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Danoprevir

Danoprevir Structure
Danoprevir structure
CAS No.
850876-88-9
Chemical Name:
Danoprevir
Synonyms
Danoprevir;RG7227;Intepirdine;R7227;CS-64;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%
CBNumber:
CB02504568
Molecular Formula:
C35H46FN5O9S
Molecular Weight:
731.83
MDL Number:
MFCD16038038
MOL File:
850876-88-9.mol
MSDS File:
SDS
Last updated:2023-12-20 15:36:21
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Danoprevir Properties

Melting point >165°C (dec.)
Density 1.41
storage temp. -20°C Freezer
solubility Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 4.43±0.60(Predicted)
color White to Pale Beige
InChIKey ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
FDA UNII 911Z9PCQ5F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Danoprevir price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24185 Danoprevir ≥95% 850876-88-9 1mg $62 2024-03-01 Buy
Cayman Chemical 24185 Danoprevir ≥95% 850876-88-9 5mg $211 2024-03-01 Buy
Cayman Chemical 24185 Danoprevir ≥95% 850876-88-9 10mg $357 2024-03-01 Buy
TRC D172820 Danoprevir 850876-88-9 5mg $180 2021-12-16 Buy
TRC D172820 Danoprevir 850876-88-9 2.5mg $120 2021-12-16 Buy
Product number Packaging Price Buy
24185 1mg $62 Buy
24185 5mg $211 Buy
24185 10mg $357 Buy
D172820 5mg $180 Buy
D172820 2.5mg $120 Buy

Danoprevir Chemical Properties,Uses,Production

Description

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).

Uses

Danoprevir is a selective and potent inhibitor of Hepatitis C virus.

target

HCV NS3/4A protease

Danoprevir synthesis

154350-29-5
924304-75-6
850876-88-9
Synthesis of Danoprevir from Cyclopropanesulfonamide and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

Danoprevir Preparation Products And Raw materials

Raw materials

Cyclopropanesulfonamide

Preparation Products

Danoprevir Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8474 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9329 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Supplier Advantage
Wuhan Topule Biopharmaceutical Co., Ltd
58
Biochempartner 		58
CONIER CHEM AND PHARMA LIMITED 		58
Career Henan Chemica Co 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
LEAPCHEM CO., LTD. 		58

Related articles

  • The Synthetic method of Danoprevir
  • Danoprevir is an orally administered hepatitis C virus (HCV) NS3 protease inhibitor and recently approved in China for the tre....
  • Dec 20，2023

View Lastest Price from Danoprevir manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Danoprevir pictures 2021-07-13 Danoprevir
850876-88-9
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Danoprevir pictures 2021-07-10 Danoprevir
850876-88-9
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Danoprevir pictures
  • Danoprevir
    850876-88-9
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Danoprevir pictures
  • Danoprevir
    850876-88-9
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Danoprevir Spectrum

RG7227, ITMN-191, RO5190591(850876-88-9)1HNMR

850876-88-9(Danoprevir)Related Search:

Everolimus Daclatasvir ABT 737 Telaprevir Trametinib
Rapamycin

1of2

RG7227, ITMN-191, RO5190591 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester ITMN-191 Danoprevir(ITMN-191) 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191) Danoprevir, >=98% Itmn-191 Danoprevir (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate R7227 RO5190591 Danoprevir (RG7227) Danoprevir(ITMN-191, RG7227) Danoprevir - ITMN 191 | RG 7227 | R 7227 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio CS-64 ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191 (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate RG72277 (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate Danpprevir Danoprevir ( ITMN191, R7227 Intepirdine RG7227 Danoprevir Danoprevir ITMN-191 Selleck HCV Protease inhibitor Danoprevir(ITMN-191)/RG7227,RO5190591 850876-88-9 Inhibitor Inhibitors Coronavirus