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5-Chloro-3-cyanopyridine

5-Chloro-3-cyanopyridine structure

CAS No.: 51269-82-0

Chemical Name:: 5-Chloro-3-cyanopyridine

Synonyms: 5-CHLORONICOTINONITRILE;5-CHLORONICOTINITRILE;5-Chloronicotinontrile;5-Chloro-3-cyanopyridine;3-Chloro-5-cyanopyridine;PYRIDINE DERIVATIVE 51269-82-0;5-chloro-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 5-chloro-;5-CHLORO-3-CYANOPYRIDINE ISO 9001：2015 REACH;6-Chloronicotinonitrile 2-Chloro-5-cyanopyridine

CBNumber:: CB0246774

Molecular Formula:: C6H3ClN2

Molecular Weight:: 138.55

MDL Number:: MFCD03411334

MOL File:: 51269-82-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:48:01

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5-Chloro-3-cyanopyridine Properties

Boiling point	208.3±20.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	-0.50±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933399990

5-Chloro-3-cyanopyridine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR46037	5-Chloronicotinonitrile >98%	51269-82-0	1g	$21	2026-06-04	Buy
Apolloscientific	OR46037	5-Chloronicotinonitrile >98%	51269-82-0	5g	$62	2026-06-04	Buy
Activate Scientific	AS27052	5-Chloronicotinonitrile 97%	51269-82-0	1g	$46	2026-06-04	Buy
Apolloscientific	OR46037	5-Chloronicotinonitrile >98%	51269-82-0	25g	$305	2026-06-04	Buy
Activate Scientific	AS27052	5-Chloronicotinonitrile 97%	51269-82-0	5g	$153	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR46037	1g	$21	Buy
OR46037	5g	$62	Buy
AS27052	1g	$46	Buy
OR46037	25g	$305	Buy
AS27052	5g	$153	Buy

5-Chloro-3-cyanopyridine Chemical Properties, Uses, Production

Uses

5-Chloro-3-cyanopyridine can be used as a building block in the synthesis of other organic compounds.

Synthesis

2457-47-8

544-92-3

51269-82-0

The general procedure for the synthesis of 5-chloro-3-cyanomethylpyridine from 3,5-dichloropyridine and cuprous cyanide was as follows: 3,5-dichloropyridine (4.23 g, 28.6 mmol), cuprous cyanide (CuCN, 3.07 g, 34.3 mmol), and argon-bubbled N-methylpyrrolidone (NMP, 8 mL) were placed in a 40 mL scintillation vial. The reaction system was flushed with argon for 1 min, quickly capped, and the reaction was stirred at 210 °C for 3 h under argon protection. Upon completion of the reaction, the dark brown easily stirred solution was cooled slightly and subsequently poured into concentrated ammonia (NH4OH, 50 mL) under ice bath conditions with vigorous stirring for 5 min. Dichloromethane (DCM, 50 mL) was added and the bilayer mixture was stirred for an additional 5 minutes and filtered. The lower dark amber colored organic layer was retained and the dark blue aqueous layer was extracted with DCM (2 × 50 mL). All organic layers were combined and washed sequentially with NH4OH (1 × 30 mL) and 4M NaCl solution (1 × 30 mL), then dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give an amber-colored oily material containing a large amount of NMP. The residue was separated by rapid chromatography on silica gel (column: 90 mm × 6 mm; eluent: 6:1 hexane/ethyl acetate; fractions of 100 mL were collected; fractions 15-19 were combined) and rotary evaporated at 40 °C to ultimately yield 5-chloro-3-cyanomethylpyridine as bright white microcrystals (891 mg, 22% yield).

References

[1] Patent: US2007/225282, 2007, A1. Location in patent: Page/Page column 37

5-Chloro-3-cyanopyridine Preparation Products And Raw materials

Raw materials

3,5-Dichloropyridine Copper(I) Cyanide N-Methyl-2-pyrrolidone Ammonium hydroxide

Preparation Products

5-Chloro-3-cyanopyridine Suppliers

Global Suppliers ( 101)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266 18918157536;	sales8178@energy-chemical.com	China	45000	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	4006009262 13023226327	hmj@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	4000665055	marketing@accelachem.com	China	10972	64
Tianjin Jinyuda Chemical Co., Ltd.	022-58013646 13011382049	sales@jinyudachem.com	China	1976	55
Baiyin Chengze Chemical Technology Co., Ltd.	+86 943-8535351 13389336721	sales@chengzechem.com	China	300	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Tianjin Jinyuda Chemical Co., Ltd.	55
Baiyin Chengze Chemical Technology Co., Ltd.	58

View Latest Price from 5-Chloro-3-cyanopyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	5-CHLORO-3-CYANOPYRIDINE 51269-82-0	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2022-09-12	5-Chloro-3-cyanopyridine 51269-82-0		1G	98%min	50kg/month	Shanghai Rlavie Technology Co ltd
2021-07-13	5-CHLORO-3-CYANOPYRIDINE 51269-82-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

5-CHLORO-3-CYANOPYRIDINE
51269-82-0
$1.10
99.00%
Dideu Industries Group Limited

5-Chloro-3-cyanopyridine
51269-82-0
98%min
Shanghai Rlavie Technology Co ltd

5-CHLORO-3-CYANOPYRIDINE
51269-82-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Chloro-3-cyanopyridine Spectrum

5-CHLORO-3-CYANOPYRIDINE(51269-82-0)¹HNMR

51269-82-0 (5-Chloro-3-cyanopyridine) Related Search:

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3-Chloro-5-cyanopyridine 5-chloro-3-Pyridinecarbonitrile 5-Chloronicotinontrile 5-CHLORONICOTINITRILE 6-Chloronicotinonitrile 2-Chloro-5-cyanopyridine 5-Chloropyridine-3-carbonitrile, 3-Chloro-5-cyanopyridine 3-Pyridinecarbonitrile, 5-chloro- 5-CHLORO-3-CYANOPYRIDINE ISO 9001：2015 REACH PYRIDINE DERIVATIVE 51269-82-0 5-CHLORONICOTINONITRILE 5-Chloro-3-cyanopyridine 51269-82-0 Heterocycle-Pyridine series