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Disinfectants Carcinogenicity Toothpaste Standard Chemical Properties Uses Production method

CAS No. 3380-34-5
Chemical Name: Triclosan
Synonyms: ch3565;IRGASAN;TROX-100;TRICLOSAN;Cloxifenol;ZilesanUW.;TRICHLOSAN;Irgacare MP;irgasandp300;Trichlorosan
CBNumber: CB6771432
Molecular Formula: C12H7Cl3O2
Formula Weight: 289.54
MOL File: 3380-34-5.mol
Triclosan Property
Melting point : 56-60 °C(lit.)
storage temp. : Refrigerator
solubility : H2O: soluble12g/L at 20°C
color : colorless or white
Water Solubility : Soluble in ethanol, methanol, diethyl ether and sodium hydroxide solution (1M). Slightly soluble in water.
Merck : 14,9657
BRN : 2057142
Stability:: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference: 3380-34-5(CAS DataBase Reference)
NIST Chemistry Reference: Triclosan(3380-34-5)
EPA Substance Registry System: Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- (3380-34-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xi,N
Risk Statements : 36/38-50/53-36/37/38
Safety Statements : 26-39-46-60-61-24/25-22-36
RIDADR : UN 3077 9/PG 3
WGK Germany : 2
RTECS : KO1100000
TSCA : Yes
HazardClass : 9
PackingGroup : III
Hazardous Substances Data: 3380-34-5(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P321 Specific treatment (see … on this label).
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Triclosan Chemical Properties,Usage,Production

Triclosan is an efficient broad-spectrum topical antimicrobial disinfectant which is normally white or off-white crystalline powder. It has a slightly phenolic odor. It is insoluble in water but easily soluble in organic solvents and alkali. It has a relative stable chemical property and is heating-resistant and also resistant to acid and alkali hydrolysis without generating any symptoms of the toxicity and environmental pollution. It is internationally recognized as a fungicide variety with specific efficacy. It can kill bacteria such as Staphylococcus aureus, Escherichia coli and fungi such as Candida albicans. It also has an inhibitory effect on the virus (e.g., hepatitis B virus, etc.) while being able to protect the beneficial bacteria. The mechanism of action of triclosan is as below: it is first adsorbed on the bacterial cell wall and then further penetrates through the cell wall and has reaction with the lipid and protein in the cytoplasm, and thus resulting in protein denaturation which further kill the bacteria. Currently it has been widely applied to highly-efficient medicated soap (health soap, health lotion), removing underarm odor (foot aerosol), hand sanitizer, wound disinfectant sprays, medical equipment disinfectants, hygiene cleanser (cream), and air fresheners and refrigerator deodorants and some other daily chemicals. It is also used for the cleaning of the health fabric and the anti-corrosion treatment of plastics. Its high purity version can be added to the toothpaste and mouthwash for treatment of gingivitis, periodontitis and oral ulcers. The State content must not exceed 0.3%.
In 2004, a teacher (Dr. Peter Vikesland) from the Virginia Tech University (US) had found from the experiments that the reaction between the triclosan-containing product and the chlorine-containing tap water containing can generate a substance known as "chloroform aryl", that is, chloroform (chemical name: trichloromethane) which is a colorless, volatile liquid with a special sweetness. Upon exposure to light, it will be oxidized to generate hydrogen chloride and phosgene. It had been once used as an anesthetic. Animal experiments have found that this substance will do harm to the heart and liver with mild teratogenicity and can induce the liver cancer of mice. However, so far no studies on the human carcinogenicity have been reported. For insurance purposes, both the International Cancer Research Centre and the United States have already has the chloroform be listed as suspected carcinogens to the human body.
Toothpaste Standard
The national standard of the toothpaste used in China is the new national standard of toothpaste (GB8372-2008) implemented on February 1, 2009. Compared with the 2001 version of toothpaste standard, the new national standard has been supplemented and adjusted in various aspects. In the new national standard of toothpaste, the prohibited or restricted ingredients include nearly 1,500 kinds, including diethylene glycol and triclosan. The provision of diethylene glycol is that it is not allowed to artificially add it to the raw materials, such as being introduced as impurities. Its content in the toothpaste should not exceed 0.1%. Triclosan were listed as being allowable preservatives but with the usage amount not exceeding 0.3%. The new national standard has ruled that the fluorine content of the fluoride-containing toothpaste should be within the range of 0.04%-0.15%, and the fluoride content should be within the range of 0.05% to 011% for children fluoride-containing toothpaste.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Chemical Properties
It is colorless and long needle-like crystals with a melting point being around 54-57.3 ℃ (60-61 ℃). It is slightly soluble in water and soluble in ethanol, acetone, ethyl ether and alkali solution. It has a chloro-phenol odor.
1. It can be used as antiseptic and fungicide and applied to cosmetics, emulsions and resins; also can be used for the manufacture of disinfection medicated soap. The LD50 of mice subject to oral administration of this product is 4g/kg.
2. It can be used for the production of top-grade daily chemical product, the disinfectants of medical instrument as well as diet instrument as well as the preparation of the anti-bacterial, deodorant finishing agent of fabric.
3. It can also be applied to biochemical studies. It is a kind of broad-spectrum antimicrobial agents which inhibit the type II fatty acid synthase (FAS-II) of bacteria and parasites, and also inhibits the mammalian fatty acid synthase (FASN), and may also have anticancer activity
Production method
1. Take 2, 4-dichloro-phenol as the raw material; use 2,4-dichloro-phenol to react with potassium hydroxide to generate dichlorophenol potassium which further reacts with 2,5-dichloro-nitrobenzene in the catalysis of copper for generation of 2,4,4-trichloro-2'-nitro diphenyl ether. It is further reduced by iron powder to generate 2, 4, 4-trichloro-2'-amino diphenyl ether, and then further went through diazotization hydrolysis to obtain the product.
2. Take o-methoxyphenol as the raw material: have potassium hydroxide powder reacted with guaiacol to generate guaiacol potassium. Apply reaction between bromobenzene and methoxy ether, together with chlorine for chlorination to obtain 2, 4, 4’-trichloro-2'-methoxydiphenyl ether. Take AICI3 as hydrolysis catalyst to generate 2,4,4'-trichloro-2'-hydroxydiphenyl ether.
Chemical Properties
Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.
ChEBI: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodo ants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Triclosan Preparation Products And Raw materials
Raw materials
Copper Potassium hydroxide Guaiacol 2,4-Dichlorophenol 2-Phenoxyaniline Diphenyl oxide Bromobenzene 2,6-Dichlorophenol Iron
Preparation Products
Triclosan Suppliers      Global( 302)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 CHINA 3230 55
Jiangsu Equalchem Co., Ltd +86-513-80923038,83887909
+86-513-83887908 China 12 60
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 China 1944 62
Wuhan HongxinKang Fine Chemical Co., Ltd. 027-59362599 18674037007
027-84802889 China 942 58
Hubei ZhengXingyuan Chemical Co., Ltd. 027-87879183 18707110115 027-87877282 18827340804
027-87879183 China 317 58
Tianjin Zhongxin Chemtech Co., Ltd. 86(0)22-89880739
86(0)22-89880739 ext 8030 / 86-22-66880086 China 554 60
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499; China 6041 61
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30314 84
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 China 2364 56
3380-34-5(Triclosan)Related Search:
Perchlorate, ClO{|: glass body: double junction electrode: kit AMMONIUM PERCHLORATE Trichlorosilane Ethylbenzene Dimethyl ether Trichloroisocyanuric acid PETROLEUM ETHER Diphenyl oxide Phenol Dicofol Trichloroethane Phenol Red Chloroform Trichloroethylene Difluorochloromethane 3-Aminophenol 2-Butoxyethanol Diethyl ether
2,4,4-trichloro-2-hydroxydiphenylether(irgasandp-300) 2’-hydroxy-2,4,4’-trichloro-phenylethe 5-chloro-2-(2,4-dichlorophenoxy)-pheno ch3565 Cloxifenol ether,2’-hydroxy-2,4,4’-trichlorodiphenyl irgasandp300 ZilesanUW. IRGASAN Building Blocks Antibiotics A to Z Antibiotics G-M Antibiotics BioChemical 3380-34-5 2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER 2,4,4-TRICHLORO-2-HYDROXYDIPHENYL ETHER TRICLOSAN trichloro-2'-hydroxydiphenylether TROX-100 Oxygen Compounds Phenols Organic Building Blocks TRICHLOSAN TRICLOSAN USP 2,4,4'Trichloro2'-HydroxyDiphenyaxide 2,4,4'-Trichloro-2-2' Hydroxy Diphenyl Ether C12H7Cl3O2 2,4,4'-Trichloro-2'-hydroxydiphenyl ether (Triclosan) Phenol, 5-chloro-2-(2,4-dichlorophenoxy)- TRICLOSAN,99%(BULK TRICHLOROHYDROXYDIPHENYLETHER Intermediates Miscellaneous Organics Biphenyl & Diphenyl ether 2,4,4'-Trichloro-2'-hydroxydiphenyl ether triclosan 2,4,4'-trichloro-2'-hydroxy-diphenyl-ether 5-chloro-2-(2,4-dichlorophenoxy)phenol 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Triclosan Organic Building Blocks Oxygen Compounds Phenols ClC6H3OC6H3Cl2OH (4-Chloro-2-hydroxyphenyl)(2,4-dichlorophenyl) ether 5-Chloro-2-(2,4-dichlorophenoxy)phenol Triclosan (200 mg) Aromatics Intermediates & Fine Chemicals Pharmaceuticals TRICLOSAN (2',4,4'-TRICHLORO-2-HYDROXYDIPHENYL ETHER) Building Blocks C9 to C20+ Chemical Synthesis Organic Building Blocks Oxygen Compounds Irgacare MP TriMetazidine dichlorhydrate 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL F
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