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Hydroxyapatite

Hydroxyapatite
Hydroxyapatite structure
CAS No.
1306-06-5
Chemical Name:
Hydroxyapatite
Synonyms
HA;HAw;monite;BONE ASH;Hydroxya;Bonedust;alveograf;periograf;HA, BOVINE;DURAPATITE
CBNumber:
CB2131094
Molecular Formula:
Ca5HO13P3
Formula Weight:
502.31
MOL File:
1306-06-5.mol

Hydroxyapatite Properties

Melting point:
1100 °C(lit.)
Density 
3.076 g/cm3(Temp: 18 °C)
storage temp. 
−20°C
solubility 
H2O: 0.3 mg/mL, clear, colorless
form 
solid
color 
White
Water Solubility 
insoluble H2O [MER06]
Merck 
13,3500
CAS DataBase Reference
1306-06-5(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylapatite (Ca5(OH)(PO4)3)(1306-06-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  MY8434000
3-10
TSCA  Yes
HS Code  28352600

Hydroxyapatite price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04238 Hydroxyapatite ≥90% (calculated on glowed substance) 1306-06-5 1kg $104 2018-11-22 Buy
Sigma-Aldrich 21223 Hydroxyapatite purum p.a., ≥90% (as Ca3(PO4)2, KT) 1306-06-5 1kg $149 2018-11-13 Buy
Alfa Aesar J60076 Hydroxylapatite, fast flow 1306-06-5 10g $71.6 2018-11-13 Buy
Alfa Aesar J60076 Hydroxylapatite, fast flow 1306-06-5 50g $255 2018-11-13 Buy
Sigma-Aldrich 391947 Hydroxyapatite 1306-06-5 100gm $281 2018-11-20 Buy

Hydroxyapatite Chemical Properties,Uses,Production

Description

Calcium hydroxyapatite has a unique structure in that it is conductive along the hydroxide channels. OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) on the c-axis and charge-carrying protons are responsible for the observed conductivities in M10(PO4)6(OH)2. The H+ migration between the electroattractive ion (O2) to give molecular H2O in matrix channels carries charge and the resulting conductivity.
The unit cell consists of two triangular prismatic subcells forming a rhombic prism with vertical sides. There are two horizontal mirror planes at the OH levels of 1/4 and 3/4 of the c-axis. In addition, there is a center of inversion exactly in the center of each vertical face of each subcell.

Chemical Properties

Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of a variable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O.

Chemical Properties

white powder

Occurrence

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.

Uses

Prosthetic aid (artificial bone and teeth).

Uses

In the 1970s, it was found that sintered calcium hydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated as CaHap), possessed excellent biocompatibility and nontoxicity with femur and mandible bones. Since then, CaHap has been used as a biomaterial for artificial teeth and bones and as a filler for cements and polymers. Today, bone fillers made of CaHap are widely used in the medical and dental fields. In the 1980s, it was found that sintered CaHap has a good compatibility with skin tissues. Hence, percutaneous devices based on CaHap have been developed and applications have included continuous ambulatory peritoneal dialysis and intravenous hyperalimentation systems, blood pressure measurement and blood access for nutrition. Recently, many researchers have studied the chemistry of apatites, particularly CaHap, and have found various applications, such as artificial teeth and bones, ion exchangers, adsorbents for chromatography to separate proteins and enzymes, catalysts, ionic conductors, temperature and gas sensors, etc.

Preparation

The technical product is also known as “bone ash.” Commercial preparation from phosphate rock.

Definition

The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth.

brand name

Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop).

Pharmaceutical Applications

Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makes up ~50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and a chemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despite similar or identical chemical compositions, the response of the body to these compounds can be quite different.

Hydroxyapatite Preparation Products And Raw materials

Raw materials

Preparation Products


Hydroxyapatite Suppliers

Global( 169)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8918 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2294 58
Shandong chuangyingchemical Co., Ltd.
13156170209
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BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58

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