ChemicalBook
Chinese Japanese Germany Korea

Quinupristin-dalfopristin

Quinupristin-dalfopristin
Quinupristin-dalfopristin structure
CAS No.
126602-89-9
Chemical Name:
Quinupristin-dalfopristin
Synonyms
SYNERCID;Quinupristin-dalfopristin;Mixture with quinupristin;Quinipristine+ Dalfopristin Mesylate;Quinupristin-Dalfopristin Mesylate coMplex;Synercid coMplex, Dalfopristin-Quinupristin coMplex
CBNumber:
CB11252296
Molecular Formula:
C53H67N9O10S.C34H50N4O9S
Formula Weight:
1713.09
MOL File:
126602-89-9.mol

Quinupristin-dalfopristin Chemical Properties,Uses,Production

Description

Dalfopristin and Quinupristin are two well-defined semi-synthetic antibacterials belonging to the class of streptogramins. Together, they form Synercid, an injectable formulation in a ratio 70 : 30 that was launched in the UK followed by the US. The two distinct antibiotic agents, pristinamycins, are bacteriostatic in their own right but, when they are in association, act synergistically at the ribosomal level to inhibit protein synthesis. Synercid is the first antibiotic in its class to reach the market. It appears to be a sound treatment alternative for patients with severe or life-threatening infections, such as the most problematic forms of gram-positive nosocomial sepsis including vancomycin-resistant Enterococcus faecium (VREF) or methicillinresistant Staphylococcus aureus (MRSA).

Originator

Rhone-Poulenc-Rorer (France)

Uses

Quinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as SynercidTM. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.

brand name

Synercid

Quinupristin-dalfopristin Preparation Products And Raw materials

Raw materials

Preparation Products


Quinupristin-dalfopristin Suppliers

Global( 13)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
BOC Sciences
1-631-619-7922 1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19906 58
ChemStrong Scientific Co.,Ltd 15920483169 0755-66853366-
sales@chem-strong.com China 19232 56
ShangHai Biochempartner Co.,Ltd 17754423994 177-54423994-
QQ:2853530910 2853530910@qq.com China 8009 62
Novachemistry +44 (0)208 191 7890
+44 (0)203 637 6965 info@novachemistry.com United Kingdom 3795 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 400-002-6226
sales@biochemall.cn China 54467 58
台州南峰药物研究所 12345678910
nanfengdrug@163 nanfengdrug@163.com China 15328 58
Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
sales@mitachieve.com China 8869 58
Energy Chemical 400-005-6266 021-58432009-
021-58436166 marketing1@energy-chemical.com China 44821 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd qq1701086315 1701086315@qq.com
1701086315@qq.com 1701086315@qq.com China 7617 58
Wuhan Topule 19945035818 027-8721-5551
2936752263@qq.com;2838271459@qq.com China 2998 58
Copyright 2017 © ChemicalBook. All rights reserved