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Butylated Hydroxytoluene

Chemical Properties Mammalian physiology
Butylated Hydroxytoluene
Butylated Hydroxytoluene structure
CAS No.
128-37-0
Chemical Name:
Butylated Hydroxytoluene
Synonyms
p21;BHT;ao4k;ao29;BUKS;SDI1;cao1;cao3;DBMP;P 21
CBNumber:
CB8355755
Molecular Formula:
C15H24O
Formula Weight:
220.35
MOL File:
128-37-0.mol

Butylated Hydroxytoluene Properties

Melting point:
69-73 °C(lit.)
Boiling point:
265 °C(lit.)
Density 
1.048
vapor density 
7.6 (vs air)
vapor pressure 
<0.01 mm Hg ( 20 °C)
FEMA 
2184 | BUTYLATED HYDROXYTOLUENE
refractive index 
1.4859
Flash point:
127 °C
storage temp. 
0-6°C
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Crystals
pka
pKa 14(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
color 
white
Odor
faint characteristic odor
Water Solubility 
insoluble
Merck 
14,1548
BRN 
1911640
Stability:
Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
InChIKey
NLZUEZXRPGMBCV-UHFFFAOYSA-N
CAS DataBase Reference
128-37-0(CAS DataBase Reference)
EWG's Food Scores
4
FDA UNII
1P9D0Z171K
NIST Chemistry Reference
Butylated hydroxytoluene(128-37-0)
EPA Substance Registry System
2,6-Di-tert-butyl-p-cresol (128-37-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09,GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H370-H373-H401-H411-H410
Precautionary statements  P273-P501-P305+P351+P338-P260-P264-P270-P272-P280-P301+P312+P330-P302+P352+P333+P313+P363-P305+P351+P338+P337+P313-P307+P311-P391-P405
Hazard Codes  Xn,N
Risk Statements  22-36/37/38-36/38-50/53
Safety Statements  26-36-37/39-61-60
RIDADR  3077
WGK Germany  1
RTECS  GO7875000
8-10-23
Autoignition Temperature 878 °F
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29071900
Toxicity LD50 orally in mice: 1040 mg/kg (McOmie)
NFPA 704
1
0 0

Butylated Hydroxytoluene price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 03762 2,6-Di-tert-butyl-4-methylphenol tested according to Ph.Eur. 128-37-0 500g $36.3 2019-12-02 Buy
Sigma-Aldrich 1082708 Butylated hydroxytoluene United States Pharmacopeia (USP) Reference Standard 128-37-0 500mg $399.35 2019-12-02 Buy
TCI Chemical D0228 2,6-Di-tert-butyl-p-cresol >99.0%(GC) 128-37-0 25g $18 2019-12-02 Buy
TCI Chemical D0228 2,6-Di-tert-butyl-p-cresol >99.0%(GC) 128-37-0 500g $33 2019-12-02 Buy
Alfa Aesar A16863 2,6-Di-tert-butyl-4-methylphenol, 99% 128-37-0 250g $24.7 2019-12-02 Buy

Butylated Hydroxytoluene Chemical Properties,Uses,Production

Chemical Properties

Butylated hydroxytoluene(BHT) is white or light yellow crystal. BHT has a melting point of 71°C, a boiling point of 265°C, a relative density of 1.048 (20/4°C), and a refractive index of 1.4859 (75°C). Solubility of BHT at normal temperature: methanol 25, ethanol 25-26, isopropanol 30, mineral oil 30, acetone 40, petroleum ether 50, benzene 40, lard (40-50°C ) 40-50, corn oil and soybean oil 40-50. BHT is insoluble in water, 10NaOH solution, glycerol, and propylene glycol. BHT is odorless, odorless with good thermal stability.

Mammalian physiology

BHT is a phenolic antioxidant. BHT can inhibit lipid peroxidation and cause lung injury in mice and promote tumor growth, which may be due to the metabolites of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-Methylphenol. BHT metabolites have also been reported to cause DNA strand breaks in cultured cells and DNA breaks between nucleosomes (a typical feature of apoptosis). A single intraperitoneal injection of BHT (60mg/kg body weight) into rats caused a significant increase in nuclear DNA methyltransferase activity in the liver, kidney, heart, spleen, brain, and lung.

Chemical Properties

BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. BHT has a very faint, musty, occasional cresylictype odor. BHA and BHT are extensively used in foods as antioxidants. Most fats, oils and fat-containing foods are naturally susceptible to rapid rancification and other oxidative reactions that produce compounds having objectionable taste and odor, making foods containing them unpalatable. Lipid oxidation is autocatalytic and proceeds as a complex of chain reactions, the nature and speed of which vary with the substrate, temperature, light, availability of oxygen and presence or absence of oxidation catalysts. Antioxidants like BHT act as “chain breaks” in the autooxidation processes under the usual conditions of processing, storage and use of fat-containing foods (Burdock, 1997).

Chemical Properties

white crystalline solid

Chemical Properties

BHT is a white to pale yellow crystalline solid or powder.

Chemical Properties

Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

Occurrence

Not reported found naturally.

Uses

Because they prevent rancidity, antioxidants are of great interest to the food industry. For example, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), and EDTA are frequently used to preserve various foods, such as cheese or fried products. Butylated hydroxytoluene is a powerful inhibitor of lipid peroxidation, yet large doses of it can induce oxidative DNA damage and cancer development in the rat forestomach.

Uses

BHT is also known as butylated hydroxy toluene. It is an anti-oxidant that also has preservative and masking capabilities.

Uses

Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.

Uses

Antioxidant 264 as general antioxidants is used widely in polymer materials, petroleum products and food processing industries. Antioxidant 264 is commonly used rubber antioxidant, heat, oxygen aging have some protective effect, but also can inhibit copper harm. This product does not change color, not pollution. Antioxidants 264 high solubility in oil, no precipitation, less volatile, non-toxic and non-corrosive.

Uses

Antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, soaps. Antiskinning agent in paints and inks.

Definition

ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

Preparation

BHT is produced commercially by the alkylation of para-cresol with isobutylene. BHT is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

Production Methods

Prepared by the reaction of p-cresol with isobutene.

General Description

White crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.

Fire Hazard

2,6-Di-tert-butyl-4-methylphenol is combustible.

Pharmaceutical Applications

Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

Contact allergens

This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.

Safety Profile

Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand

Safety

Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
LD50 (guinea pig, oral): 10.7 g/kg
LD50 (mouse, IP): 0.14 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 0.65 g/kg
LD50 (rat, oral): 0.89 g/kg

Potential Exposure

DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.

storage

Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Dissolve BHT in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]

Incompatibilities

Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.

Incompatibilities

Contact with oxidizers may cause fire and explosion hazard.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Butylated Hydroxytoluene Preparation Products And Raw materials

Raw materials

Preparation Products


Butylated Hydroxytoluene Suppliers

Global( 602)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 511 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 586 58
RIANLON CORPORATION
+(86)18522174966
022-83718815 zhanglei@rianlon.com CHINA 88 58
Hebei Xibaijie Biotechnology Co., Ltd.
15203217809
sales@hbxibaijie.com CHINA 409 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19920 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3012 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1892 55
Chemson Industrial (Shanghai) Co., Ltd.
86-21-65208861-ext8007
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Related articles


View Lastest Price from Butylated Hydroxytoluene manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-02 Butylated hydroxytoluene Manufacturer; In stock GMP Factory
128-37-0
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2019-04-05 Butylated Hydroxytoluene 2,6-Di-tert-butyl-4-methylphenol
128-37-0
US $1.00 / kg 1kg 99% High quality Factory Chemwill Asia Co.,Ltd.
2019-12-27 Butylated Hydroxytoluene
128-37-0
US $0.00-0.00 / KG 1KG 99%+ 800 tons Shaanxi Dideu Medichem Co. Ltd

Butylated Hydroxytoluene Spectrum


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