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rhapontigenin

rhapontigenin Structure
rhapontigenin structure
CAS No.
500-65-2
Chemical Name:
rhapontigenin
Synonyms
Protigenin;rhapontigenin;3-benzenediol;Rhapontigenin-RM;Rhapontigenin >rhapontigenin USP/EP/BP;Rhapontigenin (Standard);-5-(3-Hydroxy-4-methoxystyryl);COc2ccc(/C=C/c1cc(O)cc(O)c1)cc2O;(E)-4'-Methoxy-3,3',5-stilbenetriol
CBNumber:
CB01309681
Molecular Formula:
C15H14O4
Molecular Weight:
258.27
MDL Number:
MFCD00017718
MOL File:
500-65-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-04 11:17:55
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rhapontigenin Properties

Melting point 189.0 to 193.0 °C
Boiling point 503.6±38.0 °C(Predicted)
Density 1.345±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form powder to crystal
pka 9.17±0.10(Predicted)
color White to Light yellow
Major Application food and beverages
InChI InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+
InChIKey PHMHDRYYFAYWEG-NSCUHMNNSA-N
SMILES C1(O)=CC(/C=C/C2=CC=C(OC)C(O)=C2)=CC(O)=C1
CAS DataBase Reference 500-65-2
FDA UNII 22BG4NNH6W
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
HS Code  2914.50.3000
Storage Class 11 - Combustible Solids

rhapontigenin price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical R0089 Rhapontigenin >98.0%(GC) 500-65-2 100mg $216 2026-04-30 Buy
Cayman Chemical 13293 Rhapontigenin ≥98% 500-65-2 1mg $61 2026-04-30 Buy
Cayman Chemical 13293 Rhapontigenin ≥98% 500-65-2 5mg $137 2026-04-30 Buy
Cayman Chemical 13293 Rhapontigenin ≥98% 500-65-2 10mg $242 2026-04-30 Buy
Cayman Chemical 13293 Rhapontigenin ≥98% 500-65-2 25mg $379 2026-04-30 Buy
Product number Packaging Price Buy
R0089 100mg $216 Buy
13293 1mg $61 Buy
13293 5mg $137 Buy
13293 10mg $242 Buy
13293 25mg $379 Buy

rhapontigenin Chemical Properties, Uses, Production

Description

Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.

Description

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Rheum officinale.

Uses

Rhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1.

Uses

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, rhapontigenin inhibits the proliferation of HepG2 and HL-60R cancer cell lines (IC50 = 48 μM).[Cayman Chemical]

Definition

ChEBI: Rhapontigenin is a stilbenoid.

in vivo

Rhapontigenin (intraperitoneal injection; 25mg/kg) shows significant protection from death due to pulmonary thrombosis in mice, those samples are orally administered 90 min before tail vein injection of epinephrine and collagen[3].

Animal Model:ICR mice[3]
Dosage:25mg/kg
Administration:25mg/kg; intraperitoneal injection
Result:Showed anti-thrombosis activity with 60% protection.

IC 50

CYP1A1: 400 nM (IC50)

References

[1]. chun yj, ryu sy, jeong tc, et al. mechanism-based inhibition of human cytochrome p450 1a1 by rhapontigenin. drug metab dispos. 2001 apr;29(4 pt 1):389-93.
[2]. roberti m1, pizzirani d, simoni d, et al. synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. j med chem. 2003 jul 31;46(16):3546-54.
[3]. roupe ka1, helms gl, halls sc, et al. preparative enzymatic synthesis and hplc analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. j pharm pharm sci. 2005 aug 22;8(3):374-86.

rhapontigenin Preparation Products And Raw materials

Raw materials

Preparation Products

rhapontigenin Suppliers

Global Suppliers ( 209)
Supplier Tel Email Country ProdList Advantage
Chengdu Bioanseis Phytochemicals Co., Ltd. 13518187787 632977132@qq.com China 321 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 18918157536; sales8178@energy-chemical.com China 45000 61
Wuhan Wei Shunda Technology Development Co., Ltd. 86-027-88774375 mwmwhot@163.com China 233 65
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6722 52
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Supplier Advantage
Chengdu Bioanseis Phytochemicals Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Wei Shunda Technology Development Co., Ltd. 65
XiaoGan ShenYuan ChemPharm co,ltd 52
Dalian Meilun Biotech Co., Ltd. 58
Chengdu Biopurify Phytochemicals Ltd. 60

View Latest Price from rhapontigenin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rhapontigenin pictures 2026-08-03 Rhapontigenin
500-65-2
 $51.00-184.00 99.72% 10g TargetMol Chemicals Inc.
Rhapontigenin pictures 2026-05-22 Rhapontigenin
500-65-2
 1kg >98% 1000 kg BINBOBIO CO., LTD.
Rhapontigenin pictures 2024-03-28 Rhapontigenin
500-65-2
 25kg 98% PNP Biotech Co. Ltd
  • Rhapontigenin pictures
  • Rhapontigenin
    500-65-2
  • $51.00-184.00
  • 99.72%
  • TargetMol Chemicals Inc.

rhapontigenin Spectrum

rhapontigenin(500-65-2)1HNMR

500-65-2 (rhapontigenin) Related Search:

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1of4

rhapontigenin (E)-5-[2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene (E)-4'-Methoxy-3,3',5-stilbenetriol (E)-5-(3-Hydroxy-4-Methoxystyryl)benzene-1,3-diol -5-(3-Hydroxy-4-methoxystyryl) 3-benzenediol 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1 5-[(1E)-2-(3-HYDROXY-4-METHOXYPHENYL)ETHENYL]-1;3-BENZENEDIOL 5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol Rhapontigenin > Protigenin 1,3-Benzenediol,5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]- 3,3',5-Trihydroxy-4'-methoxy-trans-stilbene trans-1-(3,5-Dihydroxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethylene rhapontigenin USP/EP/BP COc2ccc(/C=C/c1cc(O)cc(O)c1)cc2O Rhapontigenin-RM Rhapontigenin (Standard) 500-65-2