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T0901317

T0901317
T0901317 structure
CAS No.
293754-55-9
Chemical Name:
T0901317
Synonyms
T 1317;T0901317;TO-901317;T0901317 - CAS 293754-55-9 - Calbiochem;N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl];N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE;N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE;BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-
CBNumber:
CB0368768
Molecular Formula:
C17H12F9NO3S
Formula Weight:
481.33
MOL File:
293754-55-9.mol

T0901317 Properties

storage temp. 
−20°C
form 
Light beige solid
InChIKey
SGIWFELWJPNFDH-UHFFFAOYSA-N

SAFETY

WGK Germany  3

T0901317 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T2320 T0901317 ≥98% 293754-55-9 5mg $90.6 2018-11-13 Buy
Sigma-Aldrich 575310 T0901317 293754-55-9 10mg $141 2018-11-20 Buy
Cayman Chemical 71810 T0901317 ≥98% 293754-55-9 50mg $94 2018-11-13 Buy
Cayman Chemical 71810 T0901317 ≥98% 293754-55-9 10mg $25 2018-11-13 Buy
Cayman Chemical 71810 T0901317 ≥98% 293754-55-9 100mg $163 2018-11-13 Buy

T0901317 Chemical Properties,Uses,Production

Uses

The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

T0901317 Preparation Products And Raw materials

Raw materials

Preparation Products


T0901317 Suppliers

Global( 52)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu Henghui Pharm Tec Co. Ltd.
13540674322 15828370308,QQ:2879822141
028-89481236 service@2hpharm.com CHINA 121 55
ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 16534 60
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840,18511084608
010-60605840 psaitong@jm-bio.com China 1727 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2928 55
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15926 69
BOC Sciences
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Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9947 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 25106 65
Shanghai Hekang Biotechnology Co., Ltd. 18939837085
2880152144(QQ) cheminstock@gmail.com China 1534 55
Hygeia (Chengdu) pharmaceutical technique Co., Ltd +86-028- 84502008
+86-028-66476329 sales@hygeiapharm.com China 237 55

293754-55-9(T0901317)Related Search:


  • T0901317 - CAS 293754-55-9 - Calbiochem
  • N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE
  • T0901317
  • TO-901317
  • BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-
  • T 1317
  • N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]
  • N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE
  • 293754-55-9
  • -
  • PPAR and RXR Regulators
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Inhibitors
  • C17H12NSO3F9
  • C17H12F9NO3S
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
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