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Ozagrel

CAS No.
82571-53-7
Chemical Name:
Ozagrel
Synonyms
Xanbon;Ozagre;OKY-046;OZAGREL;Cataclot;Ozagrel API;Ozagrel, ≥98%;Mr Zardari gray;Ozagrel(OKY-046);OzagrelSodium99%
CBNumber:
CB2734655
Molecular Formula:
C13H12N2O2
Molecular Weight:
228.25
MDL Number:
MFCD00868231
MOL File:
82571-53-7.mol
Last updated:2023-09-22 17:54:45

Ozagrel Properties

Melting point 223-224°
Boiling point 468.0±25.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO : 50 mg/mL (219.06 mM; Need ultrasonic)
form Powder
pka 4.43±0.10(Predicted)
CAS DataBase Reference 82571-53-7(CAS DataBase Reference)
FDA UNII L256JB984D

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Ozagrel price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70515 Ozagrel ≥98% 82571-53-7 5mg $34 2024-03-01 Buy
Cayman Chemical 70515 Ozagrel ≥98% 82571-53-7 10mg $64 2024-03-01 Buy
Cayman Chemical 70515 Ozagrel ≥98% 82571-53-7 50mg $264 2024-03-01 Buy
Cayman Chemical 70515 Ozagrel ≥98% 82571-53-7 100mg $459 2024-03-01 Buy
TRC O880003 Ozagrel 82571-53-7 25mg $125 2021-12-16 Buy
Product number Packaging Price Buy
70515 5mg $34 Buy
70515 10mg $64 Buy
70515 50mg $264 Buy
70515 100mg $459 Buy
O880003 25mg $125 Buy

Ozagrel Chemical Properties,Uses,Production

Platelet aggregation inhibitor

Ozagrel and clopidogrel, cilostazol, aspirin enteric-coated tablets are commonly used in China at present as platelet aggregation inhibitor, Ozagrel is an anti-thrombosis drug which belongs to a thromboxane alkyl cyclooxygenase (TXA2) inhibitors, originally it was successfully developed by Japan Ono pharmaceutical Co., Ltd. and Kissei pharmaceutical Co., Ltd. ,it was approved for marketing in Japan in 1988. At present, domestic manufacturers include the Liaoning dandong, medical and pharmaceutical industry, Shandong Elohim Pharmaceutical Co., Changchun fine distinctions Pharmaceutical, Dalian Metro big pharmaceutical companies, pharmaceutical Shenyang Jishi, Hainan bikai Pharmaceutical, Changchun Haobang Pharmaceutical and Shandong HuaLu pharmaceutical. Modern medicine has proved that platelets play an important role in the process of atherosclerosis and thrombosis, the effective regulation of platelet can play a multiplier effect on blood vessel lumen stenosis, emboli and diseases caused by occlusion of blood circulatory system . At present, the platelet aggregation inhibitor drugs used clinically are mainly cyclooxygenase (TXA2) inhibitors, phosphodiesterase (PDE) inhibitors, adenosine diphosphate (ADP) receptor antagonists, platelet fibrinogen antagonists drugs.
Ozagrel sodium salt has a strong antithrombotic effect, which is the world's first listing inhibitor of the potent thromboxane synthase feature ,it has the inhibiting effect on the platelet aggregation induced by different inducers (such as collagen, arachidonic acid, epinephrine, ADP, 5-HT, etc.) ,it can inhibit TXA2 synthase, while it can promot the generation of PGI2, it has effect on anti-platelet aggregation and relieving the vasospasm, it can inhibit the cerebral thrombosis and cerebral vasospasm. It is Mainly applied to the improvement of subarachnoid hemorrhage after cerebral vasospasm and cerebral ischemic symptoms. It can reduce cerebral infarction fibrin, and factor I,it can reduce blood viscosity and inhibit platelet aggregation.in the cerebral embolism model tests caused by the injection of arachidonic acid , after taking the product ,the occurrence of cerebral thrombosis is suppressed , animal mortality is decreased, while not only the cerebral movement disorders of acute phase is improved , but also the circulatory disorders of the acute phase of cerebral ischemia are improved,and the energy metabolism of cerebral ischemia is improved. Common agents are ozagrel injection, each 20mg.it is diluted by physiological saline or glucose injection then intravenous infusion, every day 80mg. when it is combined with other anti-platelet drugs, the dose of this product should be reduced. There may be bleeding tendency; occasional allergy, liver dysfunction, blood pressure drops, the outdoor contraction, headache, injection site pain, abdominal distension and other adverse reactions. Hemorrhage patients (intracerebral hemorrhage, intraventricular hemorrhage, gastrointestinal bleeding, subcutaneous bleeding, etc.), pregnant women or potentially pregnant women and children should use with caution. And it has a synergistic effect with drugs having inhibition of platelet function ,when they are used together, there must be appropriate reduction. Avoid mixing injection with calcium solution (Green solution, etc.) in order to avoid opacification.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical Properties

Obtain prismatic crystals From ethanol-diethyl ether , melting point 223~224 ℃.
Hydrochloric acid Ozagrel (Ozagrel Hydrochloride): C13H12N2O2 HCl. [78712-43-3]. crystallization From ethanol-ethyl ether , melting point 214~217 ℃.
Ozadrel Sodium: C13 H11N2NaO2. White crystal or crystalline powder, odorless, Pickle bitter. Soluble in water, soluble in methanol, insoluble in ethanol, acetone or ether. Acute toxicity LD50 male and female mice, male and female rats (mg/kg): 1940,1580,1150,1300 intravenous injection; 3800.3600.5900,5700 oral; 2450,2100,2300,2250 subcutaneous injection.

Uses

Strong thromboxane synthetase inhibitors. By inhibiting thromboxane synthase,it reduces the body thromboxane A, (TXA2), and promotes prostacyclin (PGl2) generation to be against aggregation of platelets, and cerebrovascular spasm, and it almost has no effect on cyclooxygenase and other arachidonic metabolizing enzymes.it is Clinically used for improving cerebral vasospasm after cobweb inferior vena hemorrhage surgery and symptoms of cerebral ischemia associated with cerebral vasospasm, and dyskinesia associated with cerebral thrombosis acute phase.

production method

Use dehydrated methyl benzaldehyde as materials,after condensation with acetic anhydride aldol ,form 3-tolyl acrylate, become into a 3--tolyl acrylate ethyl after esterification , use benzoyl peroxide as an initiator, with N-bromosuccinimide (NBS) ,make the methyl on the ring become into bromomethyl, and after the hydrolysis reaction with imidazole, ozagrel sodium is obtained , melting point 308 ℃ (decomposition).

Description

Ozagrel sodium is the first thromboxane (TX2) synthetase inhibitor to be developed as an antithrombotic agent. In patients with angina pectoris, ozagrel sodium reportedly decreases the frequency of anginal attacks and increases exercise tolerance. Other indications for ozagrel sodium currently under study include bronchial asthma and pulmonary thromboembolism.

Originator

Ono (Japan)

Uses

Ozagrel is a potent and selective thromboxane A2 inhibitor. Used in the prevention of ischemic stroke injury and maintains a strong effect in vascular contraction and vascular endothelial cell dysfunction.

Definition

ChEBI: Ozagrel is a member of cinnamic acids.

brand name

Xanbon; Cataclot

78712-43-3
82571-53-7
Synthesis of Ozagrel from Ozagrel hydrochloride

Ozagrel Preparation Products And Raw materials

Global( 312)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 566 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967 kaia@neputrading.com China 1011 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082 ericqiao@jnchsd.com CHINA 158 58
Jinan Jianfeng Chemical Co., Ltd
+8615562555968 info@pharmachemm.com China 246 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Wuhan Chemwonders Technology Inc.
027-85778276 info@chemwonders.com CHINA 176 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58

View Lastest Price from Ozagrel manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ozagrel pictures 2023-09-23 Ozagrel
82571-53-7
US $50.00 / kg 1kg 0.99 10000 Hebei Yanxi Chemical Co., Ltd.
Ozagrel pictures 2023-04-17 Ozagrel
82571-53-7
US $500.00 / KG 1KG 99% 500T Shanghai Yunao International Trade Co., Ltd
Ozagrel pictures 2022-04-26 Ozagrel
82571-53-7
US $100.00 / bag 1bag 99 500 Shanxi Naipu Import and Export Co.,Ltd
  • Ozagrel pictures
  • Ozagrel
    82571-53-7
  • US $50.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • Ozagrel pictures
  • Ozagrel
    82571-53-7
  • US $500.00 / KG
  • 99%
  • Shanghai Yunao International Trade Co., Ltd
  • Ozagrel pictures
  • Ozagrel
    82571-53-7
  • US $100.00 / bag
  • 99
  • Shanxi Naipu Import and Export Co.,Ltd

Ozagrel Spectrum

(E)-4-(1-Imidazoylmethyl)cinnamic acid 2-Propenoic acid, 3-[4-(1H-imidazol-1-ylmethyl)phenyl]-, (2E)- (E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]propenoic acid (E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]acrylic acid 3-[4-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2E-PROPENOIC ACID Ozagrel API Ozagrel(OKY-046) (2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid (E)-3-[P-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2-PROPENOIC ACID (e)-3-[4-(1h-imidiazol-1-ylmethyl)phenyl]-2-propenic acid OKY-046 OZAGREL (E)-4-(Imidazol-1-ylmethyl)cinnamic acid Cataclot Xanbon ozagrel ozagrel sodium OzagrelSodium99% OzagrelSodiumBase OzagrelC13H12N2O2 Ozagrel Hcl / Sodium Base Ozagrel HCl / Sodium Ozagrel (Sodium) Ozagrel HCl Ozagrel (base and/or unspecified salts) Ozagrel, ≥98% (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid (E)-3-(4-(2-(1H-imidazol-1-yl)-2-oxoethyl)phenyl)acrylic acid Mr Zardari gray Ozagrel USP/EP/BP Ozagre (2E)-3-{4-[(1H-imidazol-1-yl)methyl]phenyl}prop-2-enoic acid (E)-3-(4-((1H-Imidazol-1-yl)methyl)phenyl)acrylic acid 82571-53-7 C13H12N2O2 Cardiovascular Series Inhibitors Pharmaceutical material and intermeidates Cardiovascular 82571-53-7