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Buspirone hydrochloride

Buspirone hydrochloride
Buspirone hydrochloride structure
CAS No.
33386-08-2
Chemical Name:
Buspirone hydrochloride
Synonyms
Narol;bespar;axoren;travin;Ansial;censpar;lucelan;Ansiced;buspinol;mj9022-1
CBNumber:
CB8367136
Molecular Formula:
C21H32ClN5O2
Formula Weight:
421.96
MOL File:
33386-08-2.mol

Buspirone hydrochloride Properties

Melting point:
201.5-202.50C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Freely soluble in water and in methanol, practically insoluble in acetone.
form 
neat
Water Solubility 
Soluble in methanol (50 mg/ml), water (partly), DMSO (100 mM).
CAS DataBase Reference
33386-08-2(CAS DataBase Reference)
FDA UNII
207LT9J9OC
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H301-H315-H319-H335
Precautionary statements  P261-P280a-P301+P310a-P305+P351+P338-P405-P501a-P210-P260-P280-P301+P310-P311
Hazard Codes  T,Xn,F
Risk Statements  25-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  45-36-26-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  CL9915000
HazardClass  6.1
HS Code  29335995
Toxicity LD50 i.p. in rats: 136 mg/kg (Allen)

Buspirone hydrochloride price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B-054 Buspirone hydrochloride solution 33386-08-2 054-1ml $60.6 2020-08-18 Buy
Sigma-Aldrich 1078802 Buspirone hydrochloride United States Pharmacopeia (USP) Reference Standard 33386-08-2 200mg $366 2020-08-18 Buy
Alfa Aesar J60476 Buspirone hydrochloride 33386-08-2 1g $48.7 2020-06-24 Buy
Alfa Aesar J60476 Buspirone hydrochloride 33386-08-2 5g $183 2020-06-24 Buy
Cayman Chemical 22028 Buspirone (hydrochloride) ≥98% 33386-08-2 5mg $199 2020-06-24 Buy

Buspirone hydrochloride Chemical Properties,Uses,Production

Description

Buspirone hydrochloride is an anxiolytic agent indicated for the management of anxiety disorders with or without accompanying depression. In contrast to the benzodiazepines, buspirone does not interact with alcohol, and lacks sedative, anticonvulsant, and muscle relaxant effects, and abuse potential.

Chemical Properties

White Solid

Originator

Mead Johnson (USA)

Uses

Non-benzodiazepine anxiolitic; 5-hydroxytryptamine (5-HT1) receptor agonist.

Uses

Non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist.

Uses

anxiolitic;serotonin receptor agonist

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of buspirone and hydrogen chloride.

Manufacturing Process

There is the 3 methods for preparing of 8-azaspiro(4.5)decane-7,9-dione, 8- (4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl) monohydrochloride (U.S. Patent 3,717,634). One of them is follows: a mixture of 0.1 mole of the substituted glutaric anhydride, 0.1 mole of l-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine (U.S. Pat. 3,398151), and 300 ml of pyridine was refluxed until imide formation was completed. The degree of reaction was readily followed by taking an aliquot portion of the reaction mixture, removing the solvent, and obtaining the infrared absorption spectrum of the residue. When reaction is complete, the spectrum exhibited typical infrared imide bands at 1701 and 1710 cm-1 whereas if incomplete, the infrared spectrum contains amide and carboxyl absorption bands at 1680, 1760 and 3300 cm-1.
1-(3-Cyanopropyl)-4-(2-pyrimidinyl)-piperazine. A mixture of 1-(2- pyrimidinyl)piperazine (6.0 g, 0.04 mole), 4.6 g (0.044 mole) of 3- chloropropionitrile and sodium carbonate (4.24 g, 0.04 mole) in 50 ml of nbutanol was gently refluxed for 16 hours. The reaction mixture was concentrated in vacuo and the residual oil dissolved in about 100 ml of cyclohexane. On standing a white crystalline material separated which was crystallized from cyclohexane to provide 6.5 g (yield 70%) of the cyano intermediate, m.p. 56.6-58°C. A solution of 11.5 g (0.05 mole) of 1-(3- cyanopropyl)-4-(2-pyrimidinyl)piperazine in 150 ml of absolute ethanol was saturated with ammonia. W-6 Raney nickel catalyst was added and the mixture hydrogenated under 1200 p.s.i. When the hydrogenation was completed the mixture was filtered and the residual oil distilled under reduced pressure to provide 8.2 g (70% ) of 1-(4-aminobutyl)-4-(2- pyrimidinyl)piperazine, b.p. 143-146°C at 0.1 mm. (nD 26 = 1.5582).
The azospiroalkenedione 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8- azaspiro[4.5]decane-7,9-dione was purified as free base by stripping off the pyridine solvent and crystallizing the residue from a suitable solvent or by vacuum distillation thereof hydrochloric salt of it was prepared by treating of an ethanol solution of free base with equimolar amount of HCl.

brand name

Buspar (Bristol-Myers Squibb);BESPAR.

Therapeutic Function

Anxiolytic

Biological Activity

Classic 5-HT 1A partial agonist with relatively high affinity (K i = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Veterinary Drugs and Treatments

Buspirone may be effective in treating certain behavior disorders in dogs and cats, principally those that are fear/phobia related and especially those associated with social interactions. Buspirone may also be useful for urine spraying or treatment of motion sickness in cats.

Buspirone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Buspirone hydrochloride Suppliers

Global( 142)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
13580539051
joe@yuhengpharm.com CHINA 21151 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19233 58

View Lastest Price from Buspirone hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Buspirone hydrochloride
33386-08-2
US $1.00 / kg 1kg 99% Customized career henan chemical co

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