TOPOTECAN-D6
- CAS No.
- 1044904-10-0
- Chemical Name:
- TOPOTECAN-D6
- Synonyms
- Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;Topotecan dihydrochloride salt;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- CBNumber:
- CB0649948
- Molecular Formula:
- C23H23N3O5
- Molecular Weight:
- 421.45
- MDL Number:
- MOL File:
- 1044904-10-0.mol
| Melting point | 213-218°C (dec) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | aqueous acid: soluble; DMSO: slightly; Methanol: soluble |
| form | A solid |
| Stability | Hygroscopic |
| CAS DataBase Reference | 1044904-10-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H341 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
TOPOTECAN-D6 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29082 | Topotecan-d6 | 1044904-10-0 | 500μg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 29082 | Topotecan-d6 | 1044904-10-0 | 1mg | $299 | 2024-03-01 | Buy |
| Usbiological | T8067-11 | Topotecan-d6 | 1044904-10-0 | 1mg | $460 | 2021-12-16 | Buy |
| TRC | T542502 | Topotecan-d6 | 1044904-10-0 | 10mg | $1455 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0005320 | TOPOTECAN-D6 95.00% | 1044904-10-0 | 100MG | $1871.1 | 2021-12-16 | Buy |
TOPOTECAN-D6 Chemical Properties,Uses,Production
Description
Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.
Chemical Properties
Light Yellow to Greenish Powder
Uses
Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.
Uses
Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic
TOPOTECAN-D6 Preparation Products And Raw materials
Raw materials
Preparation Products
TOPOTECAN-D6 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9288 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Hefei Molake Biotechnology Co., Ltd. | 0551-66336380 18956014586 | 983438788@qq.com | China | 2077 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 8192 | 58 |