(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride
- CAS No.
- 36637-19-1
- Chemical Name:
- (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride
- Synonyms
- Duranest Hydrochloride;Etidocaine Hydrochloride;N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Hydrochloride;inhibit,Etidocaine Hydrochloride,Etidocaine,EDC,Inhibitor,anesthetics;(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride;(±)-N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Monohydrochloride;ButanaMide, N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)-, Monohydrochloride;Etidocaine hydrochlorideQ: What is Etidocaine hydrochloride Q: What is the CAS Number of Etidocaine hydrochloride Q: What is the storage condition of Etidocaine hydrochloride Q: What are the applications of Etidocaine hydrochloride
- CBNumber:
- CB1905513
- Molecular Formula:
- C17H29ClN2O
- Molecular Weight:
- 312.87796
- MDL Number:
- MFCD00941461
- MOL File:
- 36637-19-1.mol
- MSDS File:
- SDS
| Melting point | 203-203.5° |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | DMSO, Methanol |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | G6N3B3U8E6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Warning |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Toxicity | LD50 in female mice (mg/kg): 6.7 i.v.; 99 s.c. (Adams, 1972) |
(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | H37133 | Etidocaine hydrochloride 95% | 36637-19-1 | 100mg | $414.65 | 2024-03-01 | Buy |
| TRC | E932700 | Etidocaine hydrochloride | 36637-19-1 | 50mg | $340 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002648 | ETIDOCAINE HYDROCHLORIDE 95.00% | 36637-19-1 | 100MG | $329.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002648 | ETIDOCAINE HYDROCHLORIDE 95.00% | 36637-19-1 | 1G | $1963.5 | 2021-12-16 | Buy |
(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Chemical Properties,Uses,Production
Originator
Duranest,Astra,US,1976
Uses
Etidocaine Hydrochloride is a local anesthetic amide used during surgical procedures and during labor in pregnancies.
Definition
ChEBI: Etidocaine hydrochloride is an amino acid amide.
Manufacturing Process
α-(n-Propylamino)-n-butyro-2,6-xylidide(0.243 mol) and freshly distilled diethyl sulfate (1.6 mols were mixed in a flask equipped with reflux condenser, drying tube and stirrer. The mixture was stirred for 5 hours at 90°C. After cooling, water (110 ml) was added with stirring for 15 minutes followed by 4M HCl (110 ml). The solution was washed with ether (3 X 100 ml) and made alkaline with 7M NaOH to pH 10-11. The freed base was taken up in ether (3 X 100 ml); the extracts were dried over sodium sulfate, filtered and evaporated. The residue was dissolved in absolute ether (200 ml) and the hydrochloride prepared by addition of ethereal hydrogen chloride. The precipitate was filtered, washed with ether, and recrystallized twice from absolute ethanol/ether and from isopropanol/isopropylether; MP 203°C to 203.5°C; yield: 0.126 mol (52%). The starting material is prepared by reacting 2-bromobutyric acid with sulfonyl chloride to give the acid chloride. It is then reacted with 2,6-xylidine, then with potassium iodide followed by n-propylamine.
Therapeutic Function
Local anesthetic
Biological Functions
Etidocaine hydrochloride (Duranest), although chemically similar to lidocaine, has a more prolonged action. It is used for regional blocks, including epidural anesthesia. It exhibits a preference for motor rather than sensory block; therefore, its use in obstetrics is limited, although fetal drug concentrations remain low. It can be used with or without epinephrine.
(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9651 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9636 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4979 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |