ChemicalBook >> CAS DataBase List >>9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2

CAS No.
61263-35-2
Chemical Name:
9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2
Synonyms
U 46785;METENPROST;meteneprost;meteneprostum;9-Deoxy-16,16-diMethyl-9-Methylene-PGF2;9-Deoxo-9-Methylene-16,16-diMethyl-PGE2;9-deoxo-16,16-dimethyl-9-methylene-pge2;9-deoxo-16,16-dimethyl-9-methyleneprostaglandine2;9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2;9-Deoxo-16,16-dimethyl-9-methyleneprostaglandine E2
CBNumber:
CB1229488
Molecular Formula:
C23H38O4
Molecular Weight:
378.55
MDL Number:
MFCD01723635
MOL File:
61263-35-2.mol
Last updated:2023-06-08 09:03:09

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Properties

Boiling point 426.61°C (rough estimate)
Density 1.0037 (rough estimate)
refractive index 1.4433 (estimate)
storage temp. Store at -20°C
solubility DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
pka 4.76±0.10(Predicted)
FDA UNII 269EB4R1TV

SAFETY

Risk and Safety Statements

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14420 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 ≥98% 61263-35-2 500μg $51 2024-03-01 Buy
Cayman Chemical 14420 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 ≥98% 61263-35-2 1mg $97 2024-03-01 Buy
Cayman Chemical 14420 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 ≥98% 61263-35-2 5mg $380 2024-03-01 Buy
Cayman Chemical 14420 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 ≥98% 61263-35-2 10mg $657 2024-03-01 Buy
TRC M225570 Meteneprost 61263-35-2 10mg $20350 2021-12-16 Buy
Product number Packaging Price Buy
14420 500μg $51 Buy
14420 1mg $97 Buy
14420 5mg $380 Buy
14420 10mg $657 Buy
M225570 10mg $20350 Buy

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Chemical Properties,Uses,Production

Uses

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; ) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy. Meteneprost, when compared to PGE2 and PGF1α, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.

Uses

Meteneprost is a potent analog of Prostaglandin E2 (PGE2) (P838610). Meteneprost in combination with various other prostaglandin derivatives is used for medical termination of early pregnancy.

Definition

ChEBI: 9-Deoxy-9-methylene-16,16-dimethyl -PGE2 is a long-chain fatty acid.

9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 Preparation Products And Raw materials

Raw materials

Preparation Products

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9-METHYLENE-11ALPHA,15R-DIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 METENPROST 9-Deoxo-9-Methylene-16,16-diMethyl-PGE2 9-Deoxy-16,16-diMethyl-9-Methylene-PGF2 U 46785 5-heptenoicacid,7-(5,5-dimethyl-3-hydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl) 7-(5,5-dimethyl-3-hydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoicaci 9-deoxo-16,16-dimethyl-9-methylene-pge2 9-deoxo-16,16-dimethyl-9-methyleneprostaglandine2 meteneprost meteneprostum (5Z,11α,13E,15S)-11,15-Dihydroxy-16,16-dimethyl-9-methyleneprosta-5,13-dien-1-oic acid (5Z,11α,13E,15S)-16,16-Dimethyl-9-methylene-11,15-dihydroxyprosta-5,13-dien-1-oic acid (5Z,11α,13E,15S)-16,16-Dimethyl-9-methylene-11,15-dihydroxyprosta-5,13-diene-1-oic acid 9-Deoxo-16,16-dimethyl-9-methyleneprostaglandine E2 (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-diMethyl-9-Methyleneprosta-5,13-dien-1-oic Acid Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dimethyl-9-methylene-, (5Z,11α,13E,15R)- 9-DEOXY-9-METHYLENE-16,16-DIMETHYL PROSTAGLANDIN E2 USP/EP/BP 61263-35-2 61263-35-3 Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals