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5-IODOTUBERCIDIN

5-IODOTUBERCIDIN Structure
5-IODOTUBERCIDIN structure
CAS No.
24386-93-4
Chemical Name:
5-IODOTUBERCIDIN
Synonyms
ITU;5-ITu;CS-824;NSC 113939;IODOTUBERCIDIN;7-I-7-Deaza-Ar;5-IODOTUBERCIDIN;5-IODOTUBERICIDIN;Iodotubercidin,Itu;5-Iodo-Tubercidine
CBNumber:
CB1280221
Molecular Formula:
C11H13IN4O4
Molecular Weight:
392.15
MDL Number:
MFCD00055131
MOL File:
24386-93-4.mol
Last updated:2023-06-30 15:45:59
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5-IODOTUBERCIDIN Properties

Melting point 216-217°C dec.
Boiling point 701.5±60.0 °C(Predicted)
Density 2.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility 0.1 M HCl: 0.7 mg/mL
form solid
pka 12.33±0.70(Predicted)
color tan
Stability Store tightly sealed at 4°C; Light Sensitive
InChIKey WHSIXKUPQCKWBY-IOSLPCCCSA-N
CAS DataBase Reference 24386-93-4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
WGK Germany  3
HS Code  29349990

5-IODOTUBERCIDIN price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I100 5-Iodotubericidin ≥90%, solid 24386-93-4 5mg $683 2024-03-01 Buy
Sigma-Aldrich I100 5-Iodotubericidin ≥90%, solid 24386-93-4 25mg $2670 2024-03-01 Buy
Cayman Chemical 10010375 5-Iodotubercidin ≥95% 24386-93-4 500 μg $56 2024-03-01 Buy
Cayman Chemical 10010375 5-Iodotubercidin ≥95% 24386-93-4 100μg $15 2022-04-27 Buy
Cayman Chemical 10010375 5-Iodotubercidin ≥95% 24386-93-4 250μg $32 2022-04-27 Buy
Product number Packaging Price Buy
I100 5mg $683 Buy
I100 25mg $2670 Buy
10010375 500 μg $56 Buy
10010375 100μg $15 Buy
10010375 250μg $32 Buy

5-IODOTUBERCIDIN Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

A potent and competitive inhibitor of ERK2, PKA, and ADK.

Uses

5-Iodotubercidin has been used for the inhibition of retinoblastoma cells, astroglial cultures and for the inhibition of adenosine kinase in human umbilical vein endothelial cells (HUVECs).

Uses

An analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic. A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into brain slices.

General Description

solubility: 10 mg/mL in DMSO

Biological Activity

Potent adenosine kinase inhibitor (IC 50 = 26 nM) and nucleoside transporter inhibitor (IC 50 values are 7, 15 and < 25 nM for inhibition of [ 3 H]-uridine, [ 3 H]-formycin B and [ 3 H]-adenosine uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC 50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μ M respectively).

Biochem/physiol Actions

Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.

storage

Store at -20°C

References

[1]. xin zhang, deyong jia, huijuan liu, et al. identification of 5-iodotubercidin as a genotoxic drug with anti-cancer potential. plos one, 2013, 8(5):e62527.
[2]. jaoek park and radhey s. gupta. adenosine: a key link between metabolism and brain activity: adenosine metabolism, adenosine kinase, and evolution. new york: springer science+business media, 2013.
[3]. garcía-villafranca j. and castro j. effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-coa carboxylase. biochem. pharmacol., 2002, 63(11):1997-2000.
[4]. haiyan chen, ji-ping wang, richard j. santen, et al. adenosine monophosphate activated protein kinase (ampk), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. apoptosis, 2015, 20:821-830.

5-IODOTUBERCIDIN synthesis

3680-69-1
24386-93-4
Synthesis of 5-IODOTUBERCIDIN from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

5-IODOTUBERCIDIN Preparation Products And Raw materials

Raw materials

α-D-Ribofuranosyl chloride, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)- 7H-Pyrrolo[2,3-d]pyrimidine,4-chloro-5-iodo-7-b-D-ribofuranosyl- 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine 5-O-TERT-BUTYLDIMETHYLSILYL-2,3-O-ISOPROPYLIDENE-D-RIBOFURANOSE 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-5-iodo-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-
TUBERCIDIN 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

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Preparation Products

5-IODOTUBERCIDIN Suppliers

Global( 171)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Beijing Ribio Biotech Co.,Ltd 		010-62664360 +8613328773880 wucy@ribio.com.cn China 117 58
Yunbio Tech Co.,Ltd. 		+86-010-60605551 +86-18046518538 yunbiochem@126.com China 321 58
Nanjing Baifuli Technology Co., Ltd. 		+86-15335185688 sales@unisyn.cn CHINA 332 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Boc Chemical Co., Ltd. 		021-34975602; +8618721111801 shangli@bocchem.com China 138 58
Supplier Advantage
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58
Biochempartner 		58
Beijing Ribio Biotech Co.,Ltd 		58
Yunbio Tech Co.,Ltd. 		58
Nanjing Baifuli Technology Co., Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Boc Chemical Co., Ltd. 		58

View Lastest Price from 5-IODOTUBERCIDIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-IODOTUBERCIDIN pictures 2024-02-06 5-IODOTUBERCIDIN
24386-93-4
 US $1.00 / KG 1KG 97% 200 Yunbio Tech Co.,Ltd.
5-Iodotubercidin pictures 2021-09-29 5-Iodotubercidin
24386-93-4
 US $0.00-0.00 / g 1g 97%min 1000g WUHAN FORTUNA CHEMICAL CO., LTD
5-IODOTUBERCIDIN pictures 2019-08-06 5-IODOTUBERCIDIN
24386-93-4
 US $5.00 / KG 1KG 99% 1ton Career Henan Chemical Co
  • 5-Iodotubercidin pictures
  • 5-Iodotubercidin
    24386-93-4
  • US $0.00-0.00 / g
  • 97%min
  • WUHAN FORTUNA CHEMICAL CO., LTD

5-IODOTUBERCIDIN Spectrum

5-IODOTUBERCIDIN(24386-93-4)1HNMR

24386-93-4(5-IODOTUBERCIDIN)Related Search:

PIERICIDIN A IODOTUBERCIDIN FROM RAT OR GUINEA PI 7-iodotubercidin 5'-deoxy-5-iodotubercidin 4-Amino-7H-pyrrolo[2,3-d]pyrimidine
TUBERCIDIN DEAZAPURINE 7-DEAZA-2'-DEOXYADENOSINE 1-(2-HYDROXYETHYL)PYRROLE 1-(3-HYDROXYPROPYL)PYRROLE
5-IODOTUBERCIDIN

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7-IODO-7-DEAZAADENOSINE 5-IODOTUBERCIDIN 5-IODOTUBERICIDIN 4-AMINO-5-IODO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE IODOTUBERCIDIN ITU Iodotubercidin,Itu 4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 4-amino-5-iodo-7-(β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 5-IODOTUBERCIDIN 98+% iodotubercidin, 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7-Deaza-7-iodoadenosine 5-Iodotubercidin (or 7-Deaza-7-iodoadenosine) 3-d]pyriMidin-7-yl)-tetrahydro-5-(hydroxyMethyl)furan-3 5R)-2-(4-aMino-5-iodo-7H-pyrrolo[2 NSC 113939 5-ITu 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine,5-iodo-7-b-D-ribofuranosyl- 7-Iodo-7-deazaadenosine, 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (2R,3R,4S,5R)-2-(4-amino-5-iodo-5H-pyrrolo[2,3-d]pyrimidin-7(6H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 7-I-7-Deaza-Ar (2S,3S,4R,5S)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 5-IODOTUBERCIDIN USP/EP/BP 4-Amino-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, 7-Iodo-tubercidin, 7-deaza-7-iodoadenosine 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-iodo-7-β-D-ribofuranosyl- 5-Iodotubercidin (NSC 113939) 2-{4-AMINO-5-IODOPYRROLO[2,3-D]PYRIMIDIN-7-YL}-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL CS-824 5-Iodo-Tubercidine 3-d]pyrimidin-4- amine 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2 4-Amino-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine 7-Iodo-tubercidin,7-Deaza-7-iodoadenosine,Adenosine kinase inhibitor, Protein kinase inhibitor and activator, nucleoside transporters inhibitor 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 24386-93-4 C11H13IN4O4 Bases & Related Reagents Inhibitors Nucleotides Protein Kinase Inhibitors and Activators Miscellaneous Natural Products