3-TROPANYL-3,5-DICHLOROBENZOATE
- CAS No.
- 40796-97-2
- Chemical Name:
- 3-TROPANYL-3,5-DICHLOROBENZOATE
- Synonyms
- MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE
- CBNumber:
- CB2317210
- Molecular Formula:
- C15H17Cl2NO2
- Molecular Weight:
- 314.21
- MDL Number:
- MFCD00865533
- MOL File:
- 40796-97-2.mol
- MSDS File:
- SDS
| Melting point | 165 °C |
|---|---|
| Boiling point | 406.5±45.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | 0.1 M HCl: slightly soluble |
| form | solid |
| pka | 9.89±0.40(Predicted) |
| color | white |
| Water Solubility | Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol. |
| FDA UNII | O98T3677PA |
3-TROPANYL-3,5-DICHLOROBENZOATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J62583 | 3-Tropanyl-3,5-dichlorobenzoate, 99+% | 40796-97-2 | 50mg | $247 | 2021-12-16 | Buy |
| Tocris | 0640 | MDL72222 ≥99%(HPLC) | 40796-97-2 | 50 | $149 | 2021-12-16 | Buy |
| TRC | M199805 | MDL-72222 | 40796-97-2 | 100mg | $185 | 2021-12-16 | Buy |
| Usbiological | 255769 | MDL 72222 | 40796-97-2 | 50mg | $389 | 2021-12-16 | Buy |
| ApexBio Technology | B6389 | MDL72222 | 40796-97-2 | 10mg | $189 | 2021-12-16 | Buy |
3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Uses,Production
Originator
Bemesetron,Merrel Dow
Uses
It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.
Uses
Anti-emetic.
Manufacturing Process
Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).
Therapeutic Function
Serotonin antagonist
Biological Activity
5-HT 3 antagonist.
storage
Store at RT
3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials
3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9635 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9636 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |