ChemicalBook >> CAS DataBase List >>PHA-680632

PHA-680632

PHA-680632 structure

CAS No.: 398493-79-3

Chemical Name:: PHA-680632

Synonyms: CS-411;PHA-680632 USP/EP/BP;PHA-680632(PHA680632);PHA-680632;PHA680632;PHA 680632;Aurora Kinase,PHA-680632,Inhibitor,inhibit;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

CBNumber:: CB02484639

Molecular Formula:: C28H35N7O2

Molecular Weight:: 501.62

MDL Number:: MFCD16038900

MOL File:: 398493-79-3.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:09

Request For Quotation

PHA-680632 Properties

Melting point	240-242 °C
Boiling point	709.0±60.0 °C(Predicted)
Density	1.294
storage temp.	Store at -20°C
solubility	≥50.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form	Powder
pka	12.26±0.70(Predicted)
FDA UNII	65W8KZU2A4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

PHA-680632 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28381	PHA-680632	398493-79-3	25mg	$724	2024-03-01	Buy
Cayman Chemical	28381	PHA-680632	398493-79-3	50mg	$1085	2024-03-01	Buy
Cayman Chemical	28381	PHA-680632	398493-79-3	5mg	$183	2024-03-01	Buy
Cayman Chemical	28381	PHA-680632	398493-79-3	10mg	$328	2024-03-01	Buy
ChemScene	CS-0194	PHA-680632 98.48%	398493-79-3	10mg	$228	2021-12-16	Buy

Product number	Packaging	Price	Buy
28381	25mg	$724	Buy
28381	50mg	$1085	Buy
28381	5mg	$183	Buy
28381	10mg	$328	Buy
CS-0194	10mg	$228	Buy

PHA-680632 Chemical Properties,Uses,Production

Uses

PHA-680632 is a potent and selective inhibitor of Aurora kinase.

Biological Activity

pha-680632 is a novel and potent inhibitor of aurora kinases, a small family of serine/threonine kinases regulating mitosis in chromosome segregation and cell division, that inhibits the activity of all three aurora kinases with 50% inhibition concentration ic50 values of 27 nm, 135 nm and 120 nm for aurora a, b and c kinases respectively. pha-680632 also cross-reacts with other kinases, including fgfr1, flt3, lck, plk1, stlk2, vegfr2 and vegfr3, to a lesser extent and exhibits much higher ic50 values (390 to 5500 nm) compared to aurora kinases. moreover, pha-680632 potently inhibits proliferation in a wide range of cancer cell types, including hct116, a2780, hl60 and hela cells, with ic50 values ranging from 0.06 to 7.15 μm.soncini c, carpinelli p, gianellini l, fancelli d, vianello p, rusconi l, storici p, zugnoni p, pesenti e, croci v, ceruti r, giorgini ml, cappella p, ballinari d, sola f, varasi m, bravo r, moll j. pha-680632, a novel aurora kinase inhibitor with potent antitumoral activity. clin cancer res. 2006 jul 1;12(13):4080-9.

target

Aurora A

PHA-680632 Preparation Products And Raw materials

Raw materials

Preparation Products

PHA-680632 Suppliers

Global( 87)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28200	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

PHA-680632 Spectrum

PHA-680632(398493-79-3)¹HNMR

398493-79-3(PHA-680632)Related Search:

NU7441 (KU-57788) AZD-8055 (+)-JQ1 MG-132 PD 0332991 HCl

Doxorubicin hydrochloride

1of2

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]- Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)- N-(2,6-diethylphenyl)-3-(4-(4-Methylpiperazin-1-yl)benzaMido)-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(3H)-carboxaMide PHA-680632(PHA680632) N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide PHA-680632;PHA680632;PHA 680632 N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide CS-411 N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide PHA-680632 USP/EP/BP Aurora Kinase,PHA-680632,Inhibitor,inhibit 398493-79-3 Inhibitors Inhibitor