CHOLIC-2,2,4,4-D4 ACID
- CAS No.
- 116380-66-6
- Chemical Name:
- CHOLIC-2,2,4,4-D4 ACID
- Synonyms
- D4-Cholic Acid;Cholic-d4 Acid;2H4]-Cholic Acid;Cholic acid-2,2,4,4-d;Cholic acid-D4;Cholic Acid -[d4] (Solution);Cholic acid (2,2,4,4-D?, 98%);Cholic Acid-d4 MaxSpec? Standard;Cholic acid-2,2,4,4-d4;CHOLICACID(2,2,4,4-D4) IN METHANOL
- CBNumber:
- CB0334837
- Molecular Formula:
- C24H36D4O5
- Molecular Weight:
- 412.6
- MDL Number:
- MFCD00209701
- MOL File:
- 116380-66-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Cholic acid-2,2,4,4-d 98 atom % D, 98% (CP) | 614149 | 500mg | $1860 |
| Cholic Acid-d4 ≥95% | 20849 | 1mg | $90 |
| Cholic Acid-d4 ≥95% | 20849 | 5mg | $132 |
| Cholic Acid-d4 MaxSpec® Standard ≥95% | 31348 | 100μg | $143 |
| Cholic Acid-d4 ≥95% | 20849 | 10mg | $246 |
| Melting point | 200-201°C (lit.) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
| form | Solid |
| color | White to Off-White |
| InChIKey | BHQCQFFYRZLCQQ-XJNZYMKVNA-N |
| SMILES | [2H]C1([2H])C[C@]2(C)[C@H]3C[C@H](O)[C@]4(C)[C@H](CC[C@H]4[C@@H]3[C@H](O)C[C@@H]2C([2H])([2H])[C@@H]1O)[C@H](C)CCC(O)=O |
| FDA UNII | 88X15G5Z03 |
| UNSPSC Code | 41141802 |
| NACRES | NA.12 |
| CAS Number Unlabeled | 81-25-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H370 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P303+P361+P353-P307+P311-P321-P370+P378-P403+P235-P405-P501 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
CHOLIC-2,2,4,4-D4 ACID price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 614149 | Cholic acid-2,2,4,4-d 98 atom % D, 98% (CP) | 116380-66-6 | 500mg | $1860 | 2026-04-30 | Buy |
| Cayman Chemical | 20849 | Cholic Acid-d4 ≥95% | 116380-66-6 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 20849 | Cholic Acid-d4 ≥95% | 116380-66-6 | 5mg | $132 | 2026-04-30 | Buy |
| Cayman Chemical | 31348 | Cholic Acid-d4 MaxSpec® Standard ≥95% | 116380-66-6 | 100μg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 20849 | Cholic Acid-d4 ≥95% | 116380-66-6 | 10mg | $246 | 2026-04-30 | Buy |
CHOLIC-2,2,4,4-D4 ACID Chemical Properties,Uses,Production
Description
Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; ) and taurocholic acid (TCA; ), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; ) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.
Uses
Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells.
Definition
ChEBI: Cholic acid-2,2,4,4-d4 is a bile acid.
References
[1] TANJA M ARENAC Momir M. Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.[J]. Frontiers in Pharmacology, 2018: 939. DOI: 10.3389/fphar.2018.00939
[2] MARY C. HUNT Stefan E H A Marina I Siponen. The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism[J]. Biochimica et biophysica acta. Molecular basis of disease, 2012, 1822 9: Pages 1397-1410. DOI: 10.1016/j.bbadis.2012.03.009
[3] CHRISTOPHER STALEY. Interaction of gut microbiota with bile acid metabolism and its influence on disease states[J]. Applied Microbiology and Biotechnology, 2016, 101 1: 47-64. DOI: 10.1007/s00253-016-8006-6
[4] JOSEPH A SORG A L S. Bile salts and glycine as cogerminants for Clostridium difficile spores.[J]. Journal of Bacteriology, 2008: 2505-2512. DOI: 10.1128/jb.01765-07
[5] K UCHIDA N T Y Nomura. Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of rats.[J]. Journal of biochemistry, 1980, 87 1: 187-194. DOI: 10.1093/oxfordjournals.jbchem.a132724
[6] PENGXIANG QU. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates.[J]. Cell metabolism, 2023, 35 5: 742-757.e10. DOI: 10.1016/j.cmet.2023.03.013
CHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials
Raw materials
Preparation Products
CHOLIC-2,2,4,4-D4 ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 9886 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 26716 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9679 | 58 |
| TianJin Alta Scientific Co., Ltd. | 022-65378550-8551 | contact@altascientific.com | China | 2773 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18421 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Artis Biotech Co. Ltd. | 19138486554; 18108108965 | sales@artisbio.com | China | 2354 | 58 |
View Lastest Price from CHOLIC-2,2,4,4-D4 ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Cholic acid-d4
116380-66-6
|
US $0.00 / removed | 10g | TargetMol Chemicals Inc. |
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- Cholic acid-d4
116380-66-6
- US $0.00 / removed
- TargetMol Chemicals Inc.
