Cefapirin sodium
- CAS No.
- 24356-60-3
- Chemical Name:
- Cefapirin sodium
- Synonyms
- CEPHAPIRIN;CEPHAPIRIN SODIUM;Today;CEFADYL;Cef-Lak;Piricef;blp1322;Ambrocef;Cefa-Lak;Bristocef
- CBNumber:
- CB2189257
- Molecular Formula:
- C17H18N3NaO6S2
- Molecular Weight:
- 447.46
- MDL Number:
- MFCD07793329
- MOL File:
- 24356-60-3.mol
- MSDS File:
- SDS
| Melting point | >177°C (dec.) |
|---|---|
| alpha | +152～+170゜(25℃/D)(c=2,H2O)(calculated on the dehydrous basis) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in water, practically insoluble in methylene chloride. |
| form | powder |
| pka | pKa 2.15 (Uncertain) |
| color | Light Beige to Beige |
| InChIKey | VGEOUKPOQQEQSX-OALZAMAHSA-M |
| CAS DataBase Reference | 24356-60-3(CAS DataBase Reference) |
| FDA 21 CFR | 556.115 |
| FDA UNII | 431LFF7I7J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H317-H319-H334-H335 |
| Precautionary statements | P261-P280-P284-P304+P340-P305+P351+P338-P342+P311 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 26-36 |
| RTECS | XI0382000 |
| HS Code | 2941906000 |
Cefapirin sodium price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000240 | Cefapirin sodium European Pharmacopoeia (EP) Reference Standard | 24356-60-3 | y0000240 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | SMB00605 | Cephapirin sodium ≥96% | 24356-60-3 | 25mg | $321 | 2023-06-20 | Buy |
| Sigma-Aldrich | 1102500 | Cephapirin sodium United States Pharmacopeia (USP) Reference Standard | 24356-60-3 | 500mg | $436 | 2024-03-01 | Buy |
| TRC | C261510 | Cephapirin sodium | 24356-60-3 | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0031236 | Cephapirin sodium 99.59% | 24356-60-3 | 100mg | $135 | 2021-12-16 | Buy |
Cefapirin sodium Chemical Properties,Uses,Production
Description
Cephapirin sodium (Cefapirin sodium), a semisynthetic cephalosporin antibiotic, is bactericidal against strains of gram-positive and gram-negative bacteria.
Cephapirin is closely resembles cephalothin in chemical and pharmacokinetic properties. Cephapirin, have cephalosporanic acid core with the acetyloxymethyl group at the 3rd position and having IUPAC name (6R,7R)-3-(Acetoxymethy)-8- oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia- 1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid. It is unstable in acid and must be administered parenteral. It has similar mechanism as other cephalosporins. It is marketed under the trade name Cefadyl. It is effective against a wide variety of gram-positive and gramnegative bacteria; used as the sodium salt. Among the most serious adverse reactions of cefapirin, that is， neutropenia, leukopenia, anemia, bone marrowdepression, and allergic reactions, it has been discontinued in the United States (Wiesner, 1972).
Chemical Properties
White or pale yellow powder.
Originator
Cefadyl,Bristol,US,1974
Uses
Cefapirin sodium is very similar to cephalothin (Bran et al., 1972). Cephapirin is now used almost exclusively in veterinary practice.
Definition
ChEBI: Cephapirin sodium is the sodium salt of cephapirin. A first-generation cephalosporin antibiotic, it is effective against gram-negative and gram-positive organisms. Being more resistant to beta-lactamases than penicillins, it is effective agains most staphylococci, though not methicillin-resistant staphylococci. It has a role as an antibacterial drug. It is a cephalosporin and an organic sodium salt. It contains a cephapirin(1-).
Application
Cephapirin was synthesized by BristolMyers Laboratories in 1970. It shows almost the same in vitro antibacterial activity as cephalothin, but its in vivo effects are slightly greater than those of cephalothin. Like cephalothin, it is metabolized in vivo, and its deacetylated metabolite shows almost the same activity against gram-positive bacteria as cephalothin, but weaker activity against gramnegative bacteria. Cephapirin has been used for therapy of urinary tract infections and osteomyelitis caused by Staphylococcus, Streptococcus, and Escherichia coli.
brand name
Cefadyl (Apothecon).
Therapeutic Function
Antibacterial
Synthesis
Cephapirin, (6R-trans)-3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)
acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.4), is synthesized by acylating 7-aminocephalosporanic acid with 4-pyridylthioacetic acid chloride
(32.1.2.3), which is synthesized by reacting 4-chloropyridine with mercaptoacetic acid in
the presence of a base, forming 4-pyridylthioacetic acid (32.1.22), and further transforming the resulting acid to the acid chloride by reacting it with phosphorous pentachloride.
An alternative way of making cephapirin is the acylation of 7-aminocephalosporanic acid
by bromoacetyl bromide, which gives a bromoacetyl derivative (32.1.2.5), and which is
then reacted with 4-mercaptopyridine in the presence of triethylamine, forming the desired
cephapirin (32.1.2.4).
Cefapirin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
View Lastest Price from Cefapirin sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-05-17 | Cefapirin sodium
24356-60-3
|
US $1.10 / g | 1g | 99.9% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2021-11-23 | Cefapirin sodium
24356-60-3
|
US $10.00 / g | 100g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-07-01 | CEFAPIRIN USP/EP/BP | US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Cefapirin sodium
24356-60-3
- US $1.10 / g
- 99.9% Min
- Dideu Industries Group Limited
-
- Cefapirin sodium
24356-60-3
- US $10.00 / g
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- CEFAPIRIN USP/EP/BP
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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