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Pharmacological effects Chemical properties Uses Production methods Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Nifedipine structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Nifedipine Properties

Melting point:
171-175 °C
Boiling point:
481.08°C (rough estimate)
1.2109 (rough estimate)
refractive index 
1.5486 (estimate)
storage temp. 
DMSO: soluble
pKa -0.9/>13(DMF,t undefined) (Uncertain)
Water Solubility 
<0.1 g/100 mL at 19.5 ºC
CAS DataBase Reference
21829-25-4(CAS DataBase Reference)
EWG's Food Scores
Proposition 65 List
ATC code
NIST Chemistry Reference
EPA Substance Registry System
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330-P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  US7975000
HazardClass  IRRITANT
HS Code  29333990
Toxicity LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)

Nifedipine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 481981 Nifedipine Relatively selective blocker of L-type Ca 21829-25-4 250mg $64.19 2021-03-22 Buy
Sigma-Aldrich 1463508 Nifedipine United States Pharmacopeia (USP) Reference Standard 21829-25-4 125mg $297 2021-03-22 Buy
Sigma-Aldrich N0750000 Nifedipine European Pharmacopoeia (EP) Reference Standard 21829-25-4 $190 2021-03-22 Buy
TCI Chemical N0528 Nifedipine >98.0%(HPLC)(E) 21829-25-4 10g $70 2021-03-22 Buy
TCI Chemical N0528 Nifedipine >98.0%(HPLC)(E) 21829-25-4 25g $130 2021-03-22 Buy

Nifedipine Chemical Properties,Uses,Production

Pharmacological effects

Nifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the Ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. Small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
Nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
The above information is edited by the chemicalbook of Tian Ye.

Chemical properties

Yellow crystals. Melting point 172-174 ℃. Soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. It easily deteriorates in case of light.


Long-term coronary vasodilators. This product can increase coronary blood flow, reducing myocardial oxygen is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.

Production methods

O-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . The crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.


Toxic substances

Toxicity grading

Highly toxic

Acute toxicity

Oral-rat LD50: 1022 mg/kg; Oral-Mouse LD50: 310 mg/kg.

Flammability and hazard characteristics

Combustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.

Storage Characteristics

Ventilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, water spray.

Chemical Properties

Yellow Crystalline Solid


Adalat,Bayer,W. Germany,1975


Used as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker


Nifedipine is used for preventing and relieving angina pectoris attacks, for hypertension, and as an ingredient in combination therapy for chronic cardiac insufficiency.


For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Manufacturing Process

45 grams 2-nitrobenzaldehyde, 80 cc acetoacetic acid methyl ester, 75 cc methanol and 32 cc ammonia are heated under reflux for several hours, filtered off, cooled and, after suction-filtration, 75 grams of yellow crystals of MP 172° to 174°C are obtained, according to US Patent 3,485,847.

brand name

Adalat (Bayer); Afeditab (Watson);Procardia (Pfizer).

Therapeutic Function

Coronary vasodilator

World Health Organization (WHO)

Nifedipine is a dihydropyridine calcium channel blocker. It is listed in the WHO Model List of Essential Drugs. The 10mg tablet is retained on the list for short-term treatment of hypertension. Sustained-release preparations are advised for long-term treatment.

General Description

Nifedipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate dimethyl ester(Adalat, Procardia), is a dihydropyridine derivative thatbears no structural resemblance to the other calcium antagonists.It is not a nitrate, but its nitro group is essential for itsantianginal effect. As a class, the dihydropyridines possessa central pyridine ring that is partially saturated. To this, positions2 and 6 are substituted with an alkyl group that mayplay a role in the agent’s duration of action. In addition, positions3 and 5 are carboxylic groups that must be protectedwith an ester functional group. Depending on the type ofester used at these sites, the agent can be distributed to variousparts of the body. Finally, position 4 requires an aromaticsubstitution possessing an electron-withdrawinggroup (i.e., Cl or NO2) in the ortho and/or meta position.

General Description

Odorless yellow crystals or powder. Tasteless.

Air & Water Reactions

Aqueous solutions are very sensitive to light. . Insoluble in water.

Reactivity Profile

Nifedipine is sensitive to light.

Fire Hazard

Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible.

Biological Activity

L-type calcium channel blocker.

Mechanism of action

Nifedipin causes relaxation of smooth musculature, dilation of coronary and peripheral arteries, and reduction of peripheral resistance and arterial blood pressure, and enhances oxygen supply to the heart.

Clinical Use

The prototype of this class, nifedipine, has potent peripheralvasodilatory properties. It inhibits the voltage-dependentcalcium channel in the vascular smooth muscle but has littleor no direct depressant effect on the SA or AV nodes, eventhough it inhibits calcium current in normal and isolated cardiactissues. Nifedipine is more effective in patients whoseanginal episodes are caused by coronary vasospasm and isused in the treatment of vasospastic angina as well as classicangina pectoris. Because of its strong vasodilatory properties,it is used in selected patients to treat hypertension.

Chemical Synthesis

Nifedipine, dimethyl ether 1,4-dihydro-2,6-dimethyl-4-(2′-nitrophenyl)-3,5- piridindicarboxylic acid (19.3.16), is synthesized by a Hantsch synthesis from two molecules of a β-dicarbonyl compound—methyl acetoacetate, using as the aldehyde component— 2-nitrobenzaldehyde and ammonia. The sequence of the intermediate stages of synthesis has not been completely established.

Nifedipine Preparation Products And Raw materials

Raw materials

Preparation Products

Nifedipine Suppliers

Global( 488)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Univar Solutions(China) Co., Ltd.
86-21-61932700 CHINA 275 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8909 55
Guangzhou PI PI Biotech Inc
020-81716319; China 3245 55
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
career henan chemical co
+86-371-86658258 CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338 CHINA 2007 58
Accela ChemBio Inc.
(+1)-858-876-1948 United States 19969 58

View Lastest Price from Nifedipine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Nifedipine
2021-11-02 Nifedipine
US $142.90-2777.80 / KG 1KG 99% 2000kg Baoji Guokang Healthchem co.,ltd
2021-10-29 Nifedipine
US $0.00 / ASSAYS 100ASSAYS 99.99 10000 Jiangsu Monade Biological Technology Co., Ltd.

Nifedipine Spectrum

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