,1-Bis(4-hydroxyphenyl)cyclohexane >98.0%(GC) | 843-55-0 | 100g | $139 | 2026-04-30 | Buy |
| TRC | TRC-B519650-50G | Bisphenol Z | 843-55-0 | 50g | $303 | 2026-06-03 | Buy |
4,4'-Cyclohexylidenebisphenol Chemical Properties, Uses, Production
Chemical Properties
White Crystal
Uses
Bisphenol Z is one of the many derivatives of Bisphenol A (B519495) that can be used as HIF (hypoxia-inducible factor) inhibitors, antitumor agents, angiogenesis inhibitors, and antihypoxic agents.
Definition
ChEBI: Bisphenol Z is a diarylmethane.
Synthesis
In a 500 mL four-necked flask equipped with a PTFE stirrer, thermometer, reflux condenser and HCl gas introduction tube, 150.4 g (16 mol) of phenol, 39.2 g (0.4 mol) of cyclohexanone, 100 mL of toluene, and 624 g (008 mol) of 2-mercaptoethanol were added; and +dried HCl gas was passed through the flask at a uniform rate of 016 mol/h. The reaction was heated to 30 C and maintained for 7 h. Stopping stirring and heating, the slurry was filtered under pressure to obtain a pink filter cake. The reaction was heated in a water bath, raised to 30 C and kept for 7 h. Stirring and heating were stopped and the resulting slurry-like consistency was filtered under reduced pressure to give a pink filter cake. The filter cake was washed with deionized water at 100 for 3~4 times until the pH was 7, and the crude product was dried to obtain 114.5 g. The crude product was dissolved in a round bottom flask heated with anhydrous ethanol, and then filtered under reduced pressure while it was hot to filter off the impurities insoluble in ethanol, the filtrate was cooled to room temperature, and then put into a refrigerator to cool down for crystallization, and recrystallized for 2~3 times, and the white crystals of 105.5 g were obtained with the yield of 98.4%.
4,4'-Cyclohexylidenebisphenol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Mianyang Vandino Pharmaceutical Technology Co., Ltd. | 15681201579 15861805752 | 1755695756@qq.com | China | 256 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 94607 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| shanghai science Bio-Pharmceutical.co,ltd. | 021-021-57872719 13761402923 | 245662540@qq.com | China | 299 | 60 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 4,4'-Cyclohexylidenebisphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-22 | 4,4'-Cyclohexylidenebisphenol
843-55-0
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | 4,4'-Cyclohexylidenebisphenol
843-55-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-14 | Bisphenol Z
843-55-0
|
$1210.00-2000.00 | 99.88% | 10g | TargetMol Chemicals Inc. |
-
- 4,4'-Cyclohexylidenebisphenol
843-55-0
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4,4'-Cyclohexylidenebisphenol
843-55-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Bisphenol Z
843-55-0
- $1210.00-2000.00
- 99.88%
- TargetMol Chemicals Inc.
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