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ChemicalBook >> CAS DataBase List >>(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Structure
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide structure
CAS No.
199433-58-4
Chemical Name:
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
Synonyms
Y 33075;Y 33075,Y33075;Y 39983;Y39983;Y33075;Y 39983;(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide;4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide;Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-;(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH
CBNumber:
CB62510121
Molecular Formula:
C16H16N4O
Molecular Weight:
280.32
MDL Number:
MFCD16038858
MOL File:
199433-58-4.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Properties

Boiling point 588.8±50.0 °C(Predicted)
Density 1.32
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (178.37 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka 11.13±0.20(Predicted)
FDA UNII 00ALI1GAY2

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0097 Y-33075 99.19% 199433-58-4 10mg $330 2021-12-16 Buy
American Custom Chemicals Corporation API0014195 Y-33075 95.00% 199433-58-4 10MG $517.65 2021-12-16 Buy
ChemScene CS-0097 Y-33075 99.19% 199433-58-4 50mg $1188 2021-12-16 Buy
Crysdot CD31002772 Y-33075 98+% 199433-58-4 50mg $644 2021-12-16 Buy
CSNpharm CSN18082 Y-33075 199433-58-4 25mg $500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0097 10mg $330 Buy
API0014195 10MG $517.65 Buy
CS-0097 50mg $1188 Buy
CD31002772 50mg $644 Buy
CSN18082 25mg $500 Buy

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Chemical Properties,Uses,Production

Definition

ChEBI: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide is a pyrrolopyridine.

Biological Activity

Y-33075 is a potent ROCK inhibitor derived from Y-27632, but more active with IC50 value of 3.6 nM.

in vitro

Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC 50 of 3.6 nM. It also inhibits PKC and CaMKII more potently than Y-27632, and the IC 50 s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC 50 s of Y-27632 and Y- 33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC 50 s of Y-27632 and Y-33075 for PKC are 82 and 117 times those for ROCK, respectively, whereas the IC 50 s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. It (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca 2+ -free solutions. Y-33075 ( 10 μM) shows no effect on the [Ca 2+ ]i increase with the high-potassium (high-K) solution.

p>

target

ROCK

3.6 nM (IC 50 )

PKC

420 nM (IC 50 )

CaMKII

810 nM (IC 50 )

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9320 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6011 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Codow Chemical Co.,Ltd. 18620099427 amy@howeipharm.com China 17698 55
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
LETOPHARM LIMITED 58
Codow Chemical Co.,Ltd. 55

View Lastest Price from (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide pictures 2024-04-17 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
199433-58-4
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide pictures 2021-10-14 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide
199433-58-4
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

199433-58-4((R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide)Related Search:

PRND N-Ethylaniline Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Y-27632 DIHYDROCHLORIDE

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(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Y 33075 Y33075;Y 39983 Y 39983;Y39983 Benzamide, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl- 4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide ISO 9001：2015 REACH Y 33075,Y33075 199433-58-4