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2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine structure

CAS No.: 934524-10-4

Chemical Name:: 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

Synonyms: ,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine;2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine;2,4-Dichloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyriMidine;2,4-dichloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine;2,4-dichloro-7-(4-methylbenzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine;2,4-Dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-7-[(4-Methylphenyl)sulfonyl]-;2,4-Dichloro-7-p-Methylbenzenesulfonyl-7H-Pyrrole[2,3-d]Pyrimidin-4-Amine

CBNumber:: CB32550243

Molecular Formula:: C13H9Cl2N3O2S

Molecular Weight:: 342.2

MDL Number:: MFCD13193624

MOL File:: 934524-10-4.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	B419308	50mg	$45
2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	B419308	100mg	$60
2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	FD144057	250mg	$77.5
2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 95+%	073810	250mg	$231
2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	FD144057	1g	$237
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2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Properties

Melting point	163-164°
Boiling point	447.1±55.0 °C(Predicted)
Density	1.59
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	0.47±0.30(Predicted)
Appearance	Off-white to light yellow Solid
FDA UNII	44TZH2Y76U

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B419308	2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	934524-10-4	50mg	$45	2021-12-16	Buy
TRC	B419308	2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	934524-10-4	100mg	$60	2021-12-16	Buy
Biosynth Carbosynth	FD144057	2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	934524-10-4	250mg	$77.5	2021-12-16	Buy
Matrix Scientific	073810	2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 95+%	934524-10-4	250mg	$231	2021-12-16	Buy
Biosynth Carbosynth	FD144057	2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine	934524-10-4	1g	$237	2021-12-16	Buy

Product number	Packaging	Price	Buy
B419308	50mg	$45	Buy
B419308	100mg	$60	Buy
FD144057	250mg	$77.5	Buy
073810	250mg	$231	Buy
FD144057	1g	$237	Buy

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Chemical Properties,Uses,Production

Synthesis

90213-66-4

98-59-9

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine

934524-10-4

Using 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (1.00 g, 5.32 mmol) and p-toluenesulfonyl chloride (1.115 g, 5.85 mmol) as the raw materials, the two were dissolved in dichloromethane (20 mL) along with tetrabutylammonium hydrogen sulfate (0.090 g, 0.27 mmol) at room temperature. Subsequently, 50% aqueous sodium hydroxide solution (1 mL) was added to the reaction mixture and stirred at room temperature for 30 min. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was diluted with deionized water and dichloromethane and the organic layer was separated. The organic layer was concentrated by vacuum evaporation to give a light yellow solid. The crude product was purified by column chromatography (100% dichloromethane as eluent) to afford the target product 2,4-dichloro-7-toluenesulfonyl-7H-pyrrolo[2,3-d]pyrimidine (1.76 g, 97% yield) as a white solid. The mass spectrum (LCMS) showed [M + H]+ m/z 342. 1H NMR (400 MHz, chloroform-d) δ ppm: 8.14 (d, J = 8.59 Hz, 2H), 7.78 (d, J = 3.79 Hz, 1H), 7.39 (d, J = 8.59 Hz, 2H), 6.70 (d, J = 3.79 Hz, 1H). 2.45 (s, 3H).

References

[1] Patent: WO2010/38060, 2010, A1. Location in patent: Page/Page column 68-69
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 1, p. 144 - 158
[3] Patent: WO2010/123919, 2010, A2. Location in patent: Page/Page column 55
[4] Patent: WO2017/106771, 2017, A1. Location in patent: Paragraph 00397
[5] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 400

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Preparation Products And Raw materials

Raw materials

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE p-Toluenesulfonic acid Tosyl chloride Sodium hydroxide Water

Dichloromethane

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Preparation Products

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	tinayang@enbridgepharm.com	China	306	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Hunan Jibang Biological Technology Co., LTD	+8613776644403	sales02@kingboomtech.com	China	1804	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
ENBRIDGE PHARMTECH CO., LTD.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Labnetwork lnc.	58
Hunan Jibang Biological Technology Co., LTD	58

View Lastest Price from 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine 934524-10-4	US $2.00 / KG	1g	98%min	ask	Career Henan Chemical Co

,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine
934524-10-4
US $2.00 / KG
98%min
Career Henan Chemical Co

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine Spectrum

2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine(934524-10-4)¹HNMR

934524-10-4(2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine)Related Search:

2,4-DIFLUOROPYRIMIDINE 3-(BOC-AMINO)-4-PICOLINE 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid tert-butyl methyl((3R,4R)-4-methyl-1-tosylpiperidin-3-yl)carbamate N-((3SR,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

(3RS,4SR)-methyl 1-benzyl-4-methylpiperidin-3-ylcarbamate ((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-Methyl-piperidin-3-ol 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE (3SR,4SR)-1-benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 3-((3RS,4RS)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid ((3SR,4RS-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2-Chloro-3,7-dihydro-4H-pyrrolo[2,3-d]pyriMidin-4-one Tofacitinib

(3R,4R)-N,4-dimethyl-1-tosylpiperidin-3-amine N-((3RS,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3RS,4SR)-1-benzyl-N-methyl-4-methylpiperidin-3-amine bis-(hydrochloride)

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2,4-Dichloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyriMidine 7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-7-[(4-Methylphenyl)sulfonyl]- 2,4-Dichloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine 2,4-Dichloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine ,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine 2,4-dichloro-7-(4-methylbenzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 2,4-dichloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine 2,4-Dichloro-7-p-Methylbenzenesulfonyl-7H-Pyrrole[2,3-d]Pyrimidin-4-Amine 934524-10-4 Heterocycle-Pyrimidine series