Ferrostatin-1 (Fer-1)
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- CAS号:
- 347174-05-4
- 英文名:
- Ferrostatin-1 (Fer-1)
- 英文别名:
- Fer1;Fer 1;Fer-1;3-amino-4-(cycL;CCP.347174-05-4-G-1;Ferrostatin-1 (Fer-1);Ferrostatin-1 (Fer-1) USP/EP/BP;Ethyl 3-amino-4-(cyclohexylamino)benzoate;3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
- 中文名:
- Ferrostatin-1 (Fer-1)
- 中文别名:
- 铁抑素-1;铁抑制剂-1;铁抑胃酶氨酰锡-1;3-氨基-4-环己基氨基苯甲酸乙酯;3-氨基-4-(环己胺O)苯甲酸乙酯;FERROSTATIN-1 (FER-1),雌激素诱导的肥大病抑制剂
- CBNumber:
- CB32484317
- 分子式:
- C15H22N2O2
- 分子量:
- 262.35
- MOL File:
- 347174-05-4.mol
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Ferrostatin-1 (Fer-1)化学性质
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沸点:
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437.3±35.0 °C(Predicted)
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密度:
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1.150±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系数(pKa):
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4.78±0.11(Predicted)
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形态:
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powder
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颜色:
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purple to brown
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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InChIKey:
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UJHBVMHOBZBWMX-UHFFFAOYSA-N
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Ferrostatin-1 (Fer-1)性质、用途与生产工艺
Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂,EC50为60 nM。
Ferrostatin-1(2 μM)作用于癌细胞,抑制Erastin诱导的Ferroptosis,Ferroptosis是一种铁依赖性的的非凋亡性细胞死亡,Ferrostatin-1作用于新生大鼠脑片,抑制 谷氨酸盐诱导的细胞死亡。Ferrostatin-1是一种脂质ROS清除剂,具有N-环己基部分,作为生物膜内亲脂锚。Ferrostatin-1不抑制细胞外信号调节激酶(ERK)磷酸化或HT-1080细胞增殖停滞,说明Ferrostatin-1不抑制MEK/ERK通路,螯合铁,或抑制蛋白合成。Ferrostatin-1抑制Erastin诱导的胞浆和脂质ROS积累。的无细胞条件下,Ferrostatin-1容易氧化稳定自由基2,2-二苯基-1-苦肼基(DPPH)。
Ferrostatin-1 (Fer-1)是一种有效的选择性的ferroptosis抑制剂,EC50为60 nM。
Target | Value |
Ferroptosis
(HT-1080 cells)
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60 nM(EC50)
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Ferrostatin-1(2 μM)作用于癌细胞,抑制Erastin诱导的Ferroptosis,Ferroptosis是一种铁依赖性的的非凋亡性细胞死亡,Ferrostatin-1作用于新生大鼠脑片,抑制 谷氨酸盐诱导的细胞死亡。Ferrostatin-1是一种脂质ROS清除剂,具有N-环己基部分,作为生物膜内亲脂锚。Ferrostatin-1不抑制细胞外信号调节激酶(ERK)磷酸化或HT-1080细胞增殖停滞,说明Ferrostatin-1不抑制MEK/ERK通路,螯合铁,或抑制蛋白合成。Ferrostatin-1抑制Erastin诱导的胞浆和脂质ROS积累。的无细胞条件下,Ferrostatin-1容易氧化稳定自由基2,2-二苯基-1-苦肼基(DPPH)。
Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction .
Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviated LPS-induced induced acute lung injury (ALI).
Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis.
Animal Model:
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Male C57BL/6 mice (LPS-induced ALI)
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Dosage:
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0.8 mg/kg
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Administration:
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Tail vein injection
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Result:
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Exerted therapeutic action against LPS-induced ALI.
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Ferrostatin-1 (Fer-1)
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2021/03/30 | S7243 | Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) | 347174-05-4 | 5mg | 1193.05元 |
2021/03/30 | S7243 | Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) | 347174-05-4 | 10mM(1mL in DMSO) | 3252.11元 |
Ferrostatin-1 (Fer-1)
生产厂家
347174-05-4, Ferrostatin-1 (Fer-1) 相关搜索:
- Inhibitors
- 抑制剂
- 药靶配体
- 化合物
- 代谢
- 小分子抑制剂,天然产物
- FERROSTATIN-1 (FER-1),雌激素诱导的肥大病抑制剂
- 铁抑胃酶氨酰锡-1
- 铁抑素-1
- 铁抑制剂-1
- 3-氨基-4-(环己胺O)苯甲酸乙酯
- 3-氨基-4-环己基氨基苯甲酸乙酯
- 347174-05-4
- CCP.347174-05-4-G-1
- Ferrostatin-1 (Fer-1) USP/EP/BP
- 3-amino-4-(cycL
- (Ferrostatin-1 (Fer-1))3-Amino-4-cyclohexylamino benzoic acid ethyl ester
- FER-1;FER 1;FER1;FERROSTATIN-1;FERROSTATIN 1;FERROSTATIN1
- Fer-1
- Fer1
- Fer 1
- Ferrostatin-1 (Fer-1)
- 3-Amino-4-cyclohexylaminobenzoic acid ethyl ester
- Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
- Ethyl 3-amino-4-(cyclohexylamino)benzoate