Deltarasin
- CAS No.
- 1440898-61-2
- Chemical Name:
- Deltarasin
- Synonyms
- Deltarasin;deltarasine;Deltarasin-HCl;Deltarasin USP/EP/BP;Deltarasin,Phosphodiesterase (PDE),inhibit,Inhibitor,Ras;(S)-1-benzyl-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole;2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole;1H-Benzimidazole,2-[4-[(2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-
- CBNumber:
- CB22666619
- Molecular Formula:
- C40H37N5O
- Molecular Weight:
- 603.75
- MDL Number:
- MFCD26793865
- MOL File:
- 1440898-61-2.mol
| Boiling point | 824.3±75.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 10.35±0.10(Predicted) |
| color | White |
| CAS DataBase Reference | 1440898-61-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Deltarasin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5424 | Deltarasin ≥99%(HPLC) | 1440898-61-2 | 10 | $254 | 2021-12-16 | Buy |
| Usbiological | 446059 | Deltarasin | 1440898-61-2 | 2.5mg | $425 | 2021-12-16 | Buy |
| Usbiological | 255122 | Deltarasin | 1440898-61-2 | 10mg | $545 | 2021-12-16 | Buy |
| TRC | D231315 | Deltarasin | 1440898-61-2 | 5mg | $185 | 2021-12-16 | Buy |
| ChemScene | CS-1611 | Deltarasin 96.32% | 1440898-61-2 | 10mg | $252 | 2021-12-16 | Buy |
Deltarasin Chemical Properties,Uses,Production
Uses
Deltarasin is an inhibitior of KRAS-PDEδ which has been shown to impair oncogenic signalling.
Biological Activity
the kras oncogene product is considered a major target in anticancer drug discovery. interfering with binding of mammalian pdeδ to kras by means of small molecules provides a novel opportunity to suppress oncogenic ras signalling by altering its localization to endomembranes. deltarasin is an inhibitor of the kras-pdeδ interaction to impair oncogenic kras signalling.
in vitro
within a minute, 5 mm of deltarasin completely inhibited pdeδ-kras interaction and released the insolubilized mcitrine-rheb/kras6q to the endomembrane system. this showed that deltarasin interfered with the binding of kras to pdeδ in cells and thereby inhibited its solubilization [1].
in vivo
a clear dose-dependent reduction in panc-tu-i tumour growth rate could be observed in deltarasin treated mice with respect to the vehicle-injected controls, where the growth of tumours in mice that were treated with 10mg kg/1 bid deltarasin was almost completely blocked [1].
References
[1] zimmermann g, papke b, ismail s, vartak n, chandra a, hoffmann m, hahn sa, triola g, wittinghofer a, bastiaens pi, waldmann h. small molecule inhibition of the kras-pdeδ interaction impairs oncogenic kras signalling. nature. 2013;497(7451):638-42.
Deltarasin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
View Lastest Price from Deltarasin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Deltarasin
1440898-61-2
|
US $0.00-0.00 / KG | 5mg | 99% HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Deltarasin
1440898-61-2
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Deltarasin
1440898-61-2
- US $0.00-0.00 / KG
- 99% HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- Deltarasin
1440898-61-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co