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Vardenafil hydrochloride trihydrate

CAS No.
330808-88-3
Chemical Name:
Vardenafil hydrochloride trihydrate
Synonyms
VARDENAFIL HYDROCHLORIDE TRIHYDRATE;Vardenafil hydrochloride CRS;Vardenafil for system suitability;Vardenafil Hydrochloride (1711010);vardenafil hydrochloride trihyrate;Verdenafil Hydrochloride Trihydrate;2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate;2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate;2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3);IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3)
CBNumber:
CB01230855
Molecular Formula:
C23H35ClN6O5S
Molecular Weight:
543.08
MDL Number:
MFCD08458876
MOL File:
330808-88-3.mol
Last updated:2023-06-08 09:02:14

Vardenafil hydrochloride trihydrate Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O
FDA UNII 5M8S2CU0TS

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H373
Precautionary statements  P260-P264-P270-P301+P310-P314-P405
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933595960
NFPA 704
0
2 0

Vardenafil hydrochloride trihydrate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001647 Vardenafil hydrochloride trihydrate European Pharmacopoeia (EP) Reference Standard 330808-88-3 y0001647 $153 2024-03-01 Buy
Sigma-Aldrich PHR2720 Vardenafil Hydrochloride certified reference material, pharmaceutical secondary standard 330808-88-3 500MG $253 2024-03-01 Buy
Sigma-Aldrich 1711010 Vardenafil for system suitability 330808-88-3 200mg $429 2024-03-01 Buy
Cayman Chemical 14930 Vardenafil (hydrochloride hydrate) ≥98% 330808-88-3 10mg $106 2024-03-01 Buy
Cayman Chemical 14930 Vardenafil (hydrochloride hydrate) ≥98% 330808-88-3 25mg $222 2024-03-01 Buy
Product number Packaging Price Buy
Y0001647 y0001647 $153 Buy
PHR2720 500MG $253 Buy
1711010 200mg $429 Buy
14930 10mg $106 Buy
14930 25mg $222 Buy

Vardenafil hydrochloride trihydrate Chemical Properties,Uses,Production

Description

Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

Uses

Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.

Uses

Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]

Biological Activity

Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

in vitro

Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.

in vivo

Vardenafil dose-dependently potentiates erectile responses to intravenously administered sodium nitroprusside in rabbit. Vardenafil (3 mg/kg, p.o.) results in an improved object discrimination performance in rats. Vardenafil (30 mg/L, p.o.) increases both iNOS and proliferating cell nuclear antigen expression (SM cell replication) in rats, with normalization of the dynamic infusion cavernosometry drop rate and SM/collagen ratio.Vardenafil induces powerful preconditioning-like cardioprotective effect against ischemia/reperfusion injury through opening of mitochondrial K(ATP) channels in the heart of rabbit. Vardenafil protects the ischemic myocardium against reperfusion injury through a mechanism dependent on mitochondrial K(ATP) channel opening.

References

[1] saenz de tejada i1, angulo j, cuevas p, fernández a, moncada i, allona a, lledó e, körschen hg, niewöhner u, haning h, pages e, bischoff e.the phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new pde5 inhibitor vardenafil. int j impot res. 2001 oct;13(5):282-90.

Vardenafil hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 97)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2531 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 gksales1@gk-bio.com China 9333 58
InvivoChem
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Nanjing Doge Biomedical Technology Co., Ltd
+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8474 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33350 58

View Lastest Price from Vardenafil hydrochloride trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE) pictures 2021-07-13 VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE) pictures 2021-07-10 VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Vardenafil hydrochloride trihydrate Spectrum

IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3) Vardenafil for system suitability Verdenafil Hydrochloride Trihydrate Vardenafil hydrochloride CRS 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate vardenafil hydrochloride trihyrate Vardenafil Hydrochloride TrihydrateQ: What is Vardenafil Hydrochloride Trihydrate Q: What is the CAS Number of Vardenafil Hydrochloride Trihydrate Q: What is the storage condition of Vardenafil Hydrochloride Trihydrate Vardenafil Hydrochloride (1711010) 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3) VARDENAFIL HYDROCHLORIDE TRIHYDRATE 2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate 330808-88-3