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STERIGMATOCYSTIN

STERIGMATOCYSTIN
STERIGMATOCYSTIN structure
CAS No.
10048-13-2
Chemical Name:
STERIGMATOCYSTIN
Synonyms
NSC 204985;NSC 201423;,(3ar-cis)-;STERIGMATOCYSTIN;STERIGMATOCYSTINE;Sterigmatocystin,98%;Sterigmatocystin solution ;STERIGMATOCYSTIN VIAL WITH 5 MG*;STERIGMATOCYSTIN, ASPERGILLUS VERSICOLOR;SterigMatocystin froM Aspergillus Versicolor
CBNumber:
CB1475014
Molecular Formula:
C18H12O6
Formula Weight:
324.28
MOL File:
10048-13-2.mol

STERIGMATOCYSTIN Properties

Melting point:
249-251℃
Boiling point:
382.63°C (rough estimate)
Density 
1.2842 (rough estimate)
refractive index 
1.4800 (estimate)
Flash point:
6℃
storage temp. 
2-8°C
form 
powder
color 
yellow
BRN 
53259
CAS DataBase Reference
10048-13-2
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xn,F
Risk Statements  25-40-36-20/21/22-11
Safety Statements  36/37-45-16
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  LV1750000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

STERIGMATOCYSTIN price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32986 Sterigmatocystin solution 50μg/mL in acetonitrile, analytical standard 10048-13-2 1ml $300 2018-11-20 Buy
Sigma-Aldrich 32609 Sterigmatocystin reference material 10048-13-2 5mg $932 2018-11-20 Buy
Cayman Chemical 11441 Sterigmatocystin ≥98% 10048-13-2 500μg $25 2018-11-19 Buy
Cayman Chemical 11441 Sterigmatocystin ≥98% 10048-13-2 1mg $40 2018-11-19 Buy
Sigma-Aldrich S3255 Sterigmatocystin powder, ≥98% (TLC) 10048-13-2 1mg $59.2 2018-11-20 Buy

STERIGMATOCYSTIN Chemical Properties,Uses,Production

Chemical Properties

yellow needles or powder

Uses

Sterigmatocystin is a carcinogenic mycotoxin that is struturally related to Aflatoxin. Sterigmatocystin has been shown to inhibit RNA synthesis in rat liver nuclei.

Uses

Sterigmatocystin is a xanthone produced by several species of Aspergillus, isolated by a number of research groups in the 1950s as a mycotoxin associated with food and grain contamination. Sterigmatocystin is structurally related to the aflatoxins and, while it is considered to be mutagenic, teratogenic and carcinogenic, it is less widespread and potent than the aflatoxins. Sterigmatocystin, in the presence of microsomes, covalently binds to DNA. It uncouples oxidative phosphorylation but, unlike the aflatoxins, does not induce mitochondrial swelling or hinder Ca2+-induced swelling of mitochondria. Sterigmatocystin also inhibits acyl-CoA:cholesterol acyltransferase (ACAT) with selectivity for the ACAT2 isoenzyme.

Definition

ChEBI: An organic heteropentacyclic compound whose skeleton comprises a xanthene ring system ortho-fused to a dihydrofuranofuran moiety. The parent of the class of sterigmatocystins.

Hazard

Possible carcinogen; tumorigen; poison; mutagen; causes necrosis of the liver and kidney, and an inhibitory effect on orotic acid incorporation into nuclear RNA.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

It crystallises from amyl acetate, Me2CO or EtOH and sublimes in vacuo. It has UV max at 208, 235, 249 and 329nm (log  4.28, 4.39, 4.44 and 4.12). [UV: Bullock et al. J Chem Soc 4179, 1962, UV, IR: Holker & Mulheirn J Chem Soc, Chem Commun 1576, 1576 1968, Birkinshaw & Hammady Biochem J 65 162 1957.] This mycotoxin induces bone marrow changes in mice [Curry et al. Mutation Res 137 111 1984]. [Beilstein 19/10 V 575.]

STERIGMATOCYSTIN Preparation Products And Raw materials

Raw materials

Preparation Products


STERIGMATOCYSTIN Suppliers

Global( 53)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32362 50
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 sales@meilune.com China 4053 58
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+86-871-65215563 sales@mail.biobiopha.com China 5688 65
9ding chemical ( Shanghai) Limited 4009209199
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Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
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021-55660885 shjlsw@163.com China 10252 55
ChemStrong Scientific Co.,Ltd 0755 66853366
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Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 shenlinxing@macklin.cn China 15719 55

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