ChemicalBook >> CAS DataBase List >>Vanoxerine dihydrochloride

Vanoxerine dihydrochloride

CAS No.
67469-78-7
Chemical Name:
Vanoxerine dihydrochloride
Synonyms
I-893;GBR 12909;Vanoxerine;Boxeprazine;GBR129092HCl;Vanoxerine 2HCl;vanoxerine-GBR-12909;I893 dihydrochloride;GBR 12909 DIHYDROCHLORIDE;GBR 12909 (hydrochloride)
CBNumber:
CB9398144
Molecular Formula:
C28H33ClF2N2O
Molecular Weight:
487.03
MDL Number:
MFCD00055193
MOL File:
67469-78-7.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Vanoxerine dihydrochloride Properties

Melting point 221 °C
storage temp. Sealed in dry,Room Temperature
solubility DMSO: >5 mg/mL Solutions freshly prepared daily
form solid
color white
Water Solubility Soluble in DMSO to 50mM. Soluble to 5mM in water with warming.
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
FDA UNII MWO1IP03EV

SAFETY

Risk and Safety Statements

WGK Germany  3
HS Code  2933.59.5300

Vanoxerine dihydrochloride price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D052 GBR 12909 dihydrochloride solid, ≥98% (HPLC) 67469-78-7 25mg $293 2024-03-01 Buy
Sigma-Aldrich D052 GBR 12909 dihydrochloride solid, ≥98% (HPLC) 67469-78-7 100mg $732 2024-03-01 Buy
Sigma-Aldrich 5.05732 GBR 12909 Dihydrochloride - CAS 67469-78-7 - Calbiochem 67469-78-7 10mg $111 2024-03-01 Buy
TCI Chemical G0541 GBR 12909 Dihydrochloride 67469-78-7 50MG $178 2024-03-01 Buy
TCI Chemical G0541 GBR 12909 Dihydrochloride 67469-78-7 250MG $600 2024-03-01 Buy
Product number Packaging Price Buy
D052 25mg $293 Buy
D052 100mg $732 Buy
5.05732 10mg $111 Buy
G0541 50MG $178 Buy
G0541 250MG $600 Buy

Vanoxerine dihydrochloride Chemical Properties,Uses,Production

Description

Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a potent inhibitor that blocks dopamine uptake (IC50 = 1-51 nM). It is more than 100-fold less effective at blocking serotonin or noradrenaline uptake. GBR 12909 effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors. GBR 12909 also inhibits pyrilamine binding to the histamine H1 receptor (IC50 = 18 nM) but poorly inhibits ligand binding to dopamine, adrenergic, acetylcholine, serotonin, and γ-aminobutyric acid receptors. It also blocks ligand binding to sigma receptors in rat brain (IC50 = 48 nM).

Uses

Vanoxerine dihydrochloride is a Dopamine reuptake inhibitor that is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.

Definition

ChEBI: Vanoxerine dihydrochloride is a hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It contains a vanoxerine(2+).

General Description

Vanoxerine dihydrochloride is a potent inhibitor of dopamine active transporter (DAT, Ki = 1 nM, IC50 = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.

Hazard

A poison.

Biological Activity

Potent, competitive inhibitor of dopamine uptake (K i = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC 50 = 48 nM). Centrally active following systemic administration.

Biochem/physiol Actions

Highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.

storage

Room temperature (desiccate)

References

1) Andersen?et al. (1989),?The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action; Eur. J. Pharmacol.,?166?493
2) Contreras?et al. (1990),?GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain; Life Sci.,?47?PL133
3) Yorgason?et al. (2011),?Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection; Neuroscience,?182?125

637-59-2
67469-78-7
Synthesis of Vanoxerine dihydrochloride from 1-Bromo-3-phenylpropane

Vanoxerine dihydrochloride Preparation Products And Raw materials

Global( 125)Suppliers
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ShenZhen Trendseen Biological Technology Co.,Ltd.
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Dayang Chem (Hangzhou) Co.,Ltd.
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Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58

View Lastest Price from Vanoxerine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vanoxerine dihydrochloride pictures 2021-07-20 Vanoxerine dihydrochloride
67469-78-7
US $0.00-0.00 / KG 1g 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
Vanoxerine dihydrochloride pictures 2019-12-20 Vanoxerine dihydrochloride
67469-78-7
US $1.00 / g 1g 99.99% 2tons Career Henan Chemical Co

Vanoxerine dihydrochloride Spectrum

1-(2-[BIS(4-FLUOROPHENYL) METHOXY]ETHYL)-4-(3-PHENYLPROPYL) PIPERAZINE DIHYDROC GBR-12909 DIHYDROCHLORIDE SELECTIVE DOPA MINE UP GBR 12909 GBR 12909 DIHYDROCHLORIDE 1-(2-BIS-((4-FLUOROPHENYL)METHOXY)ETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HCL 1-(2-BIS-[4-FLUOROPHENYL]-METHOXYETHYL)-4-(3-PHENYL-2-PROPYL)PIPERAZINE HYDROCHLORIDE 1-[2-[BIS(4-FLUOROPHENYL)METHOXY]ETHYL]-4-[3-PHENYLPROPYL]PIPERAZINE DIHYDROCHLORIDE Vanoxerine GBR129092HCl vanoxerine-GBR-12909 VANOXERINE DIHYDROCHLORIDE 1-(3-Phenylpropyl)-4-[2-[bis(4-fluorophenyl)methoxy]ethyl]piperazine 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine I-893 Vanoxerine 2HCl Vanoxerine 2HCl (GBR-12909) GBR 12909 (hydrochloride) Vanoxerine Dihydrochloride (GBR-12909) I893 dihydrochloride Piperazine,1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride(1:2) Boxeprazine Vanoxenine dihydrochloride Vanoxerine dihydrochloride(GBR-12909dihydrochloride) 67469-78-7 67469-69-9 C28H34Cl2F2N2O C28H32F2N2O2HCl C28H32F2N2O2ClH Dopamine receptor