5-IODOTUBERCIDIN
- CAS No.
- 24386-93-4
- Chemical Name:
- 5-IODOTUBERCIDIN
- Synonyms
- ITU;5-ITu;CS-824;NSC 113939;IODOTUBERCIDIN;7-I-7-Deaza-Ar;5-IODOTUBERCIDIN;5-IODOTUBERICIDIN;Iodotubercidin,Itu;5-Iodo-Tubercidine
- CBNumber:
- CB1280221
- Molecular Formula:
- C11H13IN4O4
- Molecular Weight:
- 392.15
- MDL Number:
- MFCD00055131
- MOL File:
- 24386-93-4.mol
Melting point | 216-217°C dec. |
---|---|
Boiling point | 701.5±60.0 °C(Predicted) |
Density | 2.49±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | 0.1 M HCl: 0.7 mg/mL |
form | solid |
pka | 12.33±0.70(Predicted) |
color | tan |
Stability | Store tightly sealed at 4°C; Light Sensitive |
InChIKey | WHSIXKUPQCKWBY-IOSLPCCCSA-N |
CAS DataBase Reference | 24386-93-4 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
WGK Germany | 3 |
HS Code | 29349990 |
5-IODOTUBERCIDIN price More Price(55)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I100 | 5-Iodotubericidin ≥90%, solid | 24386-93-4 | 5mg | $683 | 2024-03-01 | Buy |
Sigma-Aldrich | I100 | 5-Iodotubericidin ≥90%, solid | 24386-93-4 | 25mg | $2670 | 2024-03-01 | Buy |
Cayman Chemical | 10010375 | 5-Iodotubercidin ≥95% | 24386-93-4 | 500 μg | $56 | 2024-03-01 | Buy |
Cayman Chemical | 10010375 | 5-Iodotubercidin ≥95% | 24386-93-4 | 100μg | $15 | 2022-04-27 | Buy |
Cayman Chemical | 10010375 | 5-Iodotubercidin ≥95% | 24386-93-4 | 250μg | $32 | 2022-04-27 | Buy |
5-IODOTUBERCIDIN Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
Uses
A potent and competitive inhibitor of ERK2, PKA, and ADK.
Uses
5-Iodotubercidin has been used for the inhibition of retinoblastoma cells, astroglial cultures and for the inhibition of adenosine kinase in human umbilical vein endothelial cells (HUVECs).
Uses
An analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic. A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into brain slices.
General Description
solubility: 10 mg/mL in DMSO
Biological Activity
Potent adenosine kinase inhibitor (IC 50 = 26 nM) and nucleoside transporter inhibitor (IC 50 values are 7, 15 and < 25 nM for inhibition of [ 3 H]-uridine, [ 3 H]-formycin B and [ 3 H]-adenosine uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC 50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μ M respectively).
Biochem/physiol Actions
Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.
storage
Store at -20°C
References
[1]. xin zhang, deyong jia, huijuan liu, et al. identification of 5-iodotubercidin as a genotoxic drug with anti-cancer potential. plos one, 2013, 8(5):e62527.
[2]. jaoek park and radhey s. gupta. adenosine: a key link between metabolism and brain activity: adenosine metabolism, adenosine kinase, and evolution. new york: springer science+business media, 2013.
[3]. garcía-villafranca j. and castro j. effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-coa carboxylase. biochem. pharmacol., 2002, 63(11):1997-2000.
[4]. haiyan chen, ji-ping wang, richard j. santen, et al. adenosine monophosphate activated protein kinase (ampk), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. apoptosis, 2015, 20:821-830.
5-IODOTUBERCIDIN Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Beijing Ribio Biotech Co.,Ltd | 010-62664360 +8613328773880 | wucy@ribio.com.cn | China | 117 | 58 |
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 | shangli@bocchem.com | China | 138 | 58 |
View Lastest Price from 5-IODOTUBERCIDIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | 5-Iodotubercidin
24386-93-4
|
US $0.00-0.00 / g | 1g | 97%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-07 | 5-IODOTUBERCIDIN
24386-93-4
|
US $1.00 / KG | 1KG | 97% | 200 | Yunbio Tech Co.,Ltd. | ||
2019-08-06 | 5-IODOTUBERCIDIN
24386-93-4
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
- 5-Iodotubercidin
24386-93-4
- US $0.00-0.00 / g
- 97%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- 5-IODOTUBERCIDIN
24386-93-4
- US $1.00 / KG
- 97%
- Yunbio Tech Co.,Ltd.
- 5-IODOTUBERCIDIN
24386-93-4
- US $5.00 / KG
- 99%
- Career Henan Chemical Co