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(-)-Epigallocatechin gallate

(-)-Epigallocatechin gallate
(-)-Epigallocatechin gallate structure
CAS No.
989-51-5
Chemical Name:
(-)-Epigallocatechin gallate
Synonyms
EGCG;ECGC;E-5187;(EGCE);Egcg90%;Teavigo;EGCG-d6;(-)-EGCG;479-560-7;Teavigo TG
CBNumber:
CB2227188
Molecular Formula:
C22H18O11
Formula Weight:
458.37
MOL File:
989-51-5.mol

(-)-Epigallocatechin gallate Properties

Melting point:
222-224°C
alpha 
D -185 ±2°(ethanol)
refractive index 
-175.5 ° (C=1, EtOH)
storage temp. 
2-8°C
solubility 
H2O: ≥5mg/mL, clear
pka
7.75±0.25(Predicted)
Boiling point:
909.1±65.0 °C(Predicted)
Density 
1.90±0.1 g/cm3(Predicted)
form 
neat
Water Solubility 
Soluble in ethanol, dimethyl formamide, water.
Merck 
14,3526
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey
WMBWREPUVVBILR-WIYYLYMNSA-N
CAS DataBase Reference
989-51-5(CAS DataBase Reference)
EWG's Food Scores
2
FDA UNII
BQM438CTEL
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Safety Statements  24/25
WGK Germany  2
RTECS  KB5200000
10-23
HS Code  29339900
Toxicity LD50 oral in mouse: 2170mg/kg

(-)-Epigallocatechin gallate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 03970590 Epigallocatechin gallate primary pharmaceutical reference standard 989-51-5 10mg $209 2019-12-02 Buy
Sigma-Aldrich 1236700 (?)-Epigallocatechin gallate United States Pharmacopeia (USP) Reference Standard 989-51-5 20mg $313.6 2019-12-02 Buy
TCI Chemical E0694 (-)-Epigallocatechin Gallate Hydrate >98.0%(HPLC) 989-51-5 100mg $120 2019-12-02 Buy
TCI Chemical E0694 (-)-Epigallocatechin Gallate Hydrate >98.0%(HPLC) 989-51-5 500mg $360 2019-12-02 Buy
Alfa Aesar J61745 (-)-Epigallocatechin gallate 989-51-5 50mg $89 2019-12-02 Buy

(-)-Epigallocatechin gallate Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

telomerase inhibitor

Uses

An inhibitor of Bcl-2 and NOS2

Uses

A tumor-inhibiting constituent of green tea. Alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice

Hazard

Moderately toxic by ingestion.

Anticancer Research

EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013).

Anticancer Research

EGCG is an ester of gallic acid and epigallocatechin and is a catechin compound(Murakami et al. 1996). It is found most abundantly in green tea. It can be used to treat brain, prostate, cervical, and bladder cancers (Wang et al. 2012). It suppressesthe ornithine decarboxylase action, an enzyme that leads to rapid proliferation andfurthermore circumvents apoptosis (Singh et al. 2016a). It suppresses nuclear factor(NF-κB) activation and expression of Bcl-2 (B-cell lymphoma 2) as well as COX-2(cyclooxygenase-2) in prostate cancer cells and causes induction of apoptosis. Ithamper the matrix metallopeptidase-9 (MMP-9) activation in bladder and lungcancer cells and suppresses the synthesis of VGEF (vascular endothelial growthfactor) in head and neck cancers. It prevents ERK (extracellular signal-regulatedkinase) phosphorylation and MMP-2 and MMP-9 activation and suppresses ERK,c-Jun N-terminal kinase (JNK), and MMP-9 expressions in gastric carcinoma cells(Singh et al. 2016a). It is binding and inhibits the antiapoptotic protein Bcl-xL,interferes with EGFR (epidermal growth factor receptor) signaling, and inhibitshepatocyte growth factor-induced cell proliferation and MAPK (mitogen-activatedprotein kinase), CDK (cyclin-dependent kinase), and cell signaling linked to growthfactors (Wang et al. 2012; Du et al. 2012).
Green tea constitutes the rich amount of EGCG which aids in cancer chemoprevention(Fujiki et al. 1998). EGCG improved the impacts of ginseng compoundin the restraint of colon tumor cell development, showing that green tea could bea successful synergist with an anticancer agent for malignancy chemoprevention.It obstructs the PDGF-initiated proliferation and migration of rodent pancreaticstellate cells (Masamune et al. 2005). The soluble and plasma membrane-integratedEGCG straightforwardly communicates with PDGF-BB and in this wayputs off precise receptor binding promoting the inhibitory impacts of EGCG onplatelet-derivedgrowth factor-incited cell signaling and mitogens (Weber et al.2004).

(-)-Epigallocatechin gallate Preparation Products And Raw materials

Raw materials

Preparation Products


(-)-Epigallocatechin gallate Suppliers

Global( 328)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20114 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47484 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19920 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
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Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30053 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58

View Lastest Price from (-)-Epigallocatechin gallate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 (-)-Epigallocatechin gallate in stock Factory
989-51-5
US $1.00 / kg 1kg High quality purified manufacturer Top 3 production capacity Factory Chemwill Asia Co.,Ltd.
2019-07-02 egcg Epigallocatechin gallate 989-51-5
989-51-5
US $48.00 / g 10mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2019-07-09 Epigallocatechin gallate 989-51-5
989-51-5
US $45.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

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