DEXAMETHASONE SODIUM PHOSPHATE
- CAS No.
- 312-93-6
- Chemical Name:
- DEXAMETHASONE SODIUM PHOSPHATE
- Synonyms
- EGP437;EGP 437;EGP-437;wymesone;neodecadron;betnelanphosphate;oradexonphosphate;Hexadrol phosphate;examethasonephosphate;dexamethasonephosphate
- CBNumber:
- CB0500878
- Molecular Formula:
- C22H30FO8P
- Molecular Weight:
- 472.44
- MDL Number:
- MFCD00152787
- MOL File:
- 312-93-6.mol
- MSDS File:
- SDS
| Melting point | 154-157°C |
|---|---|
| Boiling point | 669.6±65.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 1.67±0.10(Predicted) |
| form | Solid |
| color | White to Light Brown |
| Stability | Hygroscopic, Moisture Sensitive |
| FDA UNII | 2BP70L44PR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H361 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 62 |
| HS Code | 2937220000 |
| Toxicity | dni-rat-ipr 3 mg/kg JOENAK 62,527,74 |
DEXAMETHASONE SODIUM PHOSPHATE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1628 | Dexamethasone Phosphate Pharmaceutical Secondary Standard; Certified Reference Material | 312-93-6 | 500mg | $342 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1177000 | Dexamethasone phosphate United States Pharmacopeia (USP) Reference Standard | 312-93-6 | 500mg | $261.6 | 2024-03-01 | Buy |
| TRC | D298835 | Dexamethasone Phosphate | 312-93-6 | 25mg | $105 | 2021-12-16 | Buy |
| Matrix Scientific | 096162 | Dexamethasone 21-phosphate 95+% | 312-93-6 | 250mg | $742 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0005112 | DEXAMETHASONE PHOSPHATE 95.00% | 312-93-6 | 25MG | $750.75 | 2021-12-16 | Buy |
DEXAMETHASONE SODIUM PHOSPHATE Chemical Properties,Uses,Production
Originator
Decadron Phosphate,MS and D,US,1959
Uses
A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
Definition
ChEBI: A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Manufacturing Process
A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36
ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of
triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g
of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21-
methanesulfonate and 20 ml of acetonitrile. The mixture was heated under
reflux for four hours and then evaporated under reduced pressure to a volume
of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate
triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture
treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The
precipitated inorganic phosphates were removed by suction filtration and
washed thoroughly with methanol. The combined filtrates were evaporated
under reduced pressure to a volume of 12 ml and treated with 30 ml of
methanol. The resulting cloudy solution was clarified by filtration through
diatomaceous earth. The volume of the filtrate was brought to 40 ml by the
addition of methanol, and 120 ml of ether was added with stirring. The
precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by
suction filtration, and washed with acetone and then with ether. The weight of
the air-dried material was 3.06 g.
brand name
Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).
Therapeutic Function
Glucocorticoid
Safety Profile
An experimental teratogen. Otherexperimental reproductive effects. Mutation data reported.When heated to decomposition it emits toxic fumes of F-and POx.
DEXAMETHASONE SODIUM PHOSPHATE Preparation Products And Raw materials
DEXAMETHASONE SODIUM PHOSPHATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
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