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Bupranolol

CAS No.
14556-46-8
Chemical Name:
Bupranolol
Synonyms
Bupranol;Bupranolol;Ophtorenin;BRN 2272923;Bupranololum;KL 255Ophtorenin;B 1312; BRN 2272923; BUPRANOLOLUM; KL 255OPHTORENIN;1-(tert-Butylamino)-3-[(6-chloro-m-tolyl)oxy]-2-propanol;1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol;(S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol
CBNumber:
CB11118303
Molecular Formula:
C14H22ClNO2
Molecular Weight:
271.78
MDL Number:
MOL File:
14556-46-8.mol
Last updated:2023-09-20 16:43:00

Bupranolol Properties

Melting point 71-74°C
Boiling point 396.3±42.0 °C(Predicted)
Density 1.098±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, Refrigerator, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.82±0.20(Predicted)
color White to Off-White
FDA UNII 858YGI5PIT
ATC code C07AA19

Bupranolol price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B689650 Bupranolol 14556-46-8 500mg $215 2021-12-16 Buy
American Custom Chemicals Corporation INB0000484 BUPRANOLOL 95.00% 14556-46-8 5MG $496.82 2021-12-16 Buy
Medical Isotopes, Inc. 44129 Bupranolol 14556-46-8 5G $2400 2021-12-16 Buy
Product number Packaging Price Buy
B689650 500mg $215 Buy
INB0000484 5MG $496.82 Buy
44129 5G $2400 Buy

Bupranolol Chemical Properties,Uses,Production

Originator

Betadrenol,Pharma-Schwarz,W. Germany,1969

Uses

Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.

Definition

ChEBI: Bupranolol is an aromatic ether.

Manufacturing Process

A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50 ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the residue is washed with water and then extracted with benzene. The dried extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2- propanol. Treatment of the free base in benzene solution with dry hydrogen chloride yields the hydrochloride salt.

Therapeutic Function

Antiarrhythmic

Bupranolol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10269 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
Chengdu Kamel Pharmaceutical Co., Ltd 028-67136579 15828051124 sales@kamelpharm.com China 1751 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3444 55
Beijing OKA biological technology co., LTD 010-62971590 18548936886 3462612863@qq.com China 6912 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55717 58

Bupranolol Spectrum

(2S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol (S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol 1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol 1-(tert-Butylamino)-3-[(6-chloro-m-tolyl)oxy]-2-propanol 1-[(2-Chloro-5-methylphenyl)oxy]-3-[(1,1-dimethylethyl)amino]propan-2-ol Bupranolol 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]- 2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]- (8CI) Bupranol Ophtorenin B 1312; BRN 2272923; BUPRANOLOLUM; KL 255OPHTORENIN BRN 2272923 Bupranololum KL 255Ophtorenin non-selective,competitive,Adrenergic Receptor,Bupranolol,Inhibitor,intrinsic,sympathomimetic,active,Beta Receptor,inhibit,orally 14556-46-8