Gepirone
- CAS No.
- 83928-76-1
- Chemical Name:
- Gepirone
- Synonyms
- GEPIRONE;Gepirona;Gepironum;Gepirone er;Gepirone HCl;Gepirone [inn];Gepironum [latin];Gepirona [spanish];ORG-13011(Gepirone);Gepirone(ORG-13011)
- CBNumber:
- CB11011279
- Molecular Formula:
- C19H29N5O2
- Molecular Weight:
- 359.47
- MDL Number:
- MFCD00868196
- MOL File:
- 83928-76-1.mol
- MSDS File:
- SDS
| Melting point | 106-108°C |
|---|---|
| Boiling point | 562.3±60.0 °C(Predicted) |
| Density | 1.142±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 7.72±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | JW5Y7B8Z18 |
| ATC code | N06AX19 |
Gepirone price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G365000 | Gepirone | 83928-76-1 | 250mg | $845 | 2021-12-16 | Buy |
| Matrix Scientific | 099512 | 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione 95% | 83928-76-1 | 250mg | $925 | 2021-12-16 | Buy |
| AK Scientific | 2913AC | 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione | 83928-76-1 | 1g | $1023 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FO65115 | Gepirone | 83928-76-1 | 10mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FO65115 | Gepirone | 83928-76-1 | 50mg | $225 | 2021-12-16 | Buy |
Gepirone Chemical Properties,Uses,Production
Description
Gepirone is a chemical analogue of buspirone and also acts as a partial agonist at 5-HT1A receptors. It is active in animal models predictive of anxiolytic action and also shows antidepressant activity in preclinical studies. With long-term administration, gepirone downregulates 5-HT2 receptors, which is a property common to nearly all antidepressant drugs (Stahl 1994). This dual action, suggesting both anxiolytic and antidepressant effects, is typical of many compounds acting at 5-HT1A receptors and may indicate that such compounds may be useful in the treatment of mixed anxiety and depression (Stahl, in press).
Preliminary phase II clinical data have shown that gepirone is an effective anxiolytic that significantly reduces both psychic and somatic symptoms of generalized anxiety disorder. Like buspirone, gepirone does not impair memory, verbal fluency, or psychomotor performance (Harto and Branconnier 1988).
Uses
Gepirone is an antidepressant and anxiolytic of the azapirone class. It acts as a selective partial agonist of the 5-HT1A receptor.
Definition
ChEBI: Gepirone is a N-arylpiperazine.
Gepirone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chongqing Botao Biotechnology Co., LTD | 15223382610 | danny@chemdad.com | China | 241 | 58 |