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LLY-507

LLY-507 Structure
LLY-507 structure
CAS No.
1793053-37-8
Chemical Name:
LLY-507
Synonyms
LLY-507;CS-2196;LLY-507(CHEMBL3414623);LLY-507; LLY507;LLY 507;5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrol;3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide;5-Cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl}-N-[3-(1-pyrrolidinyl)propyl]-3-biphenylcarboximidic acid;5-Cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide;5-cyano-2'-(4-(2-(3-methyl-1h-indol-1-yl)ethyl)piperazin-1-yl)-n-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide;5-Cyano-2'-(4-(2-(3-methyl-1H-indol-1-yl)ethyl)piperazin-1-yl)-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide
CBNumber:
CB03051582
Molecular Formula:
C36H42N6O
Molecular Weight:
574.76
MDL Number:
MFCD28902312
MOL File:
1793053-37-8.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

LLY-507 Properties

storage temp. Store at -20°C
solubility ≥57.5 mg/mL in DMSO; insoluble in H2O; ≥54.7 mg/mL in EtOH
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

LLY-507 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16441 LLY-507 ≥98% 1793053-37-8 1mg $57 2024-03-01 Buy
Cayman Chemical 16441 LLY-507 ≥98% 1793053-37-8 5mg $166 2024-03-01 Buy
Cayman Chemical 16441 LLY-507 ≥98% 1793053-37-8 10mg $302 2024-03-01 Buy
Cayman Chemical 16441 LLY-507 ≥98% 1793053-37-8 25mg $670 2024-03-01 Buy
TRC L468905 LLY-507 1793053-37-8 1mg $55 2021-12-16 Buy
Product number Packaging Price Buy
16441 1mg $57 Buy
16441 5mg $166 Buy
16441 10mg $302 Buy
16441 25mg $670 Buy
L468905 1mg $55 Buy

LLY-507 Chemical Properties,Uses,Production

Uses

LLY-507 is a small molecule inhibitor of SMYD2 (lysine N-methyltransferase), preventing p53 lysine methylation in squamous cell carcinoma cells. Shows a >100-fold selective for SMYD2 over 27 other protein methyltransferases (and non-methyltransferase) targets.

Biological Activity

lly-507 is a potent inhibitor of smyd2.smyd2, a lysine methyltransferase, catalyzes the monomethylation of several protein substrates including p53. smyd2 is reported to be overexpressed in a significant percentage of esophageal squamous primary carcinomas, and such overexpression related with poor patient survival.

in vitro

lly-507 has been identified as a cell-active, potent small molecule inhibitor of smyd2. lly-507 was found to be >100-fold selective for smyd2 over a broad range of methyltransferase and non-methyltransferase targets. the crystal structure of smyd2 in complex with lly-507 showed it bound in the substrate peptide binding pocket. lly-507 was active in cells as demonstrated by the reduction of smyd2-induced monomethylation of p53 lys(370) at submicromolar concentrations. furthermore, ms-based proteomics indicated that cellular histone methylation levels were not affected by smyd2 inhibition with lly-507 significantly, and subcellular fractionation studies showed that smyd2 was primarily cytoplasmic, indicating that smyd2 targeted a small subset of histones. moreover, lly-507 was able to inhibit the proliferation of several liver, esophageal, as well as breast cancer cell lines in a dose-dependent manner [1].

IC 50

< 15 nm

References

[1] nguyen h, et al. lly-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase smyd2. j biol chem. 2015 may 29;290(22):13641-13653.

LLY-507 Preparation Products And Raw materials

Raw materials

Preparation Products

LLY-507 Suppliers

Global( 82)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4604 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58

View Lastest Price from LLY-507 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LLY-507 pictures 2019-12-24 LLY-507
1793053-37-8
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
5-Cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl}-N-[3-(1-pyrrolidinyl)propyl]-3-biphenylcarboximidic acid pictures 2019-12-23 5-Cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl}-N-[3-(1-pyrrolidinyl)propyl]-3-biphenylcarboximidic acid
1793053-37-8
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • LLY-507 pictures
  • LLY-507
    1793053-37-8
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

LLY-507 Spectrum

LLY-507(1793053-37-8)MS

1793053-37-8(LLY-507)Related Search:

AZD6738 SGC707 MS023 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Enasidenib Epacadostat (INCB024360) indoleaMine-2,3-dioxygenase inhibitor INCB024360 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide DBeQ

1of2

LLY-507 5-Cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrol LLY-507(CHEMBL3414623) LLY-507; LLY507;LLY 507 CS-2196 5-Cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl}-N-[3-(1-pyrrolidinyl)propyl]-3-biphenylcarboximidic acid 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide [1,1'-Biphenyl]-3-carboxamide, 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]- 5-Cyano-2'-(4-(2-(3-methyl-1H-indol-1-yl)ethyl)piperazin-1-yl)-N-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide 5-cyano-2'-(4-(2-(3-methyl-1h-indol-1-yl)ethyl)piperazin-1-yl)-n-(3-(pyrrolidin-1-yl)propyl)-[1,1'-biphenyl]-3-carboxamide 1793053-37-8 C36H42N6O