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Amylamine

CAS No.
110-58-7
Chemical Name:
Amylamine
Synonyms
PENTYLAMINE;N-PENTYLAMINE;1-Pentanamine;Pentylamin;1-PENTYLAMINE;Amylamin;AMINE C5;AMYLAMINE;n-C5H11NH2;AMYLAMINES
CBNumber:
CB1420771
Molecular Formula:
C5H13N
Molecular Weight:
87.16
MDL Number:
MFCD00008236
MOL File:
110-58-7.mol
MSDS File:
SDS
Modify Date:
2022-08-15 17:36:37

Amylamine Properties

Melting point −55 °C(lit.)
Boiling point 104 °C(lit.)
Density 0.752 g/mL at 25 °C(lit.)
vapor density 3.01 (vs air)
vapor pressure 120.9 hPa (47 °C)
FEMA 4242 | PENTYLAMINE
refractive index n20/D 1.411(lit.)
Flash point 42 °F
storage temp. Flammables area
solubility Soluble in alcohol, ether.
pka 10.63(at 25℃)
form Liquid
color Clear colorless to very slightly yellow
explosive limit 2.2-22%(V)
Water Solubility soluble
Sensitive Air Sensitive
Merck 14,598
JECFA Number 1585
BRN 505953
CAS DataBase Reference 110-58-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) PENTYLAMINE
EWG's Food Scores 2
FDA UNII E05QM3V8EF
NIST Chemistry Reference 1-Pentanamine(110-58-7)
EPA Substance Registry System Amylamine (110-58-7)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H225-H302+H312-H314-H331-H412
Precautionary statements  P210-P261-P273-P280-P305+P351+P338-P310
Hazard Codes  F,C
Risk Statements  11-22-34-42/43-20/21/22-52/53
Safety Statements  16-26-36/37/39-45-33-61
RIDADR  UN 1106 3/PG 2
WGK Germany  3
RTECS  SC0300000
34
Autoignition Temperature 305 °C
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29211990
Toxicity LD50 orally in Rabbit: 470 mg/kg LD50 dermal Rabbit 1120 mg/kg
NFPA 704
3
3 0

Amylamine price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 171409 Amylamine 99% 110-58-7 25ml $53.2 2022-05-15 Buy
Sigma-Aldrich 171409 Amylamine 99% 110-58-7 50ml $90.5 2022-05-15 Buy
TCI Chemical A0445 Amylamine >98.0%(GC) 110-58-7 25mL $36 2022-04-27 Buy
TCI Chemical A0445 Amylamine >98.0%(GC) 110-58-7 100mL $109 2022-04-27 Buy
Alfa Aesar A11674 1-Pentylamine, 98% 110-58-7 25g $44.5 2022-04-27 Buy
Product number Packaging Price Buy
171409 25ml $53.2 Buy
171409 50ml $90.5 Buy
A0445 25mL $36 Buy
A0445 100mL $109 Buy
A11674 25g $44.5 Buy

Amylamine Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid; fishy aroma.

Chemical Properties

clear colourless to very slightly yellow liquid

Chemical Properties

n-Amylamine is a strong base in aqueous solutions and organic solvents that readily forms salts with acids.

Uses

Chemical intermediate, dyestuffs, rubber chemicals, insecticides, synthetic detergents, flotation agents, corrosion inhibitors, solvent, gasoline additive, pharmaceuticals.

Uses

1-Pentylamine is a useful reactant in organic synthesis.

Uses

Amylamine is a general reagent used in functionalizing the target molecules with pentyl chain. It has also been used as a cosurfactant to increase the phase stability of the bilayer systems.

Production Methods

n-Amylamine is primarily produced by the amination of alkyl halides rather than using alcohol. This reaction is carried out at a temperature of 300-500°C and a pressure of 790-3550 kPa. Alternatively, n-amylamine can be produced from the reaction of amyl chlorides with ammonia. This procedure also produces small amounts of amylenes and amyl alcohol which can be removed by steam distillation (Schweizer et al 1978).

Aroma threshold values

High strength odor; fishy type; recommend smelling in a 0.10% solution or less.

General Description

A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Irritates the eyes and respiratory system. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a corrosion inhibitor, solvent, flotation agent and in the manufacture of other chemicals.

Air & Water Reactions

Highly flammable. Less dense than water and soluble in water.

Reactivity Profile

AMYLAMINES are amines. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Can react with oxidizing materials. [NTP 1992].

Hazard

Flammable, dangerous fire risk. Strong irritant.

Health Hazard

Direct skin contact with amylamine leads to first- and second-degree burns. Inhalation results in irritation of the mucous membranes of the nose and respiratory tract. It has been reported that in humans a concentration of 0.3 mg/1 of the inhaled n-amylamine had no irritating effect (Loit and Filou 1964).

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Industrial uses

In 1976, 800 tons of n-amylamine was produced for a variety of commercial purposes. It is used in textiles, lubrication and in the manufacture of dyestuffs, emulsifying agents, anti-oxidants and desizing agents for the textile and pharmaceutical industry. It is also valuable as a corrosion inhibitor and as a base for emulsifiers which are soluble in vegetable and mineral oils.

Safety Profile

Poison by intraperitoneal route. A corrosive. A flammable liquid. When heated to decomposition it emits toxic vapors of NOx.

Metabolism

As exposure to n-amylamine is often via inhalation, several studies have investigated the uptake and distribution of amylamine by lungs. For a number of aliphatic amines their uptake correlated well with their partition coefficients (between n-octanol and pH 7 buffer) (Fowler et al 1976). The amino group, as well as the relatively lipophilic alkyl group, was required for lung specificity. It was also demonstrated using inhibitors that n-amylamine was rapidly metabolized to CO2 by monoamine oxidase and that CO2 exhalation increased with increasing chain length from C4 to C13. Another study on the pharmacokinetics of n-amylamine uptake by lung demonstrated that the distribution of n-amylamine between vascular and extravascular spaces was sensitive to arterial pH, with alkalosis favoring extravascular distribution (Effros and Chihard 1969).
The ability of n-amylamine to serve as a substrate or an inhibitor of monoamine oxidase has been addressed in a number of in vitro and in vivo studies. However, many of the results are contradictory and appear to be related to concentrationdependent phenomena. When tested in vitro, n-amylamine was reported to inhibit rat liver monoamine oxidase in a partially irreversible and noncompetitive manner (Takagi and Gomi 1966). Longer chain aliphatic amines were even more inhibitory. In contrast, at lower concentrations n-amylamine served as a substrate for monoamine oxidase. Weiner (1966) also concluded that n-amylamine was a poor substrate for monoamine oxidase isolated from rat, mouse, dog, cat, and human brains. The amine was more active towards rabbit brain monoamine oxidase. When administered intraperitoneally to rats, n-amylamine had no effect on liver monoamine oxidase activity (Valiev 1974).
Several other studies strongly suggest that amylamine is a substrate for monoamine oxidase and is metabolized by this enzyme in vivo. McEwen (1965a) purified monoamine oxidase from human plasma and found it to be most active against several simple aliphatic amines, with butylamine being the most active substrate. Further characterization indicated that high concentrations of the amine inhibited the enzyme and that the non-ionized forms of the amines are responsible for the observed competitive inhibition (McEwen 1965b). In agreement, others reported that n-amylamine was a good substrate for monoamine oxidase purified from dog serum (Ikeno et al 1978). In another in vitro study, Kurosawa (1974) demonstrated n-amylamine to be a substrate for monoamine oxidase prepared from beef or rat liver. In vivo, it was found that, in rats, the release of 14CO2 from 14C-amylamine was significantly decreased by riboflavin or iron deficiency, conditions which also decreased monoamine oxidase activity (Sourkes and Missala 1976). These studies all indicate that amylamine is metabolized by monoamine oxidase in a variety of species.

Purification Methods

Dry it by prolonged shaking with NaOH pellets, then distilling. Store it in a CO2-free atmosphere. [Beilstein 4 IV 674.]

Amylamine Preparation Products And Raw materials

Global( 227)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418679 info@tnjchem.com China 2995 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
592-6051114 sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 23034 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14344 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695 info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47501 58
career henan chemical co
+86-0371-86658258 factory@coreychem.com China 29862 58
SIMAGCHEM CORP
+86-13806087780 +86-13806087780 sale@simagchem.com China 17384 58

View Lastest Price from Amylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-05-20 Amylamine
110-58-7
US $1.50 / g 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
2021-07-02 1-Pentylamine, 1-Aminopentane, n-Amylamine, н-пропиловый спирт
110-58-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2020-01-13 Amylamine
110-58-7
US $1.00 / g 1g 99% 10000KGS Career Henan Chemical Co
  • Amylamine
    110-58-7
  • US $1.50 / g
  • 99.0% Min
  • Shaanxi Didu New Materials Co. Ltd
  • Amylamine
    110-58-7
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co
PentylaMiMe n-Amylamine,99% n-Amylamine,97% Amylamine, n-: (1-Pentylamine) Pentylamine, 98+% n-Pentylamine, 98+% 1-Aminopentane, n-Amylamine 1-Aminopentane, n-Amylamine, Pentylamine Amylamines, mixture of isomers N-PENTYLAMINE FOR SYNTHESIS 25 ML N-PENTYLAMINE FOR SYNTHESIS 100 ML 1-Aminopentane Pentylamine 1-Aminopentane, Amylamine Amylamines, mixture of isomers >=98% n-Pentylamine for synthesis RARECHEM AL BW 0079 N-AMYLAMINE MONOAMYLAMINE 1-Aminopentan 1-Pentylamin Amylamin amylamine2,4-dichlorophenoxyacetate Monopentylamine n-C5H11NH2 Norleucamine n-Pentylamin AMINE C5 AMYLAMINE AMYLAMINES 1-AMYLAMINE 1-AMINOPENTANE 1-Aminopentylane n-Amylamine;n-Pentylamine Amylamine mixed isomers AMYLAMINES, 98+%, MIXTURE OF ISOMERS Pentylamine, mono- PENTYLAMIN-N н-пропиловый спирт, 1-Pentylamine, 1-Aminopentane, n-Amylamine Diquafosol Impurity 18 Diquafosol Impurity 9 Amylamine > Amylamine, 98%+ AMYLAMINE For Synthesis PENTYLAMINE N-PENTYLAMINE 1-Pentanamine 1-PENTYLAMINE Pentylamin 110-58-7 CH3CH24NH2 CH3CH23CH2NH2 C5H11NH2 110587 AMINE Organic Building Blocks Nitrogen Compounds Monofunctional & 伪,蠅-Bifunctional Alkanes Alkylamines