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PICROTIN

PICROTIN structure

CAS No.: 21416-53-5

Chemical Name:: PICROTIN

Synonyms: PICROTIN;Picrotin CRS;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-;(1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione

CBNumber:: CB2383778

Molecular Formula:: C15H18O7

Molecular Weight:: 310.3

MDL Number:: MFCD00868514

MOL File:: 21416-53-5.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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PICROTIN Properties

Melting point	256-258°C
alpha	D -64.7° (c = 2.31 in abs alc)
Boiling point	595.8±50.0 °C(Predicted)
Density	1.59
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
pka	13.28±0.60(Predicted)
EWG's Food Scores	1
FDA UNII	U06Z6QD7N2
EPA Substance Registry System	Picrotin (21416-53-5)

SAFETY

Risk and Safety Statements

WGK Germany	3
RTECS	TJ8800000
Toxicity	LD50 i.p. in mice: 135 mg/kg (Jarboe)

PICROTIN price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001508	Picrotin European Pharmacopoeia (EP) Reference Standard	21416-53-5	y0001508	$220	2024-03-01	Buy
Cayman Chemical	21870	Picrotin ≥98%	21416-53-5	25mg	$32	2024-03-01	Buy
Cayman Chemical	21870	Picrotin ≥98%	21416-53-5	50mg	$57	2024-03-01	Buy
Cayman Chemical	21870	Picrotin ≥98%	21416-53-5	100mg	$98	2024-03-01	Buy
Cayman Chemical	21870	Picrotin ≥98%	21416-53-5	250mg	$169	2024-03-01	Buy

Product number	Packaging	Price	Buy
Y0001508	y0001508	$220	Buy
21870	25mg	$32	Buy
21870	50mg	$57	Buy
21870	100mg	$98	Buy
21870	250mg	$169	Buy

PICROTIN Chemical Properties,Uses,Production

Description

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC₅₀s = 57 and 117 μM for α₁ and α₂ homodimeric GlyRs, respectively). It also inhibits α₃ homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.

Uses

GABAa receptor antagonist

Definition

ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.

PICROTIN Preparation Products And Raw materials

Raw materials

Preparation Products

PICROTIN Suppliers

Global( 69)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006608290; 18621169109	market03@meryer.com	China	40241	62
Chengdu Climax Biotech Co., Ltd.	028-83311324 1278112614	climaxbiotech@gmail.com	China	925	58
Shanghai Tauto Biotech Co., Ltd.	021-51320588	tauto@tautobiotech.com	China	3989	66
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Chengdu Climax Biotech Co., Ltd.	58
Shanghai Tauto Biotech Co., Ltd.	66
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58

PICROTIN Spectrum

PICROTIN(21416-53-5)¹HNMR

21416-53-5(PICROTIN)Related Search:

PICROTIN (R)-5-Hydroxymethyldihydrofuran-2-one ETHYL N-HEPTYLOXYACETATE 3-HEPTYLDIHYDRO-5-METHYL-2(3H)-FURANONE ETHYL TETRAHYDROPYRAN-4-YL-ACETATE

cis-4-Hydroxycyclohexanecarboxylic acid Tetrahydropyranyl-4-acetic acid ε-Caprolactone D-(-)-PANTOLACTONE 4-METHOXYCYCLOHEXANECARBOXYLIC ACID

TETRAHYDROFURFURYL BUTYRATE Undecanedioic acid DL-Pantolactone Molecular complex (1:1) of picrotin and picrotoxinin,picrotin,compd.withpicrotoxinin(1:1 TRANS-P-MENTHANE-3,8-DIOL

METHYL 2-METHYLGLYCIDATE 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER 6-OXABICYCLO[3.2.1]OCTAN-7-ONE

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PICROTIN (1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione Picrotin CRS 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)- 21416-53-5 C15H18O7 Analytical Standards Analytical Chromatography Product Catalog Alphabetic PEM - POLA Plant Oils, Toxins, Phenolic Acids & Derivatives