PICROTIN
- CAS No.
- 21416-53-5
- Chemical Name:
- PICROTIN
- Synonyms
- PICROTIN;Picrotin CRS;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-;(1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
- CBNumber:
- CB2383778
- Molecular Formula:
- C15H18O7
- Molecular Weight:
- 310.3
- MDL Number:
- MFCD00868514
- MOL File:
- 21416-53-5.mol
- MSDS File:
- SDS
Melting point | 256-258°C |
---|---|
alpha | D -64.7° (c = 2.31 in abs alc) |
Boiling point | 595.8±50.0 °C(Predicted) |
Density | 1.59 |
storage temp. | 2-8°C |
solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml |
pka | 13.28±0.60(Predicted) |
form | Solid |
color | White to off-white |
EWG's Food Scores | 1 |
FDA UNII | U06Z6QD7N2 |
EPA Substance Registry System | Picrotin (21416-53-5) |
SAFETY
Risk and Safety Statements
WGK Germany | 3 |
---|---|
RTECS | TJ8800000 |
Toxicity | LD50 i.p. in mice: 135 mg/kg (Jarboe) |
PICROTIN price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | Y0001508 | Picrotin European Pharmacopoeia (EP) Reference Standard | 21416-53-5 | y0001508 | $220 | 2024-03-01 | Buy |
Cayman Chemical | 21870 | Picrotin ≥98% | 21416-53-5 | 25mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21870 | Picrotin ≥98% | 21416-53-5 | 50mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 21870 | Picrotin ≥98% | 21416-53-5 | 100mg | $98 | 2024-03-01 | Buy |
Cayman Chemical | 21870 | Picrotin ≥98% | 21416-53-5 | 250mg | $169 | 2024-03-01 | Buy |
PICROTIN Chemical Properties,Uses,Production
Description
Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.
Uses
GABAa receptor antagonist
Definition
ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.
PICROTIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
21416-53-5(PICROTIN)Related Search:
1of4