Hydroxyapatite
- CAS No.
- 1306-06-5
- Chemical Name:
- Hydroxyapatite
- Synonyms
- HA;TRICALCIUM PHOSPHATE;CALCIUM HYDROXYAPATITE;HYDROXYLAPATITE;TRIBASIC CALCIUM PHOSPHATE;Apatite HAP;DURAPATITE;CALCIUM PHOSPHATE HYDROXIDE;BONE ASH;APATITE HAP, MONOCLINIC
- CBNumber:
- CB2131094
- Molecular Formula:
- Ca5HO13P3
- Molecular Weight:
- 502.31
- MDL Number:
- MFCD00010904
- MOL File:
- 1306-06-5.mol
- MSDS File:
- SDS
| Melting point | 1100 °C(lit.) |
|---|---|
| Density | 3.076 g/cm3(Temp: 18 °C) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.3 mg/mL, clear, colorless |
| form | solid |
| color | White |
| Water Solubility | insoluble H2O [MER06] |
| Merck | 13,3500 |
| InChI | InChI=1S/2Ca.H3O4P.H2O/c;;1-5(2,3)4;/h;;(H3,1,2,3,4);1H2/q2*+2;;/p-4 |
| InChIKey | CGMRCMMOCQYHAD-UHFFFAOYSA-J |
| SMILES | [Ca+2].[Ca+2].P([O-])([O-])([O-])=O.[OH-] |
| CAS DataBase Reference | 1306-06-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 91D9GV0Z28 |
| EPA Substance Registry System | Hydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5) |
| UNSPSC Code | 41116133 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | MY8434000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 28352600 |
| Hazardous Substances Data | 1306-06-5(Hazardous Substances Data) |
Hydroxyapatite price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 391947 | Hydroxylapatite, fast flow | 1306-06-5 | 100g | $701 | 2024-03-01 | Buy |
| Sigma-Aldrich | 21223 | Hydroxyapatite purum p.a., ≥90% (as Ca3(PO4)2, KT) | 1306-06-5 | 1kg | $194 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04238 | Hydroxyapatite ≥90% (calculated on glowed substance) | 1306-06-5 | 1kg | $136 | 2024-03-01 | Buy |
| Alfa Aesar | J60076 | Hydroxylapatite, fast flow | 1306-06-5 | 10g | $85.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60076 | Hydroxylapatite, fast flow | 1306-06-5 | 50g | $373 | 2024-03-01 | Buy |
Hydroxyapatite Chemical Properties,Uses,Production
Description
Calcium hydroxyapatite has a unique structure in
that it is conductive along the hydroxide channels.
OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on
the c-axis and charge-carrying protons are responsible
for the observed conductivities in M10(PO4)6(OH)2. The
H+ migration between the electroattractive ion (O2)
to give molecular H2O in matrix channels carries charge
and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells
forming a rhombic prism with vertical sides. There
are two horizontal mirror planes at the OH levels of 1/4
and 3/4 of the c-axis. In addition, there is a center of
inversion exactly in the center of each vertical face of
each subcell.
Chemical Properties
Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.
Chemical Properties
white powder
Occurrence
Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.
Uses
Prosthetic aid (artificial bone and teeth).
Uses
Hydroxyapatite and tricalcium phosphate are bioactive ceramic materials and they find applications as bone grafts, fillers and coating material for metal implants.
Uses
In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.
Preparation
The technical product is also known as “bone ash.” Commercial preparation from phosphate rock.
Definition
The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.
brand name
Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop).
General Description
Bone and tooth implant materials have been prepared from polycrystalline hydroxyapatite. The compressive, flexural, torsional and dynamic torsional strengths of polycrystalline hydroxyapatite were investigated. Electrophoretic deposition of hydroxyapatite on to flat titanium plate material has been studied.
Flammability and Explosibility
Not classified
Pharmaceutical Applications
Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ～50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.
Hydroxyapatite Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZhenYiBio Technology Inc | +8615309206328 | alexxue@zhenyibio.com | China | 298 | 58 |
| Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 | doris@njduly.com | China | 2450 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5854 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8772 | 58 |
| Hebei Dangtong Import and export Co LTD | +86-86-4001020630 +8619831957301 | admin@hbdangtong.com | China | 999 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18137 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3005 | 58 |
Related articles
- Hydroxyapatite: A Key Material in Chemistry and Biomedical Applications
- Hydroxylapatite is a hard, crystalline mineral composed of calcium, phosphate, and hydroxide ions that is the major constituen....
- Jan 7，2025
- Hydroxyapatite composites for orthopedic applications
- Hydroxyapatite composites show potential in tissue engineering for hip-joint implants with improved coatings and 3D printed sc....
- Dec 22，2023
- Hydroxyapatite: Biological function and applications
- Hydroxyapatite (HA) is a calcium phosphate bioceramic material, which is the major component and an essential ingredient of mi....
- Jul 7，2023
View Lastest Price from Hydroxyapatite manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-22 | Hydroxyapatite
1306-06-5
|
US $100.00-75.00 / kg | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-04-22 | Hydroxyapatite
1306-06-5
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | |
 |
2025-04-21 | Hydroxyapatite
1306-06-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Hydroxyapatite
1306-06-5
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Hydroxyapatite
1306-06-5
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd
-
- Hydroxyapatite
1306-06-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd