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Tributyl citrate

Outline New non-toxic plasticizer Chemical properties Uses
Tributyl citrate
Tributyl citrate structure
CAS No.
77-94-1
Chemical Name:
Tributyl citrate
Synonyms
nsc8491;citroflex4;Citroflex 4;Citroflex 4C;BUTYL CITRATE;N-BUTYLCITRATE;Tributylcitrat;tributyl ester ;TRIBUTYL CITRATE;TRI-N-BUTYL CITRATE
CBNumber:
CB2299345
Molecular Formula:
C18H32O7
Formula Weight:
360.44
MOL File:
77-94-1.mol

Tributyl citrate Properties

Melting point:
≥300 °C(lit.)
Boiling point:
234 °C (17 mmHg)
Density 
1.043 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.445
Flash point:
300 °C
storage temp. 
Store below +30°C.
solubility 
Miscible with acetone, ethanol, and vegetable oil; practically insoluble in water.
form 
Liquid
pka
11.30±0.29(Predicted)
color 
Clear
Water Solubility 
insoluble
Merck 
14,1564
BRN 
1806072
InChIKey
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N
Indirect Additives used in Food Contact Substances
TRIBUTYL CITRATE
CAS DataBase Reference
77-94-1(CAS DataBase Reference)
FDA 21 CFR
175.105
EWG's Food Scores
1
FDA UNII
827D5B1B6S
NIST Chemistry Reference
Butyl citrate(77-94-1)
EPA Substance Registry System
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tributyl ester (77-94-1)
SAFETY
  • Risk and Safety Statements
Hazard Codes  T
Risk Statements  25
Safety Statements  26-36/37/39-45-24/25
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  TZ8608000
TSCA  Yes
HS Code  29181500
NFPA 704
1
0 0

Tributyl citrate price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 27497 Tributyl citrate ≥97.0% 77-94-1 100ml-f $79 2020-08-18 Buy
Sigma-Aldrich 1680608 Tributyl citrate United States Pharmacopeia (USP) Reference Standard 77-94-1 500mg $399 2020-08-18 Buy
TCI Chemical C0366 Tributyl Citrate >98.0%(GC) 77-94-1 25mL $19 2020-06-24 Buy
TCI Chemical C0366 Tributyl Citrate >98.0%(GC) 77-94-1 500mL $71 2020-06-24 Buy
Alfa Aesar A10266 Tri-n-butyl citrate, 99% 77-94-1 50g $20.4 2020-06-24 Buy

Tributyl citrate Chemical Properties,Uses,Production

Outline

Tributyl citrate (TBC) is a good environmental plasticizers, lubricants. At room temperature, it is non-toxic, it has fruit flavor, it is colorless oily liquid. Boiling point is 170℃ (133.3Pa), flash point (open cup) is 185℃. It is soluble in most organic solvents. Volatile is small, it has good compatibility with the resin, it has high efficiency in plastification, in Europe and other countries it is allowed for food packaging and medical products, as well as children's soft toys, pharmaceuticals, medical products, flavors and fragrances, cosmetics manufacturing and other industries.Products can be given a good cold resistance, water resistance and mildew resistance. The product which is resin plasticized can exhibit good transparency and low temperature flexural properties, and has low volatility and low extraction resistance in different media, thermal stability, it does not change color when be heat. The product which prepared by lubricating oil can have good lubricating properties.

New non-toxic plasticizer

The most commonly used plasticizer is phthalate esters industrially, because it can induce cancer, the use in foreign countries has been controlled strictly , China has also formulated relevant laws and regulations, and will phase out its use in food packaging materials, medical appliances toys . Tributyl citrate (TBC) is a new non-toxic plasticizer, because it has good compatibility, high plasticizing efficiency, non-toxic and less volatile, weather resistance and other characteristics of broad interest, it is used as the preferred alternative green products in place of phthalic dimethyl esters. With the growing awareness of environmental protection and improvement of environmental regulations, the development and production of tributyl citrate has excellent prospects.
Tributyl citrate is usually caused with citric acid and n-butanol in the presence of catalyst by esterifying, the conventional catalyst is concentrated sulfuric acid, although its low price, high catalytic activity, it can cause serious corrosion for equipment, post-processing process is complex, the select of reaction is poor, environmental pollution is serious and other defects, and thus the work of seeking alternative catalysts in place of concentrated sulfuric acid is very active, some better catalytic effect of the catalyst has been found:
[Sodium bisulfate catalytic synthesis of tributyl citrate]
Monohydrate Sodium hydroxide is a strong ionic compounds, the study found that it is soluble in water, aqueous solution is strongly acidic but it is insoluble in organic acids and alcohols reaction system, it can be used as a catalyst for esterification, studies show that the catalyst has a high activity catalytic, good stability, high yield, easy separation, convenient synthesis method, no corrosion, no pollution and other advantages.
[Synthesis of solid superacid catalyst]
Superacid is an acid, which the strength is greater than 100% sulfuric acid. Studies have shown that using it as a catalyst for the esterification reaction has good selectivity, fast response, high yield, easy separation, ease of operation, and the catalyst is stable, reusable, non-corrosive, non-polluting, it is a kind of promising catalyst.
[Synthesis of p-toluenesulfonic acid catalysis]
Toluenesulfonic acid is a strong organic acid, it can be used to instead of concentrated sulfuric acid as the esterification catalyst, and the corrosion for equipment and waste pollution is much smaller than that of sulfuric acid, it is also high activity and selectivity, cheap, dosage less, good product color, it is fit catalyst for industrial production.
[Miscellaneous catalytic synthesis of tributyl citrate]
Heteropolyacid is a multi-proton acid, the stronger of acidity, the more conducive to the formation of salt, it provide more favorable conditions for other nucleophilic attack, thus it speeds up the rate of the esterification reaction. It is non-volatile, the thermal stability is well, it also cause less pollution and can reduce equipment corrosion, it is an ideal esterification catalyst.
The above information is edited by the chemicalbook of Wang Xiaodong.

Chemical properties

It is colorless, oily liquid, slightly scented. It is insoluble in water, soluble in methanol, acetone, carbon tetrachloride, acetic acid, castor oil, mineral oil, organic solvents.

Uses

This product is innocuous plasticizer, it can be used for granulation of non-toxic PVC, it can be used for packaging materials in food production, soft toys for children, medical products, the plasticizer for polyvinyl chloride, vinyl chloride copolymers, cellulose resin.

Chemical Properties

Colorless or pale-yellow, stable, odorless, nonvolatile liquid. Practically insoluble in water. Combustible.

Chemical Properties

Tributyl citrate is a clear, odorless, practically colorless, oily liquid.

Uses

Plasticizer and solvent for nitrocellulose lacquers; in polishes, inks and similar Preparations; also as anti-foam agent.

Production Methods

Tributyl citrate is prepared by the esterification of citric acid with butanol.

Pharmaceutical Applications

Tributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.

Safety

Tributyl citrate is used in oral pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): 2.9 g/kg
LD50 (rat, oral): >30 mL/kg

storage

Tributyl citrate should be stored in well-closed containers in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, tributyl citrate is a stable material.

Incompatibilities

Tributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Approved in the USA for indirect food contact in food films. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Tributyl citrate Preparation Products And Raw materials

Raw materials

Preparation Products


Tributyl citrate Suppliers

Global( 263)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10132 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58

View Lastest Price from Tributyl citrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-21 Tributyl Citrate
77-94-1
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2018-12-18 Tributyl citrate
77-94-1
US $1.00 / kg 1kg 98% 1000kg career henan chemical co

Tributyl citrate Spectrum


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