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Pharmacological effects Chemical properties Uses Production methods Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Nifedipine Properties

Melting point:
171-175 °C
Boiling point:
481.08°C (rough estimate)
1.2109 (rough estimate)
refractive index 
1.5486 (estimate)
storage temp. 
DMSO: soluble
pKa -0.9/>13(DMF,t undefined) (Uncertain)
Water Solubility 
<0.1 g/100 mL at 19.5 ºC
CAS DataBase Reference
21829-25-4(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-( 2-nitrophenyl)-, dimethyl ester(21829-25-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  US7975000
HazardClass  IRRITANT
HS Code  29333990
Toxicity LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Nifedipine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 481981 Nifedipine Relatively selective blocker of L-type Ca 21829-25-4 250mg $64.4 2018-11-20 Buy
Sigma-Aldrich 1463508 Nifedipine United States Pharmacopeia (USP) Reference Standard 21829-25-4 125mg $286.65 2018-11-13 Buy
TCI Chemical N0528 Nifedipine >98.0%(HPLC)(E) 21829-25-4 10g $69 2018-11-22 Buy
TCI Chemical N0528 Nifedipine >98.0%(HPLC)(E) 21829-25-4 25g $128 2018-11-22 Buy
Alfa Aesar J62811 Nifedipine, 98% 21829-25-4 25g $199 2018-11-13 Buy

Nifedipine Chemical Properties,Uses,Production

Pharmacological effects

Nifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the Ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. Small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
Nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
The above information is edited by the chemicalbook of Tian Ye.

Chemical properties

Yellow crystals. Melting point 172-174 ℃. Soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. It easily deteriorates in case of light.


Long-term coronary vasodilators. This product can increase coronary blood flow, reducing myocardial oxygen is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.

Production methods

O-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . The crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.


Toxic substances

Toxicity grading

Highly toxic

Acute toxicity

Oral-rat LD50: 1022 mg/kg; Oral-Mouse LD50: 310 mg/kg.

Flammability and hazard characteristics

Combustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.

Storage Characteristics

Ventilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, water spray.

Chemical Properties

Yellow Crystalline Solid


For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).


Used as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker

brand name

Adalat (Bayer); Afeditab (Watson);Procardia (Pfizer).

General Description

Odorless yellow crystals or powder. Tasteless.

Air & Water Reactions

Aqueous solutions are very sensitive to light. . Insoluble in water.

Reactivity Profile

Nifedipine is sensitive to light.

Fire Hazard

Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible.

Biological Activity

L-type calcium channel blocker.

Nifedipine Preparation Products And Raw materials

Raw materials

Preparation Products

Nifedipine Suppliers

Global( 337)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
020-81716319 CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 552 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1659 55
13606120588 CHINA 8430 58
Hubei Jusheng Technology Co.,Ltd.
86-155-27864001 CHINA 18004 58

View Lastest Price from Nifedipine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-03-15 Nifedipine powder 21829-25-4
US $10.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-12-18 Nifedipine
US $7.00 / kg 1kg 99% 100KG career henan chemical co

Nifedipine Spectrum

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