Ferrostatin-1 (Fer-1)
- CAS No.
- 347174-05-4
- Chemical Name:
- Ferrostatin-1 (Fer-1)
- Synonyms
- Fer1;Fer 1;Fer-1;3-amino-4-(cycL;CCP.347174-05-4-G-1;Ferrostatin-1 (Fer-1);Ferrostatin-1 (Fer-1) USP/EP/BP;Ethyl 3-amino-4-(cyclohexylamino)benzoate;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
- CBNumber:
- CB32484317
- Molecular Formula:
- C15H22N2O2
- Molecular Weight:
- 262.35
- MDL Number:
- MFCD08072959
- MOL File:
- 347174-05-4.mol
- MSDS File:
- SDS
| Boiling point | 437.3±35.0 °C(Predicted) |
|---|---|
| Density | 1.150±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 4.78±0.11(Predicted) |
| form | powder |
| color | purple to brown |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
Ferrostatin-1 (Fer-1) price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0583 | Ferrostatin-1 ≥95% (HPLC) | 347174-05-4 | 5mg | $79.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0583 | Ferrostatin-1 ≥95% (HPLC) | 347174-05-4 | 25mg | $324 | 2024-03-01 | Buy |
| Cayman Chemical | 17729 | Ferrostatin-1 ≥90% | 347174-05-4 | 5mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 17729 | Ferrostatin-1 ≥90% | 347174-05-4 | 10mg | $94 | 2024-03-01 | Buy |
| Cayman Chemical | 17729 | Ferrostatin-1 ≥90% | 347174-05-4 | 25mg | $177 | 2024-03-01 | Buy |
Ferrostatin-1 (Fer-1) Chemical Properties,Uses,Production
Description
Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1?Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1?Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2?Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.
Uses
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis.
Definition
ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine.
Biochem/physiol Actions
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
storage
Store at +4°C
References
1) Dixon et al. (2012), Ferroptosis: an iron-dependent form of nonapoptotic cell death; Cell, 149 1060 2) Louandre et al. (2013), Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib; Int. J. Cancer, 133 1732 3) Skouta et al. (2014), Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models; J. Am. Chem. Soc., 136 4551 4) Nowak et al. (2013), Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells; Am. J. Physiol. Renal. Physiol., 305 F764
Ferrostatin-1 (Fer-1) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
View Lastest Price from Ferrostatin-1 (Fer-1) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | Ferrostatin-1 (Fer-1)
347174-05-4
|
US $0.00-0.00 / KG | 5mg | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-23 | Ferrostatin-1 (Fer-1)
347174-05-4
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- Ferrostatin-1 (Fer-1)
347174-05-4
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Ferrostatin-1 (Fer-1)
347174-05-4
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co