N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
- CAS No.
- 932986-18-0
- Chemical Name:
- N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
- Synonyms
- CS-1554;Azoramide;Azoraminde;N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide;N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide;Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-;N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
- CBNumber:
- CB32641660
- Molecular Formula:
- C15H17ClN2OS
- Molecular Weight:
- 308.83
- MDL Number:
- MFCD08009374
- MOL File:
- 932986-18-0.mol
- MSDS File:
- SDS
| Melting point | 90-93°C |
|---|---|
| Density | 1.215 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml) |
| form | solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18045 | Azoramide ≥98% | 932986-18-0 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18045 | Azoramide ≥98% | 932986-18-0 | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 18045 | Azoramide ≥98% | 932986-18-0 | 25mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18045 | Azoramide ≥98% | 932986-18-0 | 50mg | $341 | 2024-03-01 | Buy |
| TRC | A965090 | Azoramide | 932986-18-0 | 25mg | $75 | 2021-12-16 | Buy |
N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Chemical Properties,Uses,Production
Description
The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 μM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element. At 1-25 μM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis. At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.
Uses
Azoramide improves endoplasmic reticulum (ER) protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. It also showed antidiabetic activity by improving insulin sensitivity and pancreatic β cell function.
References
1) Fu?(2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med., 7?292ra98
N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
View Lastest Price from N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
932986-18-0
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
932986-18-0
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co