1H-Benzimidazole,5,6-difluoro-(9CI)
- CAS No.
- 78581-99-4
- Chemical Name:
- 1H-Benzimidazole,5,6-difluoro-(9CI)
- Synonyms
- 1H-Benzimidazole,5,6-difluoro-;5,6-difluoro-1H-benzo[d]iMidazole;1H-Benzimidazole,5,6-difluoro-(9CI)
- CBNumber:
- CB11296216
- Molecular Formula:
- C7H4F2N2
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD02031530
- MOL File:
- 78581-99-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5,6-Difluorobenzimidazole | D456233 | 50mg | $65 |
| 5,6-DIFLUOROBENZIMIDAZOLE 95.00% | HCH0013405 | 100MG | $187.95 |
| 5,6-Difluorobenzimidazole | 3H31-3-4M | 250mg | $224 |
| 5,6-Difluorobenzimidazole | PC510221 | 1g | $266 |
| 5,6-Difluorobenzimidazole | 3H31-3-4M | 1g | $426 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933998090 |
1H-Benzimidazole,5,6-difluoro-(9CI) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D456233 | 5,6-Difluorobenzimidazole | 78581-99-4 | 50mg | $65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0013405 | 5,6-DIFLUOROBENZIMIDAZOLE 95.00% | 78581-99-4 | 100MG | $187.95 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H31-3-4M | 5,6-Difluorobenzimidazole | 78581-99-4 | 250mg | $224 | 2021-12-16 | Buy |
| Apolloscientific | PC510221 | 5,6-Difluorobenzimidazole | 78581-99-4 | 1g | $266 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H31-3-4M | 5,6-Difluorobenzimidazole | 78581-99-4 | 1g | $426 | 2021-12-16 | Buy |
1H-Benzimidazole,5,6-difluoro-(9CI) Chemical Properties,Uses,Production
Synthesis
64-18-6
76179-40-3
78581-99-4
The general procedure for the synthesis of 5,6-difluorobenzimidazole from 4,5-difluorophthalimide and formic acid was as follows: 4,5-difluorophthalimide (1.5 g, 10 mmol) was dissolved in formic acid (20 mL) and the reaction was heated for 12 hr at 80 °C. Upon completion of the reaction, the mixture was cooled to 25 °C and subsequently concentrated under reduced pressure to remove the solvent. The resulting residue was purified by recrystallization from a solvent mixture of petroleum ether and ethyl acetate (15:1, v/v) to give the final yellow solid 5,6-difluoro-1H-benzo[d]imidazole (1.4 g, 88% yield). Mass spectrum (ESI) m/z: 155 [M + H]+.
References
[1] Patent: WO2015/100609, 2015, A1. Location in patent: Page/Page column 45
[2] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0756
[3] New Journal of Chemistry, 2006, vol. 30, # 5, p. 803 - 809
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3674 - 3678
[5] ChemCatChem, 2018, vol. 10, # 19, p. 4338 - 4345
1H-Benzimidazole,5,6-difluoro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +8618913958656 | inquiries@moldeep.com | China | 19983 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Henan Rane Chemical Co., Ltd. | +8618738066252 | info@ranechem.com | China | 2999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 | |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16676 | 50 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4987 | 55 |
| Shanghai Boyners Pharm-Tech Co., Ltd. | 13817873692 | mkt@boynerspharm.com | China | 1707 | 55 |
