(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- CAS No.
- 173897-44-4
- Chemical Name:
- (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- Synonyms
- Y-33075 HCl;Y 39983 2HCL;Y-33075 2HCl;Y 39983, 2 HCl salt;Y39983 HYDROCHLORIDE;Y39983 dihydrochlortide;Y-33075 (dihydrochloride);(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride;Y33075 dihydrochloride,ROCK,Y33075,Y 33075,ROK,Rho-associated kinase,Inhibitor,Rho-associated protein kinase,Y 33075 dihydrochloride,Rho-kinase,inhibit,Y-33075
- CBNumber:
- CB32554140
- Molecular Formula:
- C16H18Cl2N4O
- Molecular Weight:
- 353.24632
- MDL Number:
- MFCD00945328
- MOL File:
- 173897-44-4.mol
- MSDS File:
- SDS
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A594890 | Y-39983Hydrochloride | 173897-44-4 | 2.5mg | $220 | 2021-12-16 | Buy |
ChemScene | CS-0096 | Y-33075dihydrochloride 97.34% | 173897-44-4 | 10mg | $240 | 2021-12-16 | Buy |
ApexBio Technology | B1176 | Y-39983dihydrochloride | 173897-44-4 | 10mg | $315 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | KIN0002446 | (R)-4-(1-AMINOETHYL)-N-(1H-PYRROLO[2,3-B]PYRIDIN-4-YL)BENZAMIDE DIHYDROCHLORIDE 95.00% | 173897-44-4 | 5MG | $497.43 | 2021-12-16 | Buy |
ChemScene | CS-0096 | Y-33075dihydrochloride 97.34% | 173897-44-4 | 5mg | $144 | 2021-12-16 | Buy |
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Chemical Properties,Uses,Production
Uses
Y-39983 Hydrochloride contain Rho kinase inhibitory activity.
Biological Activity
y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].
References
[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.
[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6009 | 61 |
Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9900 | 58 | |
Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4576 | 55 |