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TOPOTECAN-D6

CAS No.
1044904-10-0
Chemical Name:
TOPOTECAN-D6
Synonyms
Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;Topotecan dihydrochloride salt;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CBNumber:
CB0649948
Molecular Formula:
C23H23N3O5
Molecular Weight:
421.45
MDL Number:
MOL File:
1044904-10-0.mol

TOPOTECAN-D6 Properties

Melting point 213-218°C (dec)
storage temp. -20°C Freezer
CAS DataBase Reference 1044904-10-0

TOPOTECAN-D6 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29082 Topotecan-d6 1044904-10-0 500μg $140 2023-01-06 Buy
Cayman Chemical 29082 Topotecan-d6 1044904-10-0 1mg $266 2023-01-06 Buy
Usbiological T8067-11 Topotecan-d6 1044904-10-0 1mg $460 2021-12-16 Buy
TRC T542502 Topotecan-d6 1044904-10-0 10mg $1455 2021-12-16 Buy
American Custom Chemicals Corporation RDL0005320 TOPOTECAN-D6 95.00% 1044904-10-0 100MG $1871.1 2021-12-16 Buy
Product number Packaging Price Buy
29082 500μg $140 Buy
29082 1mg $266 Buy
T8067-11 1mg $460 Buy
T542502 10mg $1455 Buy
RDL0005320 100MG $1871.1 Buy

TOPOTECAN-D6 Chemical Properties,Uses,Production

Description

Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical Properties

Light Yellow to Greenish Powder

Uses

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

Uses

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

TOPOTECAN-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

TOPOTECAN-D6 Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 18938635012 sales@regentsciences.com China 8791 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684 sales@rrkchem.com China 54557 58
Hefei Molake Biotechnology Co., Ltd. 18055148196 983438788@qq.com China 2070 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18717932730 sales@chemegen.com China 11292 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 45003 58
Shanghai isotope chemical co.,ltd 16621736678 3067237646@qq.com China 4038 58

1044904-10-0(TOPOTECAN-D6)Related Search:

TOPOTECAN-D6 (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione SKF-104864A-d6 (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hycamtin-d6 NSC-609669-d6 (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione [2H6]-Topotecan Topotecan dihydrochloride salt 1044904-10-0 C23H17D6N3O5 C23H17N3O5D6 Heterocycles Isotope Labelled Compounds Inhibitors Intermediates & Fine Chemicals Isotope Labeled Compounds Pharmaceuticals