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FEXOFENADINE HYDROCHLORIDE

FEXOFENADINE HYDROCHLORIDE structure

CAS No.: 138452-21-8

Chemical Name:: FEXOFENADINE HYDROCHLORIDE

Synonyms: Fexofendine Hcl;FEXOFENADINE HCL;Fexofenadine Hydrochloride (200 mg);terfenidine carboxylate hydrochloride;CARBOXYTERFENADINE,TERFENADINECARBOXYLATE;Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai);2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid;2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;(+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE;ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE

CBNumber:: CB0340913

Molecular Formula:: C32H40ClNO4

Molecular Weight:: 538.12

MDL Number:: MFCD00865710

MOL File:: 138452-21-8.mol

Last updated:2023-05-04 17:34:33

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FEXOFENADINE HYDROCHLORIDE Properties

storage temp.	−20°C
solubility	DMSO: 32 mg/mL, soluble
form	solid
color	white

SAFETY

Risk and Safety Statements

WGK Germany	3

FEXOFENADINE HYDROCHLORIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Medical Isotopes, Inc.	10243	Fexofenadine HCl	138452-21-8	100mg	$850	2021-12-16	Buy

Product number	Packaging	Price	Buy
10243	100mg	$850	Buy

FEXOFENADINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

The metabolite of seldane (terfenadine), fexofenadine, was launched in the USA. A histamine H₁ receptor antagonist, fexofenadine is more effect than its parent compound without the associated side-effects.

Originator

Sepracor (USA)

Uses

Fexofenadine HCl (Allegra) is a selective, specific H1 antagonist that is structurally related to the butyrophenone tranquilizer haloperidol. It is the active carboxylic acid metabolite of terfenadine (no longer commercially available in the United States). It binds mainly to the peripheral H1 receptors, with minimal crossing of the blood–brain barrier and hence minimal sedative effects. Fexofenadine lacks the cardiotoxic effects of its parent drug, terfenadine. However, it has been associated with increased QT interval, syncope, and ventricular arrhythmia in at least one susceptible patient with preexisting cardiovascular risk. To date, no significant interactions have been demonstrated with fexofenadine when administered concomitantly with azole antifungals or macrolide antibiotics. Indicated for seasonal allergic rhinitis and chronic idiopathic urticaria.

Uses

Anti-histamine

Definition

ChEBI: Fexofenadine hydrochloride is a diarylmethane.

brand name

Allegra

Dosage forms

60 mg PO b.i.d.

FEXOFENADINE HYDROCHLORIDE synthesis

Synthesis of FEXOFENADINE HYDROCHLORIDE from Methyl-4-4(4-hydroxy diphenyl-methyl)-piperidine-1-oxobutyl-2-2-dimethyl phenyl

FEXOFENADINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Fexofenadine

Preparation Products

FEXOFENADINE HYDROCHLORIDE Suppliers

Global( 65)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323967 +86-18015559028	sales1@artkmedchem.com	China	8920	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
XiaoGan ShenYuan ChemPharm co,ltd	15527768850	1791901229@qq.com	China	8849	52
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
sgtlifesciences pvt ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Suzhou ARTK Medchem Co., Ltd.	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
XiaoGan ShenYuan ChemPharm co,ltd	52
Sinopharm Chemical Reagent Co,Ltd.	79
Beijing HuaMeiHuLiBiological Chemical	58

138452-21-8(FEXOFENADINE HYDROCHLORIDE)Related Search:

FEXOFENADINE HYDROCHLORIDE Terfenadine alpha,alpha-Diphenyl-4-piperidinomethanol Diphenylpiperidin-4-ylmethanol hydrochloride Fexofenadine hydrochloride

Acetic acid Fexofenadine 2-Phenylisobutyric acid THIOGLYCOLIC ACID N-BUTYL ESTER 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE

(2RS)-2-(4-BUTYLPHENYL)PROPANOIC ACID Benzeneacetic acid, 4-butyl--alpha--methyl-, (-alpha-S)- (9CI) 4-N-BUTYLPHENETHYL ALCOHOL 4-(TERT-BUTYL)-ALPHA-METHYLBENZYL ALCOHOL (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID

4-(diphenylmethyl)piperidine 2-(4-PIPERIDYL)-2-PROPANOL PHENYL-PIPERIDIN-4-YL-METHANOL

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terfenidine carboxylate hydrochloride ALPHA,ALPHA-DIMETHYL-4-[1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL]BUTYL]-BENZENEACETIC ACID HYDROCHLORIDE 2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride FEXOFENADINE HCL CARBOXYTERFENADINE,TERFENADINECARBOXYLATE Fexofendine Hcl (+)-4-(1-HYDROXY-4-(4-HYDROXYDIPHENYLMETHYL)1-PIPERIDINYL)-BUTYL)a,a-(DIMETHYL BENZENE ACETIC ACID HYDROCHLORIDE Fexofenadine Hydrochloride (200 mg) Fexofenadine Hydrochloride (200 mg)F1E2890.996mg/mg(ai) Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethyl-, hydrochloride (1:1) 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]butyl]phenyl]-2-methylpropanoic acid 138452-21-8 C32H39NO4.HCl