ST034307
- CAS No.
- 133406-29-8
- Chemical Name:
- ST034307
- Synonyms
- ST034307;ST034307 >=98% (HPLC);ST034307;ST-034307;ST 034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
- CBNumber:
- CB23356179
- Molecular Formula:
- C10H4Cl4O2
- Molecular Weight:
- 297.95
- MDL Number:
- MFCD00760793
- MOL File:
- 133406-29-8.mol
- MSDS File:
- SDS
| Boiling point | 329.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.674±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml) |
| form | solid |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
ST034307 price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 5mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 10mg | $264 | 2024-03-01 | Buy |
| Cayman Chemical | 21777 | ST034307 ≥95% | 133406-29-8 | 25mg | $576 | 2024-03-01 | Buy |
| Tocris | 6271 | ST034307 ≥98%(HPLC) | 133406-29-8 | 50 | $590 | 2021-12-16 | Buy |
ST034307 Chemical Properties,Uses,Production
Description
ST-034307 (133406-29-8) is a?novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. ?It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1,3?Displays analgesic properties in a mouse model of inflammatory pain.1?A useful tool for exploring the involvement of AC1 in cellular signalling.2
Uses
ST 034307 is a useful intermediate.
storage
Store at -20°C
References
1) Brust?et al.?(2017),?Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties; Sci. Signal,?10?eaah5381 2) Jiang?et al,?(2018),?Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells;. Cell?175?652 3) Watts (2018),?Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain;?Neuropsychopharmacology?43?215
ST034307 Preparation Products And Raw materials
Raw materials
Preparation Products
ST034307 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai SunSyn Pharmaceutical Co., Ltd. | -2408801818 18621020637 | sales@sunsynpharma.com | China | 293 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9838 | 58 |