α-Naphthoflavone
- CAS No.
- 604-59-1
- Chemical Name:
- α-Naphthoflavone
- Synonyms
- BENZOFLAVONE;benzo(h)flavone;-Naphthoflavone;α-naphtoflavone;7,8-BENZOFLAVONE;à-naphthoflavone;A-NAPHTHOFLAVONE;1-Naphthoflavone;α-Naphthoflavone;a-Naphthylflavone
- CBNumber:
- CB0184955
- Molecular Formula:
- C19H12O2
- Molecular Weight:
- 272.3
- MDL Number:
- MFCD00004985
- MOL File:
- 604-59-1.mol
- MSDS File:
- SDS
| Melting point | 153-157 °C (lit.) |
|---|---|
| Boiling point | 375.35°C (rough estimate) |
| Density | 1.1382 (rough estimate) |
| refractive index | 1.5510 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Crystalline Powder or Crystals |
| color | yellow |
| BRN | 210862 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | 5.003 (est) |
| CAS DataBase Reference | 604-59-1(CAS DataBase Reference) |
| FDA UNII | FML65D8PY5 |
| EPA Substance Registry System | 4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl- (604-59-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H413 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330 | |||||||||
| Hazard Codes | Xi,Xn,C,F | |||||||||
| Risk Statements | 68-34-11 | |||||||||
| Safety Statements | 24/25-36/37-45-36/37/39-26-16 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL6250000 | |||||||||
| F | 8 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29143990 | |||||||||
| NFPA 704 |
|
α-Naphthoflavone price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N5757 | α-Naphthoflavone ≥98% | 604-59-1 | 1g | $48.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | N5757 | α-Naphthoflavone ≥98% | 604-59-1 | 5g | $51.66 | 2024-03-01 | Buy |
| TCI Chemical | B0056 | alpha-Naphthoflavone >98.0%(HPLC) | 604-59-1 | 1g | $18 | 2024-03-01 | Buy |
| TCI Chemical | B0056 | alpha-Naphthoflavone >98.0%(HPLC) | 604-59-1 | 5g | $50 | 2024-03-01 | Buy |
| Alfa Aesar | A18542 | alpha-Naphthoflavone, 97% | 604-59-1 | 5g | $51.65 | 2024-03-01 | Buy |
α-Naphthoflavone Chemical Properties,Uses,Production
Chemical Properties
yellow powder
Uses
α-Naphthylflavone is a flavenoid compound that acts on μ-opioid receptors in the treatment of pain. Also acts as a non-steroidal aromatase inhibitor used in breast cancer therapy.
Uses
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
Definition
ChEBI: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Purification Methods
Recrystallise the flavone from EtOH or aqueous EtOH. [IR: Cramer & Windel Chem Ber 89 354 1956, UV Pillon & Massicot Bull Soc Chim Fr 26 1954, Smith J Chem Soc 542
α-Naphthoflavone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from α-Naphthoflavone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2023-11-14 | α-Naphthoflavone
604-59-1
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-11-13 | α-Naphthoflavone
604-59-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | α-Naphthoflavone
604-59-1
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- α-Naphthoflavone
604-59-1
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- α-Naphthoflavone
604-59-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- α-Naphthoflavone
604-59-1
- US $30.00-10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.