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Valeronitrile

Valeronitrile
Valeronitrile structure
CAS No.
110-59-8
Chemical Name:
Valeronitrile
Synonyms
NITRILE C5;1-Cyanbutan;Butylcyanid;CH3(CH2)3CN;PENTANITRILE;Valeronitril;BUTYL CYANIDE;VALERONITRILE;1-Cyanobutane;PENTANONITRILE
CBNumber:
CB2250133
Molecular Formula:
C5H9N
Formula Weight:
83.13
MOL File:
110-59-8.mol

Valeronitrile Properties

Melting point:
−96 °C(lit.)
Boiling point:
139-141 °C(lit.)
Density 
0.795 g/mL at 25 °C(lit.)
vapor pressure 
7.0 hPa (20 °C)
refractive index 
n20/D 1.397(lit.)
Flash point:
105 °F
storage temp. 
Store below +30°C.
solubility 
10.0g/l
form 
Liquid
color 
Clear colorless
Water Solubility 
0.1-0.5 g/100 mL at 22.5 ºC
Merck 
14,9905
BRN 
1736706
Stability:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Flammable.
InChIKey
RFFFKMOABOFIDF-UHFFFAOYSA-N
CAS DataBase Reference
110-59-8(CAS DataBase Reference)
NIST Chemistry Reference
Pentanenitrile(110-59-8)
EPA Substance Registry System
Pentanenitrile(110-59-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  10-25-2017/10/25
Safety Statements  36/37/39-45-16
RIDADR  UN 1992 3/PG 3
WGK Germany  3
RTECS  YV8195000
Autoignition Temperature 520 °C
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29269095
HS Code  29332100
Toxicity LD50 orally in male mice: 2.297 mmol/kg (Tanii)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Valeronitrile price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 155098 Valeronitrile 99.5% 110-59-8 100g $61.1 2018-11-13 Buy
Sigma-Aldrich 8.08514 Pentanonitrile for synthesis. CAS 110-59-8, EC Number 203-781-8, chemical formula CH (CH ) CN., for synthesis 110-59-8 8085140100 $71 2018-11-23 Buy
TCI Chemical V0008 Valeronitrile >98.0%(GC) 110-59-8 25mL $23 2018-11-22 Buy
TCI Chemical V0008 Valeronitrile >98.0%(GC) 110-59-8 500mL $188 2018-11-22 Buy
Alfa Aesar A10306 Valeronitrile, 99% 110-59-8 100ml $58.2 2018-11-13 Buy

Valeronitrile Chemical Properties,Uses,Production

Chemical Properties

Clear liquid

Uses

Valeronitrile is used as building block in organic synthesis. Product Data Sheet

Uses

Solvent.

Production Methods

Valeronitrile can be synthesized by dehydration of valeronamide. The nitrile is also found in nature and is a constituent of coal gasification and oil shale processing waste water, sewage wastewater and tobacco smoke.

General Description

Clear colorless to yellow liquid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Nitriles, such as Valeronitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Valeronitrile is incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. .

Health Hazard

Valeronitrile is an irritant and may be harmful by inhalation, ingestion or skin absorption .

Fire Hazard

Valeronitrile is combustible.

Industrial uses

Valeronitrile is used as an industrial solvent and as a chemical intermediate.

Metabolism

As with other aliphatic nitriles, valeronitrile is metabolized in vivo resulting in the liberation of cyanide ion which is responsible for much of the observed toxicity of this compound . Biotransformation of valeronitrile presumably proceeds in a manner similar to that of other aliphatic nitriles with an initial cytochrome P-450 catalyzed oxidation of the nitrile to the cyanohydrin followed by release of the cyanide group from the activated molecule. Cyanide formation was significantly reduced when valeronitrile was incubated with mouse hepatic microsomes in the presence of SKF-525A or carbon monoxide or when microsomes from mice pretreated with chloroform were used . Ethanol pretreatment of mice markedly increases the in vivo and in vitro microsomal oxidation of valeronitrile presumably as a result of increased levels of an ethanol inducible cytochrome P-450 . As with other nitriles, the cyanide released upon biotransformation of valeronitrile is readily converted to thiocyanate in vivo and the latter ion was the major urinary excretion product observed with valero-nitrile in rats . From 18 to 31% of a daily 175 mg/kg dose of valeronitrile was eliminated in the urine as thiocyanate during a 24 h period. In another study , 43.2 and 27.5%, respectively, of an oral or i.p. dose of 0.75 mmol/kg valeronitrile was excreted as thiocyanate in the urine of male Sprague-Dawley rats over a 24 h period.

Purification Methods

Wash the nitrile with half its volume of conc HCl (twice), then with saturated aqueous NaHCO3, dry it with MgSO4 and fractionally distil it from P2O5. [Beilstein 2 H 301, 2 I 131, 2 II 267, 2 III 675, 2 IV 875.]

Valeronitrile Preparation Products And Raw materials

Raw materials

Preparation Products


Valeronitrile Suppliers

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Valeronitrile Spectrum


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