4'-Trifluoromethylbiphenyl-4-carboxylic acid
- CAS No.
- 195457-71-7
- Chemical Name:
- 4'-Trifluoromethylbiphenyl-4-carboxylic acid
- Synonyms
- 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid;AKOS BAR-0023;RARECHEM AL BE 1218;4-CARBOXY-4'-TRIFLUOROMETHYLDIPHENYL;4-[4-(trifluoromethyl)phenyl]benzoate;4-(4-(Trifluoromethyl)phenyl)benzoic acid;4'-Trifluoromethylbiphenyl-4-carboxylic acid;4''-TRIFLUOROMETHYL-BIPHENYL-4-CARBOXYLIC ACID, 95+%;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;[1,1'-Biphenyl]-4-carboxylic acid, 4'-(trifluoroMethyl)-
- CBNumber:
- CB1237609
- Molecular Formula:
- C14H9F3O2
- Molecular Weight:
- 266.22
- MDL Number:
- MFCD03424606
- MOL File:
- 195457-71-7.mol
- MSDS File:
- SDS
| Melting point | 120.0-121.1 °C |
|---|---|
| Boiling point | 360.8±42.0 °C(Predicted) |
| Density | 1.326±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.04±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 195457-71-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Hazard Note | Irritant |
| HS Code | 2916399090 |
4'-Trifluoromethylbiphenyl-4-carboxylic acid price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FT33145 | 4'-Trifluoromethyl-biphenyl-4-carboxylic acid | 195457-71-7 | 1000mg | $180 | 2026-06-04 | Buy |
| Biosynth | FT33145 | 4'-Trifluoromethyl-biphenyl-4-carboxylic acid | 195457-71-7 | 2000mg | $300 | 2026-06-04 | Buy |
| Biosynth | FT33145 | 4'-Trifluoromethyl-biphenyl-4-carboxylic acid | 195457-71-7 | 5000mg | $700 | 2026-06-04 | Buy |
| Biosynth | FT33145 | 4'-Trifluoromethyl-biphenyl-4-carboxylic acid | 195457-71-7 | 10000mg | $1200 | 2026-06-04 | Buy |
| Apolloscientific | PC11180 | 4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid 98% | 195457-71-7 | 1g | $73 | 2026-06-04 | Buy |
4'-Trifluoromethylbiphenyl-4-carboxylic acid Chemical Properties, Uses, Production
Uses
4''-(Trifluoromethyl)[1,1''-biphenyl]-4-carboxylic Acid is a reagent used in the synthesis of pharmaceuticals and pharmaceutical intermediates
Synthesis
586-76-5
128796-39-4
195457-71-7
The general procedure for the synthesis of 4'-trifluoromethyl-diphenyl-4-carboxylic acid from 4-bromobenzoic acid and 4-trifluoromethylphenylboronic acid was as follows: the reaction was carried out according to General Method D. 4-Bromobenzoic acid (10 g, 49.4 mmol), 4-trifluoromethylphenylboronic acid (14.17 g, 74.61 mmol), tetrakis(triphenylphosphine)palladium (5.7 g, 4.974 mmol) and 2N Na2CO3 aqueous solution (150 mL, 149.2 mmol) were mixed in 500 mL of toluene. Upon completion of the reaction, the reaction mixture was neutralized with 2N HCl and subsequently filtered. The resulting solid was dissolved in ethyl acetate and purified by a short silica gel column to give 9.7 g (75% yield) of the target product 4'-trifluoromethyl-diphenyl-4-carboxylic acid as a white solid.
References
[1] Tetrahedron Letters, 2005, vol. 46, # 34, p. 5751 - 5754
[2] Green Chemistry, 2010, vol. 12, # 1, p. 150 - 158
[3] Patent: WO2004/14844, 2004, A2. Location in patent: Page 179; 181
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 20, p. 4939 - 4952
[5] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3144 - 3150
4'-Trifluoromethylbiphenyl-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 | |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4989 | 50 |
| Shanghai GaoDao Pharmaceutical Co., Ltd. | 021-15001867143 15001867143 | 1095570358@qq.com | China | 914 | 55 |
View Latest Price from 4'-Trifluoromethylbiphenyl-4-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-13 | 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4"-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID
195457-71-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
