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ChemicalBook >> CAS DataBase List >> TOPOTECAN-D6

TOPOTECAN-D6

TOPOTECAN-D6 price.
  • $158 - $1871.1
  • Product name: TOPOTECAN-D6
  • CAS: 1044904-10-0
  • MF: C23H23N3O5
  • MW: 421.45
  • EINECS:
  • MDL Number:
  • Synonyms:TOPOTECAN-D6;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;SKF-104864A-d6;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Hycamtin-d6;NSC-609669-d6;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;[2H6]-Topotecan
Price8 Properties Safety Information Description
8 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 500μg
  • 1MG
  • 10MG
  • 100MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0005320
  • Product descriptionTOPOTECAN-D6 95.00%
  • Packaging1MG
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0005320
  • Product descriptionTOPOTECAN-D6 95.00%
  • Packaging10MG
  • Price$739.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0005320
  • Product descriptionTOPOTECAN-D6 95.00%
  • Packaging100MG
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29082
  • Product descriptionTopotecan-d6
  • Packaging500μg
  • Price$158
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29082
  • Product descriptionTopotecan-d6
  • Packaging1mg
  • Price$299
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product numberD4415
  • Product descriptionTopotecan-d6
  • Packaging1mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberT542502
  • Product descriptionTopotecan-d6
  • Packaging10mg
  • Price$1455
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberT8067-11
  • Product descriptionTopotecan-d6
  • Packaging1mg
  • Price$460
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0005320 TOPOTECAN-D6 95.00% 1MG $545 2021-12-16 Buy
American Custom Chemicals Corporation RDL0005320 TOPOTECAN-D6 95.00% 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation RDL0005320 TOPOTECAN-D6 95.00% 100MG $1871.1 2021-12-16 Buy
Cayman Chemical 29082 Topotecan-d6 500μg $158 2024-03-01 Buy
Cayman Chemical 29082 Topotecan-d6 1mg $299 2024-03-01 Buy
Medical Isotopes, Inc. D4415 Topotecan-d6 1mg $750 2021-12-16 Buy
TRC T542502 Topotecan-d6 10mg $1455 2021-12-16 Buy
Usbiological T8067-11 Topotecan-d6 1mg $460 2021-12-16 Buy

Properties

Melting point :213-218°C (dec)
storage temp. :-20°C Freezer
solubility :aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form :A solid
Stability :Hygroscopic
CAS DataBase Reference :1044904-10-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

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Suppliers and manufacturers

J & K SCIENTIFIC LTD. Chemsky（shanghai）International Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shenzhen Regent Biochemical Technology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd Shenzhen Polymeri Biochemical Technology Co., Ltd. Hefei Molake Biotechnology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical Shanghai Ruipu Medical Technology Co., Ltd