6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- CAS No.
- 179248-59-0
- Chemical Name:
- 6,7-Dimethoxy-N-(4-phenoxyphenyl)-
- Synonyms
- Edr;HHAT;HB-1;Mar2;MART2;SKI-1;MEF3L;Src I1;Src-l1;Src Inhibitor-1
- CBNumber:
- CB22508388
- Molecular Formula:
- C22H19N3O3
- Molecular Weight:
- 373.4
- MDL Number:
- MFCD01815300
- MOL File:
- 179248-59-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H413 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P405-P501a-P280-P301+P312+P330-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
6,7-Dimethoxy-N-(4-phenoxyphenyl)- price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S2075 | Src Inhibitor-1 ≥98% (HPLC) | 179248-59-0 | 5mg | $174 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB1303011 | ANTI-HHAT (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 400μL | $481 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB5300036 | Monoclonal Anti-PEG10 antibody produced in mouse clone 4C10A7, ascites fluid | 179248-59-0 | 100μL | $503 | 2023-01-07 | Buy |
| Sigma-Aldrich | SAB5300035 | Monoclonal Anti-PEG10 antibody produced in mouse clone 1B1C4, ascites fluid | 179248-59-0 | 100μL | $503 | 2023-01-07 | Buy |
| Alfa Aesar | J67242 | Src Inhibitor-1 98% | 179248-59-0 | 5mg | $120 | 2021-12-16 | Buy |
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Chemical Properties,Uses,Production
Description
Src-I1 (179248-59-0) is a potent and competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50‘s = 44 nM for Src and 88 nM for Lck). Src-I1 also inhibits VEGFR2 (IC50 = 320 nM).
Uses
Src Kinase inhibitor 1 lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy
Uses
Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.
Definition
ChEBI: Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether.
General Description
A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC50 = 320 nM and 30 μM, respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
1) Tian et al. (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines; Biochem. 40 7084 2) Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem. J. 408 297
6,7-Dimethoxy-N-(4-phenoxyphenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
View Lastest Price from 6,7-Dimethoxy-N-(4-phenoxyphenyl)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 46,7-Dimethoxy-N-(4-phenoxyphenyl)-
179248-59-0
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- 46,7-Dimethoxy-N-(4-phenoxyphenyl)-
179248-59-0
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co