ChemicalBook >> CAS DataBase List >>B-Raf inhibitor 1
B-Raf inhibitor 1
- CAS No.
- 1093100-40-3
- Chemical Name:
- B-Raf inhibitor 1
- Synonyms
- CS-927;or Base;B-RAFcas;Raf inhibitor 1;B-Raf inhibitor 1;BRAF inhibitor 13;B-Raf inhibitor 1 Base;B-Raf inhibitor 1, >=98%;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine;N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
- CBNumber:
- CB12652787
- Molecular Formula:
- C26H19ClN8
- Molecular Weight:
- 478.94
- MDL Number:
- MFCD22571725
- MOL File:
- 1093100-40-3.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
B-Raf inhibitor 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | BISN0223 | B-Raf inhibitor 1 | 1093100-40-3 | 1mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | B1172 | B-Rafinhibitor1 | 1093100-40-3 | 5mg | $105 | 2021-12-16 | Buy |
| ChemScene | CS-2182 | Rafinhibitor1 98.05% | 1093100-40-3 | 5mg | $120 | 2021-12-16 | Buy |
| Apolloscientific | BISN0223 | B-Raf inhibitor 1 | 1093100-40-3 | 5mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-2182 | Rafinhibitor1 98.05% | 1093100-40-3 | 10mg | $180 | 2021-12-16 | Buy |
B-Raf inhibitor 1 Chemical Properties,Uses,Production
Biological Activity
B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively.
in vitro
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.
target
| B-Raf < span> 1 nM (Ki) | B-Raf V600E 1 nM (Ki) | c-Raf 0.3 nM (Ki ) |
B-Raf inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 67)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
1093100-40-3(B-Raf inhibitor 1)Related Search:
B-Raf inhibitor 1
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine
B-Raf inhibitor 1, >=98%
B-RAFcas
Raf inhibitor 1
1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine
or Base
B-Raf inhibitor 1 Base
CS-927
BRAF inhibitor 13
N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
1093100-40-3
C26H19ClN8
Inhibitors